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Genomic Aberrations in Human Hepatoblastomas Detected by 2-Dimensional Gel Analysis¹

Institute for Molecular and Cellular Biology, Osaka University, 1-3, Yamada-oka, Suita, Osaka 565, Japan [H. N., M. P., Y-S. K., K. M.]; First Department of Surgery, Hiroshima University Medical School, 1-2-3, Kasumi-cho, Hiroshima 720, Japan [H. T.]; Department of Biochemistry, Faculty of Science, Mahidol University, Rama VI road, Bangkok 10400, Thailand [M. P.]; and Department of Molecular Biology, Genetic Engineering Research Institute, KIST, P.O. Box 115, Yusong, Taejon, 305-600, Korea [Y-S. K.]

Hepatoblastoma is a frequent embryonic tumor found in children. The mechanism of its formation and development remain unknown. We analyzed genomic DNA aberrations associated with three hepatoblastomas by means of restriction landmark genomic scanning (I. Hatada et al., Proc. Natl. Acad. Sci. USA, 88:9523–9527, 1991). About 2000 NotI restriction landmarks were monitored in each of the hepatoblastomas, which revealed that the intensity of eight spots decreased in the tumor genome, suggesting allelic loss. Three of these spots were identical to those that decreased in human hepatocellular carcinomas. These results suggested that common, early events are involved in the genesis of the two types of liver tumor.

¹ This work was supported in part by a Grant-in-Aid for Creative Basic Research (Human Genome Program) from the Ministry of Education, Science and Culture, Japan.

² To whom requests for reprints should be addressed.

Received 8/ 2/95. Accepted 8/29/95.

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