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[Cancer Research 55, 4752-4756, November 1, 1995]
© 1995 American Association for Cancer Research
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Treatment of Human Malignant Meningiomas by G207, a Replication-competent Multimutated Herpes Simplex Virus 11

Takahito Yazaki2, Herbert J. Manz, Samuel D. Rabkin and Robert L. Martuza3

Georgetown Brain Tumor Center, Departments of Neurosurgery [T. Y., S. D. R., R. L. M.], Microbiology and Immunology [S. D. R.], and Pathology [H. J. M.], Georgetown University Medical Center, Washington, DC 20007

We have demonstrated that replication-competent attenuated mutants of herpes simplex virus type 1 (HSV-1) have therapeutic potential for malignant gliomas. Moreover, a recently described multiple mutant HSV (termed G207) has properties which may allow human clinical trials. G207 is able to replicate within and kill cells from three human malignant meningiomas in cell culture. In nude mice harboring s.c. human malignant meningioma (F5), G207 can inhibit growth in a dose-dependent fashion. In nude mice harboring intracranial subdural human malignant meningioma (F5), one injection of G207 caused significantly decreased tumor growth and one apparent cure with neither neurological dysfunction nor pathological changes in the surrounding brain. These results suggest that G207 should be considered for therapeutic trials in the treatment of malignant meningioma refractory to currently available therapies.

1 This study was supported in part by NIH Grants CA60176 and NS32677.

2 Present Address: Departments of Neurosurgery and Physiology, School of Medicine, Keio University, Shinjuku-ku, Tokyo 160, Japan.

3 To whom requests for reprints should be addressed, at Department of Neurosurgery, Georgetown University Medical Center, 3800 Reservoir Road, NW, Washington, DC 2007.

Received 8/ 7/95. Accepted 9/21/95.




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HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 1995 by the American Association for Cancer Research.