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Mismatch Repair, Somatic Mutations, and the Origins of Cancer

School of Microbiology, La Trobe University, Bundoora Campus, Melbourne, Victoria, Australia 3083

This paper outlines the basic properties of a newly recognized pathway that should enable somatic cells to generate double-stranded mutations in the complete absence of cell proliferation. Recognition of the existence of this pathway provides us with the basis for a better understanding of a number of important biological phenomena and, in particular, may help us to understand the origins of cancers in unselected human populations.

¹ To whom requests for reprints should be addressed. Phone: 61-3-9479-2768; Fax: 61-3-9479-1222.

Received 6/ 8/95. Accepted 9/26/95.

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