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International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon, Cedex 08, France [O. T., H. N., K. W., P. K., H. O.], and Institute of Neuropathology, University Hospital, 8091 Zürich, Switzerland [J. L., P. K.]
Fas/APO-1 (CD95) is an apoptosis-signaling receptor molecule on the surface of cells. To investigate the possible role of Fas during malignant transformation of glial cells, we analyzed the expression of Fas mRNA by reverse transcription-PCR in human astrocytic brain tumors. Expression was found in 1 of 4 (25%) juvenile pilocytic astrocytomas (WHO grade I), 1 of 9 (11%) low-grade astrocytomas (WHO grade II), 6 of 12 (50%) anaplastic astrocytomas (WHO grade III), and all of 9 glioblastomas (WHO grade IV). Thus, the frequency of Fas expression appears to correlate with the malignancy grade of astrocytomas. The soluble form of the Fas mRNA lacking the transmembrane domain was detected in one anaplastic astrocytoma and in two glioblastomas.
1 To whom requests for reprints should be addressed, at Unit of Molecular Pathology, IARC, 150 cours Albert Thomas, 69372 Lyon, Cedex 08, France. Phone: 33 72 73 85 34; Fax: 33 72 73 85 64.
Received 9/ 5/95. Accepted 10/19/95.
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