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Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037 [J. L., H. W. C., P. K. V.]; Memorial Sloan-Kettering Cancer Center, New York, New York 10021 [E. L.]; and Department of Cell and Molecular Biology, University of St. Andrews, St. Andrews, United Kingdom [E. J. P.]
The retroviral oncogene qin codes for a protein that belongs to the winged helix family of transcriptional regulators. The Qin protein is localized in the nucleus and binds to the same DNA consensus sequence as rat brain factor 1 (BF-1). Cellular Qin shows greater affinity to DNA than does viral Qin. Alone or fused to the DNA-binding domain of the yeast GAL4 protein, both Qin proteins act as transcriptional repressors. The major transcriptional repression domain maps to the region of amino acids 252–395 of viral Qin.
1 This work was supported by USPHS Service Grant CA 42564. J. L. is a recipient of the Council for Tobacco Research USA, Inc., Grant 4053. H. W. C. holds a fellowship of the Damon Runyon-Walter Winchell Foundation.
2 To whom requests for reprints should be addressed, at Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10666 North Torrey Pines Road, La Jolla, CA 92037. Phone: (619) 554-9745; Fax: (619) 554-6919.
Received 10/ 3/95. Accepted 10/18/95.
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