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Prelabeling of Chimeric Monoclonal Antibody L6 with ⁹⁰Yttrium- and ¹¹¹Indium-1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid (DOTA) Chelates for Radioimmunodiagnosis and Therapy¹

Department of Chemistry, University of California, Davis, California 95616 [M. L., C. F. M.], and Department of Internal Medicine, University of California Davis Medical Center, Sacramento, California 95817 [Q. S., D. L. K., G-R. Z., L. M., S. J. D.]

⁹⁰Y and ¹¹¹In have been attached to chimeric monoclonal antibody L6 with a bifunctional chelating agent (DOTA-peptide isothiocyanate). The bifunctional chelating agent was prelabeled with either radiometal and then conjugated to the antibody. Studies in human patients showed excellent ¹¹¹In single-photon emission computed tomography images of breast cancer lesions 24 h after injection.