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Laboratory and Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology [M. G. M., S. C-H. M., C. A. B., P. M. F., S-W. T., C. C. L., H. M. G., R. C. K., R. S. B.], and Division of Women's and Perinatal Pathology [W. R. W.], Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115
Histopathological evidence suggests that papillary serous carcinoma of the peritoneum (PSCP) may be multifocal in origin. Utilizing a PCR based method to detect tandem repeat polymorphisms in formalin fixed tissue, loss of heterozygosity at eight loci on chromosomes 1, 3, 4, and 17 was studied in six cases of PSCP. Loss of heterozygosity was assessed at between 5 and 11 tumor sites/patient. Allelic losses at 4 loci (1q32-qter, 3p14.3-21.1, 17q12, 17q21.3-23) were noted. Three cases demonstrated a different pattern of allelic loss at various anatomic sites within the same patient. In an additional case, a mutation of the p53 gene, detected by quantitative PCR followed by single-strand conformation polymorphism analysis, was detected in only 2 of 5 tumor sites. The pattern of allelic loss and the mutational pattern of the p53 gene varied at tumor sites within the same patient in 4 of 6 cases of PSCP. These findings are consistent with histopathological evidence that PSCP is multifocal in origin.
1 Supported in part by a grant from the American Cancer Society and by the William Graves Ovarian Cancer Research Fund, Boston, MA.
2 To whom requests for reprints should be addressed, at Seeley G. Mudd Building, 250 Longwood Avenue, Room 210, Boston, MA 02115.
Received 10/ 7/94. Accepted 12/16/94.
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