This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Chiou, H.-Y. Articles by Chen, C.-J. Search for Related Content PubMed PubMed Citation Articles by Chiou, H.-Y. Articles by Chen, C.-J.

Incidence of Internal Cancers and Ingested Inorganic Arsenic: A Seven-Year Follow-up Study in Taiwan¹

Institute of Epidemiology, College of Public Health, National Taiwan University, Jen-Ai Road Section 1, Taipei 10018 [H-Y. C., Y-M. H., K-F. L., S-F. L., M-H. C., C-J. C.]; School of Public Health, Taipei Medical College, Taipei 110 [H-Y. C., Y-M. H.]; Department of Oncology, National Taiwan University Hospital, Taipei 100 [Y-S. P.]; Department of Urology, National Cheng-Kung University, Tainan 704 [J. S-N. L.]; Department of Urology, Kaohsiung Medical College, Kaohsiung 807 [C-H.H.]; and Institute of Biomedical Sciences, Academia Sinica, Taipei 115 [C-J. C.], Taiwan

In order to elucidate the dose-response relationship between ingested inorganic arsenic and internal cancers, a total of 263 patients with blackfoot disease and 2293 healthy residents in the endemic area of arseniasis were recruited and followed up for 7 years. The information on consumption of high-arsenic artesian well water, sociodemographic characteristics, life-style and dietary habits, and personal and family history of cancers was obtained through standardized interviews. The occurrence of internal cancers among study subjects was determined through annual health examinations, home visit personal interviews, household registration data checks, and national death certification and cancer registry profile linkages. A dose-response relationship was observed between the long-term arsenic exposure from drinking artesian well water and the incidence of lung cancer, bladder cancer, and cancers of all sites combined after adjustment for age, sex, and cigarette smoking through Cox's proportional hazards regression analysis. Blackfoot disease patients had a significantly increased cancer incidence after adjustment for cumulative arsenic exposure.

¹ This study was supported by National Science Council, Republic of China Grants 80-0412-B002-17, 81-0412-B002-122, 82-0412-B002-262, and 83-0412-B002-231.

² To whom requests for reprints should be addressed.

Received 5/20/94. Accepted 1/17/95.

This article has been cited by other articles:

				S. Ying, K. Myers, S. Bottomley, T. Helleday, and H. E. Bryant BRCA2-dependent homologous recombination is required for repair of Arsenite-induced replication lesions in mammalian cells Nucleic Acids Res., August 1, 2009; 37(15): 5105 - 5113. [Abstract] [Full Text] [PDF]

				L. C. Platanias Biological Responses to Arsenic Compounds J. Biol. Chem., July 10, 2009; 284(28): 18583 - 18587. [Abstract] [Full Text] [PDF]

				E. Dopp, U. von Recklinghausen, L. M. Hartmann, I. Stueckradt, I. Pollok, S. Rabieh, L. Hao, A. Nussler, C. Katier, A. V. Hirner, et al. Subcellular Distribution of Inorganic and Methylated Arsenic Compounds in Human Urothelial Cells and Human Hepatocytes Drug Metab. Dispos., May 1, 2008; 36(5): 971 - 979. [Abstract] [Full Text] [PDF]

				L. R. Klei and A. Barchowsky Positive Signaling Interactions between Arsenic and Ethanol for Angiogenic Gene Induction in Human Microvascular Endothelial Cells Toxicol. Sci., April 1, 2008; 102(2): 319 - 327. [Abstract] [Full Text] [PDF]

				M. Sandoval, M. Morales, R. Tapia, L. del Carmen Alarcon, M. Sordo, P. Ostrosky-Wegman, A. Ortega, and E. Lopez-Bayghen p53 Response to Arsenic Exposure in Epithelial Cells: Protein Kinase B/Akt Involvement Toxicol. Sci., September 1, 2007; 99(1): 126 - 140. [Abstract] [Full Text] [PDF]

				G. Marshall, C. Ferreccio, Y. Yuan, M. N. Bates, C. Steinmaus, S. Selvin, J. Liaw, and A. H. Smith Fifty-Year Study of Lung and Bladder Cancer Mortality in Chile Related to Arsenic in Drinking Water J Natl Cancer Inst, June 20, 2007; 99(12): 920 - 928. [Abstract] [Full Text] [PDF]

				S. Somji, X. D. Zhou, S. H. Garrett, M. A. Sens, and D. A. Sens Urothelial Cells Malignantly Transformed by Exposure to Cadmium (Cd+2) and Arsenite (As+3) Have Increased Resistance to Cd+2 and As+3-Induced Cell Death Toxicol. Sci., December 1, 2006; 94(2): 293 - 301. [Abstract] [Full Text] [PDF]

				J. Ding, J. Li, C. Xue, K. Wu, W. Ouyang, D. Zhang, Y. Yan, and C. Huang Cyclooxygenase-2 Induction by Arsenite Is through a Nuclear Factor of Activated T-cell-dependent Pathway and Plays an Antiapoptotic Role in Beas-2B Cells J. Biol. Chem., August 25, 2006; 281(34): 24405 - 24413. [Abstract] [Full Text] [PDF]

				J.-I Chao, S.-H. Hsu, and T.-C. Tsou Depletion of Securin Increases Arsenite-Induced Chromosome Instability and Apoptosis via a p53-Independent Pathway Toxicol. Sci., March 1, 2006; 90(1): 73 - 86. [Abstract] [Full Text] [PDF]

				M. A. Rodriguez-Gabriel and P. Russell Distinct Signaling Pathways Respond to Arsenite and Reactive Oxygen Species in Schizosaccharomyces pombe Eukaryot. Cell, August 1, 2005; 4(8): 1396 - 1402. [Abstract] [Full Text] [PDF]

				S.-X. Liu, M. M. Davidson, X. Tang, W. F. Walker, M. Athar, V. Ivanov, and T. K. Hei Mitochondrial Damage Mediates Genotoxicity of Arsenic in Mammalian Cells Cancer Res., April 15, 2005; 65(8): 3236 - 3242. [Abstract] [Full Text] [PDF]

				X. Cui, Y. Kobayashi, T. Hayakawa, and S. Hirano Arsenic Speciation in Bile and Urine Following Oral and Intravenous Exposure to Inorganic and Organic Arsenics in Rats Toxicol. Sci., December 1, 2004; 82(2): 478 - 487. [Abstract] [Full Text] [PDF]

				K. M. Zierold, L. Knobeloch, and H. Anderson Prevalence of Chronic Diseases in Adults Exposed to Arsenic-Contaminated Drinking Water Am J Public Health, November 1, 2004; 94(11): 1936 - 1937. [Abstract] [Full Text] [PDF]

				D. S. Michaud, M. E. Wright, K. P. Cantor, P. R. Taylor, J. Virtamo, and D. Albanes Arsenic Concentrations in Prediagnostic Toenails and the Risk of Bladder Cancer in a Cohort Study of Male Smokers Am. J. Epidemiol., November 1, 2004; 160(9): 853 - 859. [Abstract] [Full Text] [PDF]

				D. A. Sens, S. Park, V. Gurel, M. A. Sens, S. H. Garrett, and S. Somji Inorganic Cadmium- and Arsenite-Induced Malignant Transformation of Human Bladder Urothelial Cells Toxicol. Sci., May 1, 2004; 79(1): 56 - 63. [Abstract] [Full Text] [PDF]

				H.-R. Guo, N.-S. Wang, H. Hu, and R. R. Monson Cell Type Specificity of Lung Cancer Associated with Arsenic Ingestion Cancer Epidemiol. Biomarkers Prev., April 1, 2004; 13(4): 638 - 643. [Abstract] [Full Text] [PDF]

				S.-C. Chen, M.-H. Tsai, H.-J. Wang, H.-S. Yu, and L. W Chang Vascular permeability alterations induced by arsenic Human and Experimental Toxicology, January 1, 2004; 23(1): 1 - 7. [Abstract] [PDF]

				Xing Cui, Song Li, A. Shraim, Y. Kobayashi, T. Hayakawa, S. Kanno, M. Yamamoto, and S. Hirano Subchronic Exposure to Arsenic Through Drinking Water Alters Expression of Cancer-Related Genes in Rat Liver Toxicol Pathol, January 1, 2004; 32(1): 64 - 72. [Abstract] [PDF]

				C. Steinmaus, Y. Yuan, M. N. Bates, and A. H. Smith Case-Control Study of Bladder Cancer and Drinking Water Arsenic in the Western United States Am. J. Epidemiol., December 15, 2003; 158(12): 1193 - 1201. [Abstract] [Full Text] [PDF]

				L.-H. Yih and T.-C. Lee Induction of C-Anaphase and Diplochromosome through Dysregulation of Spindle Assembly Checkpoint by Sodium Arsenite in Human Fibroblasts Cancer Res., October 15, 2003; 63(20): 6680 - 6688. [Abstract] [Full Text] [PDF]

				P. B. Tchounwou, A. K. Patlolla, and J. A. Centeno Invited Reviews: Carcinogenic and Systemic Health Effects Associated with Arsenic Exposure--A Critical Review Toxicol Pathol, October 1, 2003; 31(6): 575 - 588. [Abstract] [PDF]

				C. O. Abernathy, D. J. Thomas, and R. L. Calderon Health Effects and Risk Assessment of Arsenic J. Nutr., May 1, 2003; 133(5): 1536S - 1538. [Abstract] [Full Text] [PDF]

				E. I. Salim, H. Wanibuchi, K. Morimura, M. Wei, M. Mitsuhashi, K. Yoshida, G. Endo, and S. Fukushima Carcinogenicity of dimethylarsinic acid in p53 heterozygous knockout and wild-type C57BL/6J mice Carcinogenesis, February 1, 2003; 24(2): 335 - 342. [Abstract] [Full Text] [PDF]

				L.-H. Yih, K. Peck, and T.-C. Lee Changes in gene expression profiles of human fibroblasts in response to sodium arsenite treatment Carcinogenesis, May 1, 2002; 23(5): 867 - 876. [Abstract] [Full Text] [PDF]

				C.-J. Chen, S.-L. You, L.-H. Lin, W.-L. Hsu, and Y.-W. Yang Cancer Epidemiology and Control in Taiwan: a Brief Review Jpn. J. Clin. Oncol., February 1, 2002; 32(90001): S66 - 81. [Abstract] [Full Text] [PDF]

				P. P. Simeonova, S. Wang, M. L. Kashon, C. Kommineni, E. Crecelius, and M. I. Luster Quantitative Relationship between Arsenic Exposure and AP-1 Activity in Mouse Urinary Bladder Epithelium Toxicol. Sci., April 1, 2001; 60(2): 279 - 284. [Abstract] [Full Text] [PDF]

				H.-Y. Chiou, S.-T. Chiou, Y.-H. Hsu, Y.-L. Chou, C.-H. Tseng, M.-L. Wei, and C.-J. Chen Incidence of Transitional Cell Carcinoma and Arsenic in Drinking Water: A Follow-up Study of 8,102 Residents in an Arseniasis-endemic Area in Northeastern Taiwan Am. J. Epidemiol., March 1, 2001; 153(5): 411 - 418. [Abstract] [Full Text] [PDF]

				K. P. Cantor Invited Commentary: Arsenic and Cancer of the Urinary Tract Am. J. Epidemiol., March 1, 2001; 153(5): 419 - 421. [Abstract] [Full Text] [PDF]

				D. N G. Mazumder, R. Haque, N. Ghosh, B. K De, A. Santra, D. Chakraborti, and A. H Smith Arsenic in drinking water and the prevalence of respiratory effects in West Bengal, India Int. J. Epidemiol., December 1, 2000; 29(6): 1047 - 1052. [Abstract] [Full Text] [PDF]

				A. Stoica, E. Pentecost, and M. B. Martin Effects of Arsenite on Estrogen Receptor-{alpha} Expression and Activity in MCF-7 Breast Cancer Cells Endocrinology, October 1, 2000; 141(10): 3595 - 3602. [Abstract] [Full Text] [PDF]

				P. P. Simeonova, S. Wang, W. Toriuma, V. Kommineni, J. Matheson, N. Unimye, F. Kayama, D. Harki, M. Ding, V. Vallyathan, et al. Arsenic Mediates Cell Proliferation and Gene Expression in the Bladder Epithelium: Association with Activating Protein-1 Transactivation Cancer Res., July 1, 2000; 60(13): 3445 - 3453. [Abstract] [Full Text]

				M. Wei, H. Wanibuchi, S. Yamamoto, W. Li, and S. Fukushima Urinary bladder carcinogenicity of dimethylarsinic acid in male F344 rats Carcinogenesis, September 1, 1999; 20(9): 1873 - 1876. [Abstract] [Full Text] [PDF]

				H. J. Clewell, P. R. Gentry, H. A. Barton, A. M. Shipp, J. W. Yager, and M. E. Andersen Requirements for a Biologically Realistic Cancer Risk Assessment for Inorganic Arsenic International Journal of Toxicology, March 1, 1999; 18(2): 131 - 147. [Abstract] [PDF]

				D. R. Germolec, J. Spalding, H.-S. Yu, G. S. Chen, P. P. Simeonova, M. C. Humble, A. Bruccoleri, G. A. Boorman, J. F. Foley, T. Yoshida, et al. Arsenic Enhancement of Skin Neoplasia by Chronic Stimulation of Growth Factors Am. J. Pathol., December 1, 1998; 153(6): 1775 - 1785. [Abstract] [Full Text] [PDF]

				K.-M. Liaw and C.-J. Chen Mortality attributable to cigarette smoking in Taiwan: a 12-year follow-up study Tob. Control, June 1, 1998; 7(2): 141 - 148. [Abstract] [Full Text]