This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Takahashi, H. Articles by Boyd, J. Search for Related Content PubMed PubMed Citation Articles by Takahashi, H. Articles by Boyd, J.

Prevalence of Androgen Receptor Gene Mutations in Latent Prostatic Carcinomas from Japanese Men¹

Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina 27709 [H. T., H. N., J. C. B., J. B.]; Department of Pathology, Jikei University School of Medicine, Tokyo 105, Japan [M. F., S. W.]; and Department of Pathology, Medical College of Georgia, Augusta, Georgia 30912 [W. C. A.]

The incidence rate of clinically apparent prostatic carcinoma is 8-fold higher in the United States than in Japan, while the prevalence of latent prostatic carcinoma, a presumed precursor to clinical carcinoma, is similar in the two countries. The purpose of this study was to investigate the hypothesis that this profound difference in incidence rates of clinical carcinoma reflects distinct profiles of molecular genetic alterations in the latent precursor lesions that occur in the two countries. A significant fraction of latent carcinomas from Japanese men were found to contain inactivating mutations of the androgen receptor gene, while no such mutations were found in latent carcinomas from American men. No mutations were found in clinical carcinomas from either country. These data offer a potential molecular genetic explanation that may partially account for the distinct prostatic carcinoma incidence rates in these two populations.

¹ This research was supported in part by funds from the American Family Life Assurance Corporation, Columbus, GA (to W.C.A.) and from the Office of Research on Minority Health, NIH (to J. C. B.).

² To whom requests for reprints should be addressed, at Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, 778 Clinical Research Building, 415 Curie Boulevard, Philadelphia, PA 19104.

Received 1/31/95. Accepted 3/ 2/95.

This article has been cited by other articles:

				J Jaaskelainen, A Deeb, J W Schwabe, N P Mongan, H Martin, and I A Hughes Human androgen receptor gene ligand-binding-domain mutations leading to disrupted interaction between the N- and C-terminal domains. J. Mol. Endocrinol., April 1, 2006; 36(2): 361 - 368. [Abstract] [Full Text] [PDF]

				C. A. Heinlein and C. Chang Androgen Receptor in Prostate Cancer Endocr. Rev., April 1, 2004; 25(2): 276 - 308. [Abstract] [Full Text] [PDF]

				J. L. Mohler, C. W. Gregory, O. H. Ford III, D. Kim, C. M. Weaver, P. Petrusz, E. M. Wilson, and F. S. French The Androgen Axis in Recurrent Prostate Cancer Clin. Cancer Res., January 15, 2004; 10(2): 440 - 448. [Abstract] [Full Text] [PDF]

				M.-E. Taplin, B. Rajeshkumar, S. Halabi, C. P. Werner, B. A. Woda, J. Picus, W. Stadler, D. F. Hayes, P. W. Kantoff, N. J. Vogelzang, et al. Androgen Receptor Mutations in Androgen-Independent Prostate Cancer: Cancer and Leukemia Group B Study 9663 J. Clin. Oncol., July 15, 2003; 21(14): 2673 - 2678. [Abstract] [Full Text] [PDF]

				T. H. Thin, L. Wang, E. Kim, L. L. Collins, R. Basavappa, and C. Chang Isolation and Characterization of Androgen Receptor Mutant, AR(M749L), with Hypersensitivity to 17-beta Estradiol Treatment J. Biol. Chem., February 21, 2003; 278(9): 7699 - 7708. [Abstract] [Full Text] [PDF]

				K. A. Nelson and J. S. Witte Androgen Receptor CAG Repeats and Prostate Cancer Am. J. Epidemiol., May 15, 2002; 155(10): 883 - 890. [Abstract] [Full Text] [PDF]

				M. E. Taplin and S.-M. Ho The Endocrinology of Prostate Cancer J. Clin. Endocrinol. Metab., August 1, 2001; 86(8): 3467 - 3477. [Full Text] [PDF]

				J. Thompson, F. Saatcioglu, O. A. Janne, and J. J. Palvimo Disrupted Amino- and Carboxyl-Terminal Interactions of the Androgen Receptor Are Linked to Androgen Insensitivity Mol. Endocrinol., June 1, 2001; 15(6): 923 - 935. [Abstract] [Full Text] [PDF]

				T. Muto, S. Wakui, H. Takahashi, S. Maekawa, T. Masaoka, S. Ushigome, and M. Furusato p53 Gene Mutations Occurring in Spontaneous Benign and Malignant Mammary Tumors of the Dog Vet. Pathol., May 1, 2000; 37(3): 248 - 253. [Abstract] [Full Text] [PDF]

				M. Marcelli, M. Ittmann, S. Mariani, R. Sutherland, R. Nigam, L. Murthy, Y. Zhao, D. DiConcini, E. Puxeddu, A. Esen, et al. Androgen Receptor Mutations in Prostate Cancer Cancer Res., February 1, 2000; 60(4): 944 - 949. [Abstract] [Full Text]

				M. Marcelli and G. R. Cunningham Hormonal Signaling in Prostatic Hyperplasia and Neoplasia J. Clin. Endocrinol. Metab., October 1, 1999; 84(10): 3463 - 3468. [Full Text] [PDF]

				E. Ruijter, C. van de Kaa, G. Miller, D. Ruiter, F. Debruyne, and J. Schalken Molecular Genetics and Epidemiology of Prostate Carcinoma Endocr. Rev., February 1, 1999; 20(1): 22 - 45. [Abstract] [Full Text]

				C. Lopez-Otin and E. P. Diamandis Breast and Prostate Cancer: An Analysis of Common Epidemiological, Genetic, and Biochemical Features Endocr. Rev., August 1, 1998; 19(4): 365 - 396. [Abstract] [Full Text] [PDF]

				J.-a. Tan, Y. Sharief, K. G. Hamil, C. W. Gregory, D.-Y. Zang, M. Sar, P. H. Gumerlock, R. W. deVere White, T. G. Pretlow, S. E. Harris, et al. Dehydroepiandrosterone Activates Mutant Androgen Receptors Expressed in the Androgen-Dependent Human Prostate Cancer Xenograft CWR22 and LNCaP Cells Mol. Endocrinol., April 1, 1997; 11(4): 450 - 459. [Abstract] [Full Text]