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Association between Sialyl Lewis^a Expression and Tumor Progression in Melanoma

Department of Dermatology, Kumamoto University School of Medicine, 1-1 Honjo, Kumamoto 860 [T. Ka., S. H., T. Ki., T. O.], and Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Machida, Tokyo 194 [N. H., S. O.], Japan

Twenty-three primary and 27 metastatic melanoma lesions and 17 pigmented nevi lesions were tested utilizing the immunoperoxidase reaction with anti-sialyl Lewis^a (sLe^a) and anti-sLe^x mAbs. sLe^a was expressed in 9, 25, and 5 and sLe^x was expressed in 6, 11, and 2 of these lesions, respectively. Expression of sLe^a in melanocytic tumors is associated with tumor progression. Serum levels of sLe^a and sLe^x were analyzed by a sandwich assay using mAbs in 25 melanoma patients. Only 2 patients at stage 4 showed higher levels of sLe^a and sLe^x than did normal control subjects. Moreover, sLe^a and sLe^x were expressed in 1 and 2 of 5 human melanoma cell lines, respectively, and expression of sLe^a and sLe^x was not modulated by cytokines. These findings suggest that the expression of sLe^a in melanocytic tumors is correlated with disease progression.

¹ To whom requests for reprints should be addressed.

Received 11/18/94. Accepted 2/15/95.

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