| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Johns Hopkins Oncology Center [A. B., A. J. A., J. P. B., S. R. H., R. J. J.], Division of Gastroenterology, Departments of Medicine [P. J. P., F. M. G.], Surgery [G. C. B.], and Pathology [S. R. H.], The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, and Department of Hematology, Molecular Diagnostics Laboratory, Washington University School of Medicine, St. Louis, Missouri 63110 [B. A. Z.]
Colorectal tumorigenesis proceeds through an accumulation of specific genetic alterations. Studies of the mechanism by which these genetic changes effect malignant transformation have focused on the deregulation of cell proliferation. However, colorectal epithelial homoeostasis is dependent not only on the rate of cell production but also on apoptosis, a genetically programmed process of autonomous cell death. We investigated whether colorectal tumorigenesis involved an altered susceptibility to apoptosis by examining colorectal epithelium from normal mucosa, adenomas from familial adenomatous polyposis, sporadic adenomas, and carcinomas. The transformation of colorectal epithelium to carcinomas was associated with a progressive inhibition of apoptosis. The inhibition of apoptosis in colorectal cancers may contribute to tumor growth, promote neoplastic progression, and confer resistance to cytotoxic anticancer agents.
1 This work was supported by funds from NIH Grant P30 CA06973.
2 To whom requests for reprints should be addressed, at Johns Hopkins Oncology Center, 600 N. Wolfe Street, Baltimore, MD 21287.
Received 12/13/94. Accepted 3/17/95.
This article has been cited by other articles:
|
|
 |
|
  C. Gao and A.-Y. Wang Significance of Increased Apoptosis and Bax Expression in Human Small Intestinal Adenocarcinoma J. Histochem. Cytochem., December 1, 2009; 57(12): 1139 - 1148. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Nagasaka, N. Tanaka, H. M. Cullings, D.-S. Sun, H. Sasamoto, T. Uchida, M. Koi, N. Nishida, Y. Naomoto, C. R. Boland, et al. Analysis of Fecal DNA Methylation to Detect Gastrointestinal Neoplasia J Natl Cancer Inst, September 16, 2009; 101(18): 1244 - 1258. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-Y. Fan, Y. Zhan, H. M. Aukema, L. A. Davidson, L. Zhou, E. Callaway, Y. Tian, B. R. Weeks, J. R. Lupton, S. Toyokuni, et al. Proapoptotic Effects of Dietary (n-3) Fatty Acids Are Enhanced in Colonocytes of Manganese-Dependent Superoxide Dismutase Knockout Mice J. Nutr., July 1, 2009; 139(7): 1328 - 1332. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Qiu, E. B. Carson-Walter, S. F. Kuan, L. Zhang, and J. Yu PUMA Suppresses Intestinal Tumorigenesis in Mice Cancer Res., June 15, 2009; 69(12): 4999 - 5006. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Garcia-Crespo, E. Knock, N. Jabado, and R. Rozen Intestinal Neoplasia Induced by Low Dietary Folate Is Associated with Altered Tumor Expression Profiles and Decreased Apoptosis in Mouse Normal Intestine J. Nutr., March 1, 2009; 139(3): 488 - 494. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. A. Sinicrope, R. L. Rego, N. R. Foster, S. N. Thibodeau, S. R. Alberts, H. E. Windschitl, and D. J. Sargent Proapoptotic Bad and Bid Protein Expression Predict Survival in Stages II and III Colon Cancers Clin. Cancer Res., July 1, 2008; 14(13): 4128 - 4133. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. M. Boman and E. Huang Human Colon Cancer Stem Cells: A New Paradigm in Gastrointestinal Oncology J. Clin. Oncol., June 10, 2008; 26(17): 2828 - 2838. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. T. Tan, S. Tan, Q. Lin, T. K. Lim, C. L. Hew, and M. C. M. Chung Quantitative and Temporal Proteome Analysis of Butyrate-treated Colorectal Cancer Cells Mol. Cell. Proteomics, June 1, 2008; 7(6): 1174 - 1185. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Jia, J. R. Lupton, R. Smith, B. R. Weeks, E. Callaway, L. A. Davidson, W. Kim, Y.-Y. Fan, P. Yang, R. A. Newman, et al. Reduced Colitis-Associated Colon Cancer in Fat-1 (n-3 Fatty Acid Desaturase) Transgenic Mice Cancer Res., May 15, 2008; 68(10): 3985 - 3991. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. M. Boman, J. Z. Fields, K. L. Cavanaugh, A. Guetter, and O. A. Runquist How Dysregulated Colonic Crypt Dynamics Cause Stem Cell Overpopulation and Initiate Colon Cancer Cancer Res., May 1, 2008; 68(9): 3304 - 3313. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Wang, K. Srinivasan, M. R. Siddiqui, S. P. George, A. Tomar, and S. Khurana A Novel Role for Villin in Intestinal Epithelial Cell Survival and Homeostasis J. Biol. Chem., April 4, 2008; 283(14): 9454 - 9464. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Vanamala, A. Glagolenko, P. Yang, R.J. Carroll, M.E. Murphy, R.A. Newman, J.R. Ford, L.A. Braby, R.S. Chapkin, N.D. Turner, et al. Dietary fish oil and pectin enhance colonocyte apoptosis in part through suppression of PPAR{delta}/PGE2 and elevation of PGE3 Carcinogenesis, April 1, 2008; 29(4): 790 - 796. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. O. Keku, A. Amin, J. Galanko, C. Martin, B. Schliebe, and R. S. Sandler Apoptosis in Normal Rectal Mucosa, Baseline Adenoma Characteristics, and Risk of Future Adenomas Cancer Epidemiol. Biomarkers Prev., February 1, 2008; 17(2): 306 - 310. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Banerjee, C. Kr. Panda, and S. Das Clove (Syzygium aromaticum L.), a potential chemopreventive agent for lung cancer Carcinogenesis, August 1, 2006; 27(8): 1645 - 1654. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. V. Swamy, J. M.R. Patlolla, V. E. Steele, L. Kopelovich, B. S. Reddy, and C. V. Rao Chemoprevention of Familial Adenomatous Polyposis by Low Doses of Atorvastatin and Celecoxib Given Individually and in Combination to APCMin Mice. Cancer Res., July 15, 2006; 66(14): 7370 - 7377. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. S. Reddy, C. X. Wang, A.-N. Kong, T. O. Khor, X. Zheng, V. E. Steele, L. Kopelovich, and C. V. Rao Prevention of azoxymethane-induced colon cancer by combination of low doses of atorvastatin, aspirin, and celecoxib in f 344 rats. Cancer Res., April 15, 2006; 66(8): 4542 - 4546. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. P. N. Majumdar and J. Du Phosphatidylinositol 3-kinase/Akt signaling stimulates colonic mucosal cell survival during aging Am J Physiol Gastrointest Liver Physiol, January 1, 2006; 290(1): G49 - G55. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. V. Grau, J. A. Baron, E. L. Barry, R. S. Sandler, R. W. Haile, J. S. Mandel, and B. F. Cole Interaction of Calcium Supplementation and Nonsteroidal Anti-inflammatory Drugs and the Risk of Colorectal Adenomas Cancer Epidemiol. Biomarkers Prev., October 1, 2005; 14(10): 2353 - 2358. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. O. Keku, P. K. Lund, J. Galanko, J. G. Simmons, J. T. Woosley, and R. S. Sandler Insulin Resistance, Apoptosis, and Colorectal Adenoma Risk Cancer Epidemiol. Biomarkers Prev., September 1, 2005; 14(9): 2076 - 2081. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Avis, A. Martinez, J. Tauler, E. Zudaire, A. Mayburd, R. Abu-Ghazaleh, F. Ondrey, and J. L. Mulshine Inhibitors of the Arachidonic Acid Pathway and Peroxisome Proliferator-Activated Receptor Ligands Have Superadditive Effects on Lung Cancer Growth Inhibition Cancer Res., May 15, 2005; 65(10): 4181 - 4190. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-Y. Hao, D. H. Moore, P. Wong, J. L. Bennington, N. M. Lee, and L.-C. Chen Alteration of Gene Expression in Macroscopically Normal Colonic Mucosa from Individuals with a Family History of Sporadic Colon Cancer Clin. Cancer Res., February 15, 2005; 11(4): 1400 - 1407. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. Miller, T. O. Keku, J. A. Satia, C. F. Martin, J. A. Galanko, and R. S. Sandler Calcium, Vitamin D, and Apoptosis in the Rectal Epithelium Cancer Epidemiol. Biomarkers Prev., February 1, 2005; 14(2): 525 - 528. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Steigerwald, G. K. Behbehani, K. A. Combs, M. C. Barton, and J. Groden The APC Tumor Suppressor Promotes Transcription-Independent Apoptosis In vitro Mol. Cancer Res., February 1, 2005; 3(2): 78 - 89. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Ravi, A. J. Jain, R. D. Schulick, V. Pham, T. S. Prouser, H. Allen, E. G. Mayer, H. Yu, D. M. Pardoll, A. Ashkenazi, et al. Elimination of Hepatic Metastases of Colon Cancer Cells via p53-Independent Cross-Talk between Irinotecan and Apo2 Ligand/TRAIL Cancer Res., December 15, 2004; 64(24): 9105 - 9114. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. M. Boman, R. Walters, J. Z. Fields, A. J. Kovatich, T. Zhang, G. A. Isenberg, S. D. Goldstein, and J. P. Palazzo Colonic Crypt Changes during Adenoma Development in Familial Adenomatous Polyposis: Immunohistochemical Evidence for Expansion of the Crypt Base Cell Population Am. J. Pathol., November 1, 2004; 165(5): 1489 - 1498. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. J. Sansom, K. R. Reed, A. J. Hayes, H. Ireland, H. Brinkmann, I. P. Newton, E. Batlle, P. Simon-Assmann, H. Clevers, I. S. Nathke, et al. Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration Genes & Dev., June 15, 2004; 18(12): 1385 - 1390. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. A. Sinicrope, E. Half, J. S. Morris, P. M. Lynch, J. D. Morrow, B. Levin, E. T. Hawk, D. S. Cohen, G. D. Ayers, and L. C. Stephens Cell Proliferation and Apoptotic Indices Predict Adenoma Regression in a Placebo-Controlled Trial of Celecoxib in Familial Adenomatous Polyposis Patients Cancer Epidemiol. Biomarkers Prev., June 1, 2004; 13(6): 920 - 927. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Garrity, L. J. Burgart, M. R. Mahoney, H. E. Windschitl, M. Salim, M. Wiesenfeld, J. E. Krook, J. C. Michalak, R. M. Goldberg, M. J. O'Connell, et al. Prognostic Value of Proliferation, Apoptosis, Defective DNA Mismatch Repair, and p53 Overexpression in Patients With Resected Dukes' B2 or C Colon Cancer: A North Central Cancer Treatment Group Study J. Clin. Oncol., May 1, 2004; 22(9): 1572 - 1582. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Bernstein, C. M. Payne, K. Kunke, C. L. Crowley-Weber, C. N. Waltmire, K. Dvorakova, H. Holubec, C. Bernstein, R. R. Vaillancourt, D. A. Raynes, et al. A proteomic study of resistance to deoxycholate-induced apoptosis Carcinogenesis, May 1, 2004; 25(5): 681 - 692. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. E. Castelao, R. D. Bart III, C. A. DiPerna, E. M. Sievers, and R. M. Bremner Lung cancer and cyclooxygenase-2 Ann. Thorac. Surg., October 1, 2003; 76(4): 1327 - 1335. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-Y. Fan, T. E. Spencer, N. Wang, M. P. Moyer, and R. S. Chapkin Chemopreventive n-3 fatty acids activate RXR{alpha} in colonocytes Carcinogenesis, September 1, 2003; 24(9): 1541 - 1548. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Nishihara, S. Kizaka-Kondoh, P. A. Insel, and L. Eckmann Inhibition of apoptosis in normal and transformed intestinal epithelial cells by cAMP through induction of inhibitor of apoptosis protein (IAP)-2 PNAS, July 22, 2003; 100(15): 8921 - 8926. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. Boynton, I. C. Summerhayes, D. A. Ahlquist, and A. P. Shuber DNA Integrity as a Potential Marker for Stool-based Detection of Colorectal Cancer Clin. Chem., July 1, 2003; 49(7): 1058 - 1065. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Connelly, J. Satia-Abouta, C. F. Martin, T. O. Keku, J. T. Woosley, P. K. Lund, and R. S. Sandler Vitamin C Intake and Apoptosis in Normal Rectal Epithelium Cancer Epidemiol. Biomarkers Prev., June 1, 2003; 12(6): 559 - 565. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. K. Smith, R. Mithen, and I. T. Johnson Effects of Brassica vegetable juice on the induction of apoptosis and aberrant crypt foci in rat colonic mucosal crypts in vivo Carcinogenesis, March 1, 2003; 24(3): 491 - 495. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. Crowley-Weber, C. M. Payne, M. Gleason-Guzman, G. S. Watts, B. Futscher, C. N. Waltmire, C. Crowley, K. Dvorakova, C. Bernstein, M. Craven, et al. Development and molecular characterization of HCT-116 cell lines resistant to the tumor promoter and multiple stress-inducer, deoxycholate Carcinogenesis, December 1, 2002; 23(12): 2063 - 2080. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Keller, G. Johan, A. Offerhaus, L. M. Hylind, and F. M. Giardiello Rectal Epithelial Apoptosis Does Not Predict Response to Sulindac Treatment or Polyp Development in Presymptomatic Familial Adenomatous Polyposis Patients Cancer Epidemiol. Biomarkers Prev., July 1, 2002; 11(7): 670 - 671. [Full Text] [PDF]
|
|
|
|
|
|
Y. Hu, J. Martin, R. Le Leu, and G.P. Young The colonic response to genotoxic carcinogens in the rat: regulation by dietary fibre Carcinogenesis, July 1, 2002; 23(7): 1131 - 1137. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R.K. Le Leu, Y. Hu, and G.P. Young Effects of resistant starch and nonstarch polysaccharides on colonic luminal environment and genotoxin-induced apoptosis in the rat Carcinogenesis, May 1, 2002; 23(5): 713 - 719. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Rak, J. L. Yu, R. S. Kerbel, and B. L. Coomber What Do Oncogenic Mutations Have To Do with Angiogenesis/Vascular Dependence of Tumors? Cancer Res., April 1, 2002; 62(7): 1931 - 1934. [Full Text] [PDF]
|
|
|
|
|
|
R. Ravi and A. Bedi Requirement of BAX for TRAIL/Apo2L-induced Apoptosis of Colorectal Cancers: Synergism with Sulindac-mediated Inhibition of Bcl-xL Cancer Res., March 1, 2002; 62(6): 1583 - 1587. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H H J Backus, C J Van Groeningen, W Vos, D F Dukers, E Bloemena, D Wouters, H M Pinedo, and G J Peters Differential expression of cell cycle and apoptosis related proteins in colorectal mucosa, primary colon tumours, and liver metastases J. Clin. Pathol., March 1, 2002; 55(3): 206 - 211. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Thun, S. J. Henley, and C. Patrono Nonsteroidal Anti-inflammatory Drugs as Anticancer Agents: Mechanistic, Pharmacologic, and Clinical Issues J Natl Cancer Inst, February 20, 2002; 94(4): 252 - 266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. O'Shaughnessy, G. J. Kelloff, G. B. Gordon, A. J. Dannenberg, W. K. Hong, C. J. Fabian, C. C. Sigman, M. M. Bertagnolli, S. P. Stratton, S. Lam, et al. Treatment and Prevention of Intraepithelial Neoplasia: An Important Target for Accelerated New Agent Development : Recommendations of the American Association for Cancer Research Task Force on the Treatment and Prevention of Intraepithelial Neoplasia Clin. Cancer Res., February 1, 2002; 8(2): 314 - 346. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. M. Boman, J. Z. Fields, O. Bonham-Carter, and O. A. Runquist Computer Modeling Implicates Stem Cell Overproduction in Colon Cancer Initiation Cancer Res., December 1, 2001; 61(23): 8408 - 8411. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Zhang, T. Otevrel, Z. Gao, Z. Gao, S. M. Ehrlich, J. Z. Fields, and B. M. Boman Evidence That APC Regulates Survivin Expression: A Possible Mechanism Contributing to the Stem Cell Origin of Colon Cancer Cancer Res., December 1, 2001; 61(24): 8664 - 8667. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Elliott, Y. B. Dong, H. Yang, and K. M. McMasters E2F-1 Up-Regulates c-Myc and p14ARF and Induces Apoptosis in Colon Cancer Cells Clin. Cancer Res., November 1, 2001; 7(11): 3590 - 3597. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W A Brown, S A Skinner, C Malcontenti-Wilson, D Vogiagis, and P E O'Brien Non-steroidal anti-inflammatory drugs with activity against either cyclooxygenase 1 or cyclooxygenase 2 inhibit colorectal cancer in a DMH rodent model by inducing apoptosis and inhibiting cell proliferation Gut, May 1, 2001; 48(5): 660 - 666. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Caderni, C. Luceri, C. De Filippo, M. Salvadori, A. Giannini, L. Tessitore, and P. Dolara Slow-release pellets of sodium butyrate do not modify azoxymethane (AOM)-induced intestinal carcinogenesis in F344 rats Carcinogenesis, March 1, 2001; 22(3): 525 - 527. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Anti, A Armuzzi, S Morini, E Iascone, G Pignataro, C Coco, R Lorenzetti, M Paolucci, M Covino, A Gasbarrini, et al. Severe imbalance of cell proliferation and apoptosis in the left colon and in the rectosigmoid tract in subjects with a history of large adenomas Gut, February 1, 2001; 48(2): 238 - 246. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Richter, M. Weiss, I. Weinberger, G. Furstenberger, and B. Marian Growth inhibition and induction of apoptosis in colorectal tumor cells by cyclooxygenase inhibitors Carcinogenesis, January 1, 2001; 22(1): 17 - 25. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Guerrero, I. Casanova, L. Farré, A. Mazo, G. Capellà, and R. Mangues K-ras Codon 12 Mutation Induces Higher Level of Resistance to Apoptosis and Predisposition to Anchorage-independent Growth Than Codon 13 Mutation or Proto-Oncogene Overexpression Cancer Res., December 1, 2000; 60(23): 6750 - 6756. [Abstract] [Full Text]
|
|
|
|
|
|
K. R. Lawson, N. A. Ignatenko, G. A. Piazza, H. Cui, and E. W. Gerner Influence of K-ras Activation on the Survival Responses of Caco-2 Cells to the Chemopreventive Agents Sulindac and Difluoromethylornithine Cancer Epidemiol. Biomarkers Prev., November 1, 2000; 9(11): 1155 - 1162. [Abstract] [Full Text]
|
|
|
|
 |
|
 G. Le'Negrate, E. Selva, P. Auberger, B. Rossi, and P. Hofman Sustained Polymorphonuclear Leukocyte Transmigration Induces Apoptosis in T84 Intestinal Epithelial Cells J. Cell Biol., September 18, 2000; 150(6): 1479 - 1488. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. K. Yoshimura, T. Wang, F. Yu, H.-R. C. Kim, and J. R. Turner Mink Cell Focus-Forming Murine Leukemia Virus Infection Induces Apoptosis of Thymic Lymphocytes J. Virol., September 1, 2000; 74(17): 8119 - 8126. [Abstract] [Full Text]
|
|
|
|
|
|
M. Y. Hong, J. R. Lupton, J. S. Morris, N. Wang, R. J. Carroll, L. A. Davidson, R. H. Elder, and R. S. Chapkin Dietary Fish Oil Reduces O6-Methylguanine DNA Adduct Levels in Rat Colon in Part by Increasing Apoptosis during Tumor Initiation Cancer Epidemiol. Biomarkers Prev., August 1, 2000; 9(8): 819 - 826. [Abstract] [Full Text]
|
|
|
|
|
|
L. A. Davidson, R. E. Brown, W.-C. L. Chang, J. S. Morris, N. Wang, R. J. Carroll, N. D. Turner, J. R. Lupton, and R. S. Chapkin Morphodensitometric analysis of protein kinase C {beta}II expression in rat colon: modulation by diet and relation to in situ cell proliferation and apoptosis Carcinogenesis, August 1, 2000; 21(8): 1513 - 1519. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Jenab and L. U. Thompson Phytic acid in wheat bran affects colon morphology, cell differentiation and apoptosis Carcinogenesis, August 1, 2000; 21(8): 1547 - 1552. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kondo, Y. Shinomura, Y. Miyazaki, T. Kiyohara, S. Tsutsui, S. Kitamura, Y. Nagasawa, M. Nakahara, S. Kanayama, and Y. Matsuzawa Mutations of the bak Gene in Human Gastric and Colorectal Cancers Cancer Res., August 1, 2000; 60(16): 4328 - 4330. [Abstract] [Full Text]
|
|
|
|
|
|
V. Kozoni, G. Tsioulias, S. Shiff, and B. Rigas The effect of lithocholic acid on proliferation and apoptosis during the early stages of colon carcinogenesis: differential effect on apoptosis in the presence of a colon carcinogen Carcinogenesis, May 1, 2000; 21(5): 999 - 1005. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A I Sarela, R C A Macadam, S M Farmery, A F Markham, and P J Guillou Expression of the antiapoptosis gene, Survivin, predicts death from recurrent colorectal carcinoma Gut, May 1, 2000; 46(5): 645 - 650. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Sugao, T. Koji, T. Yao, T. Ueki, and M. Tsuneyoshi The Incidence of Apoptosis During Colorectal Tumorigenesis International Journal of Surgical Pathology, April 1, 2000; 8(2): 123 - 132. [Abstract] [PDF]
|
|
|
|
|
|
I D Penman, Q L Liang, J Bode, M A Eastwood, and M J Arends Dietary calcium supplementation increases apoptosis in the distal murine colonic epithelium J. Clin. Pathol., April 1, 2000; 53(4): 302 - 307. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Scholzel, W. Zimmermann, G. Schwarzkopf, F. Grunert, B. Rogaczewski, and J. Thompson Carcinoembryonic Antigen Family Members CEACAM6 and CEACAM7 Are Differentially Expressed in Normal Tissues and Oppositely Deregulated in Hyperplastic Colorectal Polyps and Early Adenomas Am. J. Pathol., February 1, 2000; 156(2): 595 - 605. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Williams, T. J. Collard, C. M. Perks, P. Newcomb, M. Moorghen, J. M. P. Holly, and C. Paraskeva Increased p53-dependent Apoptosis by the Insulin-like Growth Factor Binding Protein IGFBP-3 in Human Colonic Adenoma-derived Cells Cancer Res., January 1, 2000; 60(1): 22 - 27. [Abstract] [Full Text]
|
|
|
|
|
|
K. Tanaka, S. Iwamoto, G. Gon, T. Nohara, M. Iwamoto, and N. Tanigawa Expression of survivin and Its Relationship to Loss of Apoptosis in Breast Carcinomas Clin. Cancer Res., January 1, 2000; 6(1): 127 - 134. [Abstract] [Full Text]
|
|
|
|
|
|
J J Keller, G J A Offerhaus, M Polak, S N Goodman, M L Zahurak, L M Hylind, S R Hamilton, and F M Giardiello Rectal epithelial apoptosis in familial adenomatous polyposis patients treated with sulindac Gut, December 1, 1999; 45(6): 822 - 828. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. H. Augenlicht, G. M. Anthony, T. L. Church, W. Edelmann, R. Kucherlapati, K. Yang, M. Lipkin, and B. G. Heerdt Short-Chain Fatty Acid Metabolism, Apoptosis, and Apc-initiated Tumorigenesis in the Mouse Gastrointestinal Mucosa Cancer Res., December 1, 1999; 59(23): 6005 - 6009. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Sabbatini and F. McCormick Phosphoinositide 3-OH Kinase (PI3K) and PKB/Akt Delay the Onset of p53-mediated, Transcriptionally Dependent Apoptosis J. Biol. Chem., August 20, 1999; 274(34): 24263 - 24269. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-Y. Fan, J. Zhang, R. Barhoumi, R. C. Burghardt, N. D. Turner, J. R. Lupton, and R. S. Chapkin Antagonism of CD95 signaling blocks butyrate induction of apoptosis in young adult mouse colonic cells Am J Physiol Cell Physiol, August 1, 1999; 277(2): C310 - C319. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L U Liu, P R Holt, V Krivosheyev, and S F Moss Human right and left colon differ in epithelial cell apoptosis and in expression of Bak, a pro-apoptotic Bcl-2 homologue Gut, July 1, 1999; 45(1): 45 - 50. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. A. Sinicrope, J. Hart, H.-A. Hsu, M. Lemoine, F. Michelassi, and L. C. Stephens Apoptotic and Mitotic Indices Predict Survival Rates in Lymph Node-negative Colon Carcinomas Clin. Cancer Res., July 1, 1999; 5(7): 1793 - 1804. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Bernstein, H. Bernstein, H. Garewal, P. Dinning, R. Jabi, R. E. Sampliner, M. K. McCuskey, M. Panda, D. J. Roe, L. L'Heureux, et al. A Bile Acid-induced Apoptosis Assay for Colon Cancer Risk and Associated Quality Control Studies Cancer Res., May 1, 1999; 59(10): 2353 - 2357. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Li, H. A.J. Schut, P. Conran, P. M. Kramer, R. A. Lubet, V. E. Steele, E. E. Hawk, G. J. Kelloff, and M. A. Pereira Prevention by aspirin and its combination with {alpha}-difluoromethylornithine of azoxymethane-induced tumors, aberrant crypt foci and prostaglandin E2 levels in rat colon Carcinogenesis, March 1, 1999; 20(3): 425 - 430. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kawamori, R. Lubet, V. E. Steele, G. J. Kelloff, R. B. Kaskey, and C. V. Rao Chemopreventive Effect of Curcumin, a Naturally Occurring Anti-Inflammatory Agent, during the Promotion/Progression Stages of Colon Cancer Cancer Res., February 1, 1999; 59(3): 597 - 601. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. N. Mahmoud, R. T. Bilinski, M. R. Churchill, W. Edelmann, R. Kucherlapati, and M. M. Bertagnolli Genotype-Phenotype Correlation in Murine Apc Mutation: Differences in Enterocyte Migration and Response to Sulindac Cancer Res., January 1, 1999; 59(2): 353 - 359. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ikawa, H. Kamitani, B. F. Calvo, J. F. Foley, and T. E. Eling Expression of 15-Lipoxygenase-1 in Human Colorectal Cancer Cancer Res., January 1, 1999; 59(2): 360 - 366. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Aotake, C.-D. Lu, Y. Chiba, R. Muraok, and N. Tanigawa Changes of Angiogenesis and Tumor Cell Apoptosis during Colorectal Carcinogenesis Clin. Cancer Res., January 1, 1999; 5(1): 135 - 142. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Giaretti, A. Rapallo, E. Geido, A. Sciutto, F. Merlo, M. Risio, and F. P. Rossini Specific K-ras2 Mutations in Human Sporadic Colorectal Adenomas Are Associated with DNA Near-Diploid Aneuploidy and Inhibition of Proliferation Am. J. Pathol., October 1, 1998; 153(4): 1201 - 1209. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Zhang, G. Wu, R. S. Chapkin, and J. R. Lupton Energy Metabolism of Rat Colonocytes Changes during the Tumorigenic Process and Is Dependent on Diet and Carcinogen J. Nutr., August 1, 1998; 128(8): 1262 - 1269. [Abstract] [Full Text]
|
|
|
|
|
|
W.-C. L. Chang, R. S. Chapkin, and J. R. Lupton Fish Oil Blocks Azoxymethane-Induced Rat Colon Tumorigenesis by Increasing Cell Differentiation and Apoptosis Rather Than Decreasing Cell Proliferation J. Nutr., March 1, 1998; 128(3): 491 - 497. [Abstract] [Full Text]
|
|
|
|
|
|
B. A. Jones and G. J. Gores Physiology and pathophysiology of apoptosis in epithelial cells of the liver, pancreas, and intestine Am J Physiol Gastrointest Liver Physiol, December 1, 1997; 273(6): G1174 - G1188. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Brodsky, M. S. Vala, J. P. Barber, M. E. Medof, and R. J. Jones Resistance to apoptosis caused by PIG-A gene mutations in paroxysmal nocturnal hemoglobinuria PNAS, August 5, 1997; 94(16): 8756 - 8760. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Houghton, F. G. Harwood, and D. M. Tillman Thymineless death in colon carcinoma cells is mediated via Fas signaling PNAS, July 22, 1997; 94(15): 8144 - 8149. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Coopersmith, C. Chandrasekaran, M. S. McNevin, and J. I. Gordon Bi-transgenic Mice Reveal that K-rasVal12 Augments a p53-independent Apoptosis When Small Intestinal Villus Enterocytes Reenter the Cell Cycle J. Cell Biol., July 14, 1997; 138(1): 167 - 179. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Katada, R. A. Hinder, T. C. Smyrk, N. Hirabayashi, G. Perdikis, R. J. Lund, T. Woodward, and P. J. Klingler Apoptosis Is Inhibited Early in the Dysplasia-Carcinoma Sequence of Barrett Esophagus Arch Surg, July 1, 1997; 132(7): 728 - 733. [Abstract] [PDF]
|
|
|
|
|
|
E. Miyoshi, S. Higashiyama, T. Nakagawa, N. Hayashi, and N. Taniguchi Membrane-anchored Heparin-binding Epidermal Growth Factor-like Growth Factor Acts as a Tumor Survival Factor in a Hepatoma Cell Line J. Biol. Chem., May 30, 1997; 272(22): 14349 - 14355. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Screaton, L. Z. Penn, and C. P. Stanners Carcinoembryonic Antigen, a Human Tumor Marker, Cooperates with Myc and Bcl-2 in Cellular Transformation J. Cell Biol., May 19, 1997; 137(4): 939 - 952. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
