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Division of Molecular Cytometry, Department of Laboratory Medicine [H. M., F. M. W.] and Department of Urology [J. C. P.], University of California San Francisco, San Francisco, California 94143-0808, and Institute of Pathology [G. S., M. J. M.], Clinic for Urology [N. B.], and University Computer Center [P. J.], University of Basel, 4003 Basel, Switzerland
The clinical behavior of renal cell carcinoma (RCC) cannot be predicted by histological and other markers. In this study, comparative genomic hybridization was used to evaluate whether the number of genomic aberrations has prognostic significance in 41 nonmetastatic clear cell RCC extending beyond the renal capsule. Losses were most prevalent at 3p (56%) and 9p and 13q (24% each). The number of DNA losses per tumor was associated with recurrence-free survival (P = 0.03). DNA gains most often involved chromosome 5q (17%) and chromosome 7 (15%). The number of DNA gains was not associated with clinical outcome. Loss of chromosome 9p was the only individual locus associated with recurrence (P = 0.04), suggesting that a tumor suppressor gene on chromosome 9p may play a role in RCC progression.
1 This study was supported by Deutsche Forschungsgemeinschaft (Mo 625/1), Swiss National Science Foundation (3200-043969.95/1), and CA47537. J. C. P. is recipient of American Cancer Society Clinical Oncology Career Development Award 93–62.
2 To whom requests for reprints should be addressed, at Department of Laboratory Medicine, Division of Molecular Cytometry, University of California, MCB 230, San Francisco, CA 94143-0808.
Received 9/ 1/95. Accepted 11/14/95.
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