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[Cancer Research 56, 2285-2288, May 15, 1996]
© 1996 American Association for Cancer Research
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Microsatellite Alterations in Bronchial and Sputum Specimens of Lung Cancer Patients1

Monica Miozzo, Gabriella Sozzi2, Katia Musso, Silvana Pilotti, Matteo Incarbone, Ugo Pastorino and Marco A. Pierotti

Divisions of Experimental Oncology A [M. M., G. S., K. M., M. A. P.], Anatomical Pathology and Cytology [S. P.], and Chest Surgery [M. I., U. P.], Istituto Nazionale Tumori, Via G. Venezian 1, 20133 Milano, Italy

Early diagnosis of lung cancer based on conventional screening procedures has been unable thus far to decrease lung cancer mortality. We explored the possibility of using microsatellite instability in the detection and screening of early phases of lung carcinogenesis. We studied tumor, histopathologically normal bronchial mucosa, and cytological specimens of 51 lung cancer patients for the presence of clonal variations at microsatellite polymorphisms. Microsatellite alterations were found in tumor, normal bronchial mucosa and cytological specimens of 25 of 51 (49%) of the patients. The detection of microsatellite alterations in histopathologically normal bronchial specimens and cytological clinical samples with minimal atypia suggests a possible application of this genetic marker in early diagnosis of precancerous lesions and lung cancer.

1 This work is partially supported by the Associazione Italiana per la Ricerca sul Cancro, Fondazione Italiana Ricerca Cancro, and the Special Project of the Consiglio Nazionale Ricerche "Applicazioni Cliniche della Ricerca Oncologies."

2 To whom requests for reprints should be addressed.

Received 2/12/96. Accepted 3/29/96.




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HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 1996 by the American Association for Cancer Research.