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Frequent Microsatellite Instability in Epithelial Borderline Ovarian Tumors¹

Laboratory of Gynecologic Oncology, Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology [J. T., N. S. L., R. S. B., M. G. M., S. C. M.], and Department of Pathology [W. R. W.], Brigham and Women's Hospital, and Department of Pathology [D. A. B.], Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02115

To further define the genetic events that could lead to the development of borderline ovarian tumors (BOTs), we analyzed 13 microsatellite markers on chromosomes 3p and q in 18 BOTs and compared the results to 31 serous invasive epithelial ovarian cancers (IEOCs). Five of the 18 BOTs showed microsatellite instability (MSI) at one or more loci, compared to only 2 of the 31 IEOCs studied (P < 0.04). In two of these five BOTs, MSI was found in multiple loci. All BOTs with MSI were serous, while none of the mucinous type showed any alteration. Loss of heterozygosity was found in only 1 of the 18 BOTs, but in 12 of the 31 IEOCs (P < 0.01). This first report of a relatively high percentage of MSI in BOTs opens a wide spectrum of new hypotheses for borderline ovarian tumorigenesis as well as several new research avenues.

¹ Supported by PHS Grant R01CA63381 from the NIH, Department of Health and Human Services.

² These authors have contributed equally to this work.

³ To whom requests for reprints should be addressed, at Laboratory of Gynecologic Oncology, Brigham and Women's Hospital, 221 Longwood Avenue, RF 468, Boston, MA 02115.

Received 3/17/96. Accepted 4/17/96.

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