This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hui, A. B. Y. Articles by Huang, D. P. Search for Related Content PubMed PubMed Citation Articles by Hui, A. B. Y. Articles by Huang, D. P.

Loss of Heterozygosity on the Long Arm of Chromosome 11 in Nasopharyngeal Carcinoma¹

Departments of Anatomical and Cellular Pathology [A. B. Y. H., K-W. L., J. C. K. L., D. P. H.] and Clinical Oncology [S-F. L., P. H. K. C.], Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, N. T., Hong Kong, and Cancer Institute, Sun Yat-Sen University of Medical Sciences Cancer Center, Canter Hospital, Dongfeng Road East, Guangzhou, People's Republic of China [Y. F.]

Loss of heterozygosity (LOH) on the long arm of chromosome 11 had been reported in many types of solid tumors. In this study, we investigated the LOH patterns of chromosome 11 on 52 primary nasopharyngeal carcinomas using 10 microsatellite polymorphic markers. The results revealed that 28 of the 52 cases (53.8%) demonstrated LOH on at least one of the nine 11q microsatellite loci studied. The highest frequencies of LOH were found at the two loci D11S2000 (36.1%) and D11S934 (34.5%), both located at 11q22–24. Two distinct regions of deletion were found at 11q, with the first one defined by INT-2 and D11S900 at 11q13.3–22, and the second region located between D11S2000 and D11S934 at 11q22–24. The two deletion regions overlap with the common areas of deletion reported in other tumor types. This suggests the presence of multiple putative tumor suppressor genes on chromosome 11q that may play a role in the development of nasopharyngeal carcinomas.

¹ This study was supported by Hong Kong Grant CUHK52/93M from the University and Polytechnic Grants Committee, Hong Kong.

² To whom requests for reprints should be addressed. Phone (852) 2632-1130; Fax: (852) 2637-6274.

Received 4/16/96. Accepted 5/29/96.

This article has been cited by other articles:

				A. B.-Y. Hui, Y. Y.-Y. Or, H. Takano, R. K.-Y. Tsang, K.-F. To, X.-Y. Guan, J. S.-T. Sham, K. W.-K. Hung, C. N.-Y. Lam, C. A. van Hasselt, et al. Array-Based Comparative Genomic Hybridization Analysis Identified Cyclin D1 as a Target Oncogene at 11q13.3 in Nasopharyngeal Carcinoma Cancer Res., September 15, 2005; 65(18): 8125 - 8133. [Abstract] [Full Text] [PDF]

				R. L. Auer, C. Jones, R. A. Mullenbach, D. Syndercombe-Court, D. W. Milligan, C. D. Fegan, and F. E. Cotter Role for CCG-trinucleotide repeats in the pathogenesis of chronic lymphocytic leukemia Blood, January 15, 2001; 97(2): 509 - 515. [Abstract] [Full Text] [PDF]

				H. A. Pulido, M. J. Fakruddin, A. Chatterjee, E. D. Esplin, N. Beleño, G. Martínez, H. Posso, G. A. Evans, and V. V. V. S. Murty Identification of a 6-cM Minimal Deletion at 11q23.1-23.2 and Exclusion of PPP2R1B Gene as a Deletion Target in Cervical Cancer Cancer Res., December 1, 2000; 60(23): 6677 - 6682. [Abstract] [Full Text]

				A. S. C. Chan, K. F. To, K. W. Lo, K. F. Mak, W. Pak, B. Chiu, G. M. K. Tse, M. Ding, X. Li, J. C. K. Lee, et al. High Frequency of Chromosome 3p Deletion in Histologically Normal Nasopharyngeal Epithelia from Southern Chinese Cancer Res., October 1, 2000; 60(19): 5365 - 5370. [Abstract] [Full Text]

				K.-W. Lo, P. M. L. Teo, A. B.-Y. Hui, K.-F. To, Y.-S. Tsang, S. Y.-Y. Chan, K.-F. Mak, J. C. K. Lee, and D. P. Huang High Resolution Allelotype of Microdissected Primary Nasopharyngeal Carcinoma Cancer Res., July 1, 2000; 60(13): 3348 - 3353. [Abstract] [Full Text]

				K. C. Connolly, H. Gabra, C. J. Millwater, K. J. Taylor, G. J. Rabiasz, J. E. V. Watson, J. F. Smyth, A. H. Wyllie, and D. I. Jodrell Identification of a Region of Frequent Loss of Heterozygosity at 11q24 in Colorectal Cancer Cancer Res., June 1, 1999; 59(12): 2806 - 2809. [Abstract] [Full Text] [PDF]

				Y. Murakami, T. Nobukuni, K. Tamura, T. Maruyama, T. Sekiya, Y. Arai, H. Gomyou, A. Tanigami, M. Ohki, D. Cabin, et al. Localization of tumor suppressor activity important in nonsmall cell lung carcinoma on chromosome 11q PNAS, July 7, 1998; 95(14): 8153 - 8158. [Abstract] [Full Text] [PDF]

				J.-Y. Ko, L. T. Lui, T.-S. Sheen, P.-J. Lou, and M.-M. Hsu Increased Mutagen Sensitivity in Patients With Head and Neck Cancer Is Less Pronounced in Patients With Nasopharyngeal Carcinoma Arch Otolaryngol Head Neck Surg, May 1, 1998; 124(5): 578 - 581. [Abstract] [Full Text] [PDF]