| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Institute for Molecular Virology, St. Louis University Health Sciences Center, St. Louis, Missouri 63110
The bcl-2 family of genes code for proteins that contain anti-apoptotic or pro-apoptotic activity. The human bfl-1 gene contains an open reading frame for a 175-amino acid Bcl-2 family protein. Among the various Bcl-2 family members, the Bfl-1 protein shares the highest homology with the mouse A1 protein. These two proteins share three conserved domains, Bcl homology (BH)1, BH2, and BH3, with other Bcl-2 family proteins. Unlike other Bcl-2 family members, Bfl-1 contains a Gln-rich NH2-terminal region and lacks an NH (19K homology) domain 1. We demonstrate that the Bfl-1 protein suppresses apoptosis induced by the p53 tumor suppressor protein in a manner similar to other Bcl-2 family members such as Bcl-2, Bcl-XL and EBV-BHRF1. In addition, the bfl-1 gene cooperates efficiently with the Ela oncogene in transformation of primary rodent epithelial cells. Our results suggest that the human bfl-1 gene may play an important role in carcinogenesis.
1 This research was supported by Grants CA-33616 and CA-31719 from the National Cancer Institute.
2 C. D-E. and T. S. contributed equally to this work.
3 To whom requests for reprints should be addressed, at Saint Louis University School of Medicine, Health Sciences Center, 3681 Park Ave., St. Louis, MO 63110-2592. Phone: (314) 577-8416; Fax: (314) 577-8406.
Received 5/28/96. Accepted 7/17/96.
This article has been cited by other articles:
|
|
 |
|
  P. M. Pegman, S. M. Smith, B. N. D'Souza, S. T. Loughran, S. Maier, B. Kempkes, P. A. Cahill, M. J. Simmons, C. Gelinas, and D. Walls Epstein-Barr Virus Nuclear Antigen 2 trans-Activates the Cellular Antiapoptotic bfl-1 Gene by a CBF1/RBPJ{kappa}-Dependent Pathway. J. Virol., August 1, 2006; 80(16): 8133 - 8144. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Thangaraju, M. Rudelius, B. Bierie, M. Raffeld, S. Sharan, L. Hennighausen, A-M. Huang, and E. Sterneck C/EBP{delta} is a crucial regulator of pro-apoptotic gene expression during mammary gland involution Development, November 1, 2005; 132(21): 4675 - 4685. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Tatetsu, Y. Okuno, M. Nakamura, F. Matsuno, T. Sonoki, I. Taniguchi, S. Uneda, K. Umezawa, H. Mitsuya, and H. Hata Dehydroxymethylepoxyquinomicin, a novel nuclear factor-{kappa}B inhibitor, induces apoptosis in multiple myeloma cells in an I{kappa}B{alpha}-independent manner Mol. Cancer Ther., July 1, 2005; 4(7): 1114 - 1120. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Zhang, J. L. Mott, S.-W. Chang, M. Stevens, P. Mikolajczak, and H. P. Zassenhaus Mitochondrial DNA mutations activate programmed cell survival in the mouse heart Am J Physiol Heart Circ Physiol, May 1, 2005; 288(5): H2476 - H2483. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. B. Geigl, S. Langer, S. Barwisch, K. Pfleghaar, G. Lederer, and M. R. Speicher Analysis of Gene Expression Patterns and Chromosomal Changes Associated with Aging Cancer Res., December 1, 2004; 64(23): 8550 - 8557. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. N. D'Souza, L. C. Edelstein, P. M. Pegman, S. M. Smith, S. T. Loughran, A. Clarke, A. Mehl, M. Rowe, C. Gelinas, and D. Walls Nuclear Factor {kappa}B-Dependent Activation of the Antiapoptotic bfl-1 Gene by the Epstein-Barr Virus Latent Membrane Protein 1 and Activated CD40 Receptor J. Virol., February 15, 2004; 78(4): 1800 - 1816. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. C. Edelstein, L. Lagos, M. Simmons, H. Tirumalai, and C. Gelinas NF-{kappa}B-Dependent Assembly of an Enhanceosome-Like Complex on the Promoter Region of Apoptosis Inhibitor Bfl-1/A1 Mol. Cell. Biol., April 15, 2003; 23(8): 2749 - 2761. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. L. Planey, A. Derfoul, A. Steplewski, N. M. Robertson, and G. Litwack Inhibition of Glucocorticoid-induced Apoptosis in 697 Pre-B Lymphocytes by the Mineralocorticoid Receptor N-terminal Domain J. Biol. Chem., October 25, 2002; 277(44): 42188 - 42196. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Sakuma, M. Yamamoto, M. Okumura, T. Kojima, T. Maruyama, and K. Yasuda High glucose inhibits apoptosis in human coronary artery smooth muscle cells by increasing bcl-xL and bfl-1/A1 Am J Physiol Cell Physiol, August 1, 2002; 283(2): C422 - C428. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Jing, L. Xia, and S. Waxman Targeted removal of PML-RARalpha protein is required prior to inhibition of histone deacetylase for overcoming all-trans retinoic acid differentiation resistance in acute promyelocytic leukemia Blood, July 18, 2002; 100(3): 1008 - 1013. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. B. Werner, E. de Vries, S. W. G. Tait, I. Bontjer, and J. Borst Bcl-2 Family Member Bfl-1/A1 Sequesters Truncated Bid to Inhibit Its Collaboration with Pro-apoptotic Bak or Bax J. Biol. Chem., June 14, 2002; 277(25): 22781 - 22788. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Nieborowska-Skorska, G. Hoser, P. Kossev, M. A. Wasik, and T. Skorski Complementary functions of the antiapoptotic protein A1 and serine/threonine kinase pim-1 in the BCR/ABL-mediated leukemogenesis Blood, May 29, 2002; 99(12): 4531 - 4539. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. V. Capuco, M. Li, E. Long, S. Ren, K. S. Hruska, K. Schorr, and P. A. Furth Concurrent Pregnancy Retards Mammary Involution: Effects on Apoptosis and Proliferation of the Mammary Epithelium after Forced Weaning of Mice Biol Reprod, May 1, 2002; 66(5): 1471 - 1476. [Abstract] [Full Text]
|
|
|
|
|
|
S. Ha, S. Lee, M. Chung, and Y. Choi Mouse ING1 Homologue, a Protein Interacting with A1, Enhances Cell Death and Is Inhibited by A1 in Mammary Epithelial Cells Cancer Res., March 1, 2002; 62(5): 1275 - 1278. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Shinoda, Y. Nakamura, K. Matsushita, K. Shimoda, H. Okita, M. Fukuma, T. Yamada, H. Ohde, Y. Oguchi, J.-i. Hata, et al. Light induced apoptosis is accelerated in transgenic retina overexpressing human EAT/mcl-1, an anti-apoptotic bcl-2 related gene Br. J. Ophthalmol., October 1, 2001; 85(10): 1237 - 1243. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Jing, L. Wang, L. Xia, G.-q. Chen, Z. Chen, W. H. Miller, and S. Waxman Combined effect of all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia cells in vitro and in vivo Blood, January 1, 2001; 97(1): 264 - 269. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. D'Souza, M. Rowe, and D. Walls The bfl-1 Gene Is Transcriptionally Upregulated by the Epstein-Barr Virus LMP1, and Its Expression Promotes the Survival of a Burkitt's Lymphoma Cell Line J. Virol., July 15, 2000; 74(14): 6652 - 6658. [Abstract] [Full Text]
|
|
|
|
|
|
H. Zhang, S. W. Cowan-Jacob, M. Simonen, W. Greenhalf, J. Heim, and B. Meyhack Structural Basis of BFL-1 for Its Interaction with BAX and Its Anti-apoptotic Action in Mammalian and Yeast Cells J. Biol. Chem., April 6, 2000; 275(15): 11092 - 11099. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. L. Horn, T. D. O'Brien, L. B. Schook, and M. S. Rutherford Acute Hepatotoxicant Exposure Induces TNFR-Mediated Hepatic Injury and Cytokine/Apoptotic Gene Expression Toxicol. Sci., March 1, 2000; 54(1): 262 - 273. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-Y. Wang, D. C. Guttridge, M. W. Mayo, and A. S. Baldwin Jr. NF-kappa B Induces Expression of the Bcl-2 Homologue A1/Bfl-1 To Preferentially Suppress Chemotherapy-Induced Apoptosis Mol. Cell. Biol., September 1, 1999; 19(9): 5923 - 5929. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Nieborowska-Skorska, M. A. Wasik, A. Slupianek, P. Salomoni, T. Kitamura, B. Calabretta, and T. Skorski Signal Transducer and Activator of Transcription (STAT)5 Activation by BCR/ABL Is Dependent on Intact Src Homology (SH)3 and SH2 Domains of BCR/ABL and Is Required for Leukemogenesis J. Exp. Med., April 19, 1999; 189(8): 1229 - 1242. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W.-X. Zong, L. C. Edelstein, C. Chen, J. Bash, and C. Gélinas The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappa B that blocks TNFalpha -induced apoptosis Genes & Dev., February 15, 1999; 13(4): 382 - 387. [Abstract] [Full Text]
|
|
|
|
|
|
I. Otter, S. Conus, U. Ravn, M. Rager, R. Olivier, L. Monney, D. Fabbro, and C. Borner The Binding Properties and Biological Activities of Bcl-2 and Bax in Cells Exposed to Apoptotic Stimuli J. Biol. Chem., March 13, 1998; 273(11): 6110 - 6120. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Druilhe, M. Arock, L. Le Goff, and M. Pretolani Human Eosinophils Express Bcl-2 Family Proteins: Modulation of Mcl-1 Expression by IFN-gamma Am. J. Respir. Cell Mol. Biol., March 1, 1998; 18(3): 315 - 322. [Abstract] [Full Text]
|
|
|
|
|
|
P. J. Duriez, F. Wong, K. Dorovini-Zis, R. Shahidi, and A. Karsan A1 Functions at the Mitochondria to Delay Endothelial Apoptosis in Response to Tumor Necrosis Factor J. Biol. Chem., June 9, 2000; 275(24): 18099 - 18107. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
