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Section of Cell Biology and Experimental Pathology, Institute of Cancer Research, Haddow Laboratories, 15 Cotswold Road, Sutton, Surrey SM2 5NG [T. C. D., S. J. W-H., H. J., G. S., B. A. G.]; ICRF Molecular Oncology Laboratory, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DU [K. S., E. L. H., A. L. H.]; and University College London Medical School, Department of Surgery, Charles Bell House, 67-73 Riding House Street, London W1P 7LD [M. O.], United Kingdom
WNT-2 is a secreted polypeptide with mitogenic effects in murine mammary epithelial cells, but its role in human cancer is unknown. Using RNase protection analysis of primary cell preparations and in situ hybridization analysis, we report that WNT-2 is expressed at low levels in normal human breast fibroblasts but not in epithelial cells. WNT-2 was found to be expressed at high levels in both the epithelium and stroma of 5 of 11 infiltrating carcinomas and 2 of 6 fibroadenomas. The high level of WNT-2 expression in tumor epithelium suggests that tumorigenesis may involve the ectopic expression of WNT-2 and the creation of an autocrine Wnt signaling loop.
1 To whom requests for reprints should be addressed. Fax: 0181-643-0238; E-mail: trevor@icr.ac.uk.
Received 7/ 8/96. Accepted 8/13/96.
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