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Selective Expression of One c-myc Allele in Two Human Myeloma Cell Lines

National Cancer Institute-Navy Medical Oncology Branch, NIH. Bethesda, Maryland 20889-5105 [W. M. K., L. A. B., M. C.], and Division of Hematology/Oncology, Cornell University Medical College, New York, New York 10021 [P. L. B.]

Chromosomal translocations or DNA rearrangements affecting c-myc occur in almost all murine plasmacytoma and human Burkitt's lymphoma tumors and are associated with a high incidence of exon 2 missense mutations and selective expression of the affected allele. Screening nine multiple myeloma cell lines, we identified no exon 2 missense mutations but did identify two lines with single, silent mutations in exon 1 and exon 2, respectively. Each of these informative multiple myeloma cell lines selectively expresses only one c-myc allele despite the apparent absence of chromosomal translocations or DNA rearrangements affecting c-myc.

¹ To whom requests for reprints should be addressed, at National Cancer Institute-Navy Medical Oncology, Naval Hospital. Building 8. Room 5101, Bethesda, MD 20889-5105, Phone: (301) 496-0925; Fax: (301) 496-0047; E-mail: Michael_Kuehl@nih.gov.

Received 6/28/96. Accepted 8/16/96.

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