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Are Correlated with Neoplastic Transformation of Mammary Epithelial Cells1
Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030-3498 [B. R., A. J., D. M., J. M. R.], and Department of Biochemistry and McGill Cancer Center, Faculty of Medicine, McGill University, Montreal, Quebec H3G 1Y6, Canada [A-C. G., N. S.]
A translationally regulated, dominant-negative isoform of CCAAT/enhancer-binding protein ß is expressed in transplantable and primary mouse mammary tumors of different etiologies but is not expressed in preneoplastic mammary hyperplasias or in primary prostate, lung, lens, ovary, or lymphoid tumors. The eukaryotic initiation factor 2
protein is also expressed at significantly higher levels (69.8 ± 7.2%) in these mammary tumors compared with normal and hyperplastic tissues. Thus, misregulation of eukaryotic initiation factor 2 may promote the expression of a dominant-negative CCAAT/enhancer-binding protein ß isoform, which may inhibit terminal differentiation and facilitate uncontrolled proliferation of mammary epithelial cells.
1 This work was supported by NIH Grants CA-47112 (D. M.), CA-16303 (J. M. R.), and DK-07696 (B. R.).
2 To whom requests for reprints should be addressed, at Department of Cell Biology, Texas Medical Center, Baylor College of Medicine, Houston, TX 77030-3498. E-mail: jrosen@bcm.tmc.edu.
Received 7/19/96. Accepted 8/16/96.
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