This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ogawa, J.-i. Articles by Koide, S. Search for Related Content PubMed PubMed Citation Articles by Ogawa, J.-i. Articles by Koide, S.

Expression of -1,3-Fucosyltransferase Type IV and VII Genes Is Related to Poor Prognosis in Lung Cancer

First Department of Surgery, School of Medicine, Tokai University, Bohseidai, Isehara, Kanagawa, 259-11, Japan

To date, five -1,3-fucosyltransferase genes (Fuc-TIII, IV, V, VI, and VII) have been cloned. To examine the role of -1,3-fucosyltransferase in the synthesis of sialyl Lewis x and the prognosis of lung cancer, PCR amplification of five fucoyltransferase genes and immunohistochemical staining of sialyl Lewis x were performed in 333 patients with lung cancer who underwent surgical resection from 1980 to 1993. The frequencies of Fuc-TIII/V, Fuc-TVI, Fuc-TIV, and Fuc-TVII expression were 9%, 26%, 75%, and 66%, respectively. The frequency of sialyl Lewis x expression (75%) was comparable to Fuc-TIV and Fuc-TVII expression. However, the grading of sialyl Lewis x staining correlated only with the grading of Fuc-TVII gene amplification. Survival of the patients whose tumors showed strong expression of Fuc-TIV and/or FucT-VII was significantly shorter than that of the patients whose tumors did not express either Fuc-TIV or Fuc-TVII. These results suggest that Fuc-TIV and Fuc-TVII expression may be of prognostic value among patients with lung cancer by participating in the biosynthesis of sialyl Lewis x.

¹ To whom requests for reprints should be addressed. Phone: 463-93-1121; Fax: 463-95-7567.

Received 8/29/95. Accepted 11/ 7/95.

This article has been cited by other articles:

				S. Allahverdian, K. R. Wojcik, and D. R. Dorscheid Airway epithelial wound repair: role of carbohydrate sialyl Lewisx Am J Physiol Lung Cell Mol Physiol, October 1, 2006; 291(4): L828 - L836. [Abstract] [Full Text] [PDF]

				Y. I. Kawamura, R. Kawashima, R. Fukunaga, K. Hirai, N. Toyama-Sorimachi, M. Tokuhara, T. Shimizu, and T. Dohi Introduction of Sda Carbohydrate Antigen in Gastrointestinal Cancer Cells Eliminates Selectin Ligands and Inhibits Metastasis Cancer Res., July 15, 2005; 65(14): 6220 - 6227. [Abstract] [Full Text] [PDF]

				T. Koike, N. Kimura, K. Miyazaki, T. Yabuta, K. Kumamoto, S. Takenoshita, J. Chen, M. Kobayashi, M. Hosokawa, A. Taniguchi, et al. Hypoxia induces adhesion molecules on cancer cells: A missing link between Warburg effect and induction of selectin-ligand carbohydrates PNAS, May 25, 2004; 101(21): 8132 - 8137. [Abstract] [Full Text] [PDF]

				E.V. Chandrasekaran, R. Chawda, J. M. Rhodes, J. Xia, C. Piskorz, and K. L. Matta Human lung adenocarcinoma {{alpha}}1,3/4-L-fucosyltransferase displays two molecular forms, high substrate affinity for clustered sialyl LacNAc type 1 units as well as mucin core 2 sialyl LacNAc type 2 unit and novel {{alpha}}1,2-L-fucosylating activity Glycobiology, May 1, 2001; 11(5): 353 - 363. [Abstract] [Full Text] [PDF]

				J. Moldvay, P. Scheid, P. Wild, K. Nabil, J. Siat, J. Borrelly, B. Marie, G. Farré, T. Labib, G. Pottier, et al. Predictive Survival Markers in Patients with Surgically Resected Non-Small Cell Lung Carcinoma Clin. Cancer Res., March 1, 2000; 6(3): 1125 - 1134. [Abstract] [Full Text]

				Y. J. Kim, L. Borsig, H.-L. Han, N. M. Varki, and A. Varki Distinct Selectin Ligands on Colon Carcinoma Mucins Can Mediate Pathological Interactions among Platelets, Leukocytes, and Endothelium Am. J. Pathol., August 1, 1999; 155(2): 461 - 472. [Abstract] [Full Text] [PDF]

				D. A. Withers and S.-i. Hakomori Human alpha (1,3)-Fucosyltransferase IV (FUTIV) Gene Expression Is Regulated by Elk-1 in the U937 Cell Line J. Biol. Chem., December 15, 2000; 275(51): 40588 - 40593. [Abstract] [Full Text] [PDF]