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Cancer Cell Biology Program [T. M-A., X. L., R. J.] and Division of Medical Oncology and Hematology [S. A.], H. L. Moffitt Cancer Center, University of South Florida School of Medicine, Tampa, Florida 33612, and Section of Medical Oncology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520-8032 [M. R.]
Expression of transforming growth factor ß type II receptors (TßR-IIs) is either greatly decreased or absent in many tumors, implying that the loss of TßR-II function is one of the mechanisms leading to tumor development. In this report, we examine the expression of the TßR-II receptor in a squamous carcinoma cell line that expressed reduced levels of TßR-II mRNA. We found an A 
G mutation at position -364 of the 5' untranslated region of the TßR-II gene. This mutation results in significantly decreased transcriptional activity by the TßR-II gene promoter, suggesting that it is a primary mechanism of loss of TßR-II expression in this tumor cell line.
1 To whom requests for reprints should be addressed, at H. L. Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612-9497.
Received 7/22/96. Accepted 9/18/96.
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