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Genotoxicity of Human Mammary Lipid¹

Haddow Laboratories, Institute of Cancer Research, Cotswold Road, Sutton, Surrey SM2 5NG, United Kingdom

We tested the proposition that human mammary lipid contains mutagenic/genotoxic agents that could cause DNA damage in adjacent epithelial cells. Lipid samples from breast tissue surgically removed from 40 women undergoing elective reduction mammoplasty were extracted by a solid-phase procedure. Mutagenicity was observed in Salmonella typhimurium TA98 and TA1538 in 16 of 40 (40%) extracts assayed with rat-liver S9, but not in its absence. No mutagenicity was seen in S. typhimurium TA100 or Escherichia coli WP2uvrA(pKM101). Bacterial mutagenicity correlated with micronucleus-forming activity in a metabolically competent mammalian cell line (MCL-5). This genotoxic activity merits further investigation in relation to the etiology of breast cancer.

¹ Supported by a research grant from the Association for International Cancer Research.

² To whom requests for reprints should be addressed. Phone: 44-181-643-8901, Extension 4646; Fax: 44-181-770-7290; E-mail: FLMartin@icr.ac.uk.

Received 9/16/96. Accepted 10/24/96.

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