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[Cancer Research 56, 448-451, February 1, 1996]
© 1996 American Association for Cancer Research
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A New Member of the Proprotein Convertase Gene Family (LPC) Is Located at a Chromosome Translocation Breakpoint in Lymphomas

Joanne Meerabux, Marie-Laure Yaspo, Anton J. Roebroek, Wim J. M. Van de Ven, T. Andrew Lister and Bryan D. Young1

Department of Medical Oncology, Imperial Cancer Research Fund, St. Bartholomew's Hospital, London EC1M 6BQ, United Kingdom [J. M., T. A. L., B. D. Y.]; Genome Analysis Laboratory, Imperial Cancer Research Fund. Lincoln's Inn Fields, London, United Kingdom [M-L. Y.]; and Laboratory of Molecular Oncology, Center for Human Genetics, University of Leuven, B3000 Leuven, Belgium [A. J. R., W. J. M. V. d. V.]

A new member of the proprotein convertase gene family (LPC) has been identified at a chromosome translocation breakpoint occurring in a high grade lymphoma. The translocation t(11;14)(q23;q32) has been molecularly cloned and shown to be the result of a fusion between an intron in the 3'-untranslated region of LPC with a sequence close to the switch region S{gamma}4 of the IGH locus. The LPC gene encodes a protein of 785 amino acids with substantial homology to furin and the other members of the proprotein convertase family and represents a novel target for chromosome translocation and subsequent deregulation.

1 To whom requests for reprints should be addressed.

Received 10/13/95. Accepted 12/11/95.




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HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 1996 by the American Association for Cancer Research.