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[Cancer Research 56, 467-470, February 1, 1996]
© 1996 American Association for Cancer Research
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Interleukin 12 Potentiates the Curative Effect of a Vaccine Based on Interleukin 2-transduced Tumor Cells1

Maddalena Vagliani, Monica Rodolfo, Federica Cavallo, Mariella Parenza, Cecilia Melani, Giorgio Parmiani, Guido Forni and Mario P. Colombo2

Experimental Oncology D. Istituto Nazionale Tumori, Via Venezian 1, 20133 Milan [M. V., M. R., M. P., C. M., G. P., M. P. C.], and Consiglio Nazionale delle Ricerche-Centro Istocompatibilitá e Oncologia Sperimentale, Via Santena 19, 10126 Turin [F. C., G. F.], Italy

The purpose of these studies was to determine whether systemic administration of recombinant interleukin 12 (rIL-12) is able to potentiate an initial, but insufficient T-cell antitumor response. Mice challenged with carcinoma cells engineered to release interleukin 2 (IL-2) and displaying such a response received single or multiple i.p. injections of rIL-12. This combination of systemic rIL-12 and local IL-2 increased the percentage of mice that rejected two different IL-2 gene-transduced tumors. In another set of experiments more closely resembling a clinical situation, IL-2 gene-transduced tumors were used as vaccines in an attempt to cure mice bearing wild-type parental tumors. The combination of these vaccines with systemic rIL-12 cured mice more effectively than rIL-12 and IL-2 gene-transduced tumor vaccines alone.

1 This work was supported by the Italian Association for Cancer Research (AIRC) Special Program on Gene Therapy and by grants from Consiglio Nazionale delle Ricerche Target Project ACRO.

2 To whom requests for reprints should be addressed. Phone: (+39) 2-2390252; Fax: (+39) 2-2362692.

Received 11/ 3/95. Accepted 12/13/95.




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HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 1996 by the American Association for Cancer Research.