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Departments of Radiation Oncology [D. M., B., J. M. B., L. R. P., M. W. D.] and Pathology [L. J. L.] and Division of Orthopedics, Department of Surgery [S. P. S., J. M. H.], Duke University Comprehensive Cancer Center, Durham, North Carolina 27710
This study was performed to explore the relationship between tumor oxygenation and treatment outcome in human soft tissue sarcoma. Twenty-two patients with nonmetastatic, high-grade, soft tissue sarcomas underwent preoperative irradiation and hyperthermia and pretreatment measurement of tumor oxygenation. The 18-month actuarial disease-free survival was 70% for patients with tumor median oxygen pressure (pO2) values of >10 mm Hg but only 35% for those with median pO2 values of < 10 mm Hg (P = 0.01). There were eight treatment failures; the first site of recurrence was lung in all patients. Median pO2 was 7.5 mm Hg for metastasizing tumors versus 20 mm Hg for nonmetastasizing tumors (P = 0.03). Potential mechanisms and implications for clinical trial design are discussed.
1 This work was supported by NIH Grant CA42745.
2 To whom requests for reprints should be addressed, at Department of Radiation Oncology, Box 3085, Duke University Medical Center, Durham, NC 27710. Phone: (919) 660-2119; Fax: (919) 684-3953; E-mail: brizel@radonc.duke.edu.
Received 12/ 1/95. Accepted 1/17/96.
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