Cancer Research Infection and Cancer: Biology, Therapeutics, and Prevention
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online

[Cancer Research 56, 941-943, March 1, 1996]
© 1996 American Association for Cancer Research

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Brizel, D. M.
Right arrow Articles by Dewhirst, M. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brizel, D. M.
Right arrow Articles by Dewhirst, M. W.

Tumor Oxygenation Predicts for the Likelihood of Distant Metastases in Human Soft Tissue Sarcoma1

David M. Brizel2, Sean P. Scully, John M. Harrelson, Lester J. Layfield, Joseph M. Bean, Leonard R. Prosnitz and Mark W. Dewhirst

Departments of Radiation Oncology [D. M., B., J. M. B., L. R. P., M. W. D.] and Pathology [L. J. L.] and Division of Orthopedics, Department of Surgery [S. P. S., J. M. H.], Duke University Comprehensive Cancer Center, Durham, North Carolina 27710

This study was performed to explore the relationship between tumor oxygenation and treatment outcome in human soft tissue sarcoma. Twenty-two patients with nonmetastatic, high-grade, soft tissue sarcomas underwent preoperative irradiation and hyperthermia and pretreatment measurement of tumor oxygenation. The 18-month actuarial disease-free survival was 70% for patients with tumor median oxygen pressure (pO2) values of >10 mm Hg but only 35% for those with median pO2 values of < 10 mm Hg (P = 0.01). There were eight treatment failures; the first site of recurrence was lung in all patients. Median pO2 was 7.5 mm Hg for metastasizing tumors versus 20 mm Hg for nonmetastasizing tumors (P = 0.03). Potential mechanisms and implications for clinical trial design are discussed.

1 This work was supported by NIH Grant CA42745.

2 To whom requests for reprints should be addressed, at Department of Radiation Oncology, Box 3085, Duke University Medical Center, Durham, NC 27710. Phone: (919) 660-2119; Fax: (919) 684-3953; E-mail: brizel@radonc.duke.edu.

Received 12/ 1/95. Accepted 1/17/96.




This article has been cited by other articles:


Home page
Cancer Res.Home page
Y. Monnier, P. Farmer, G. Bieler, N. Imaizumi, T. Sengstag, G. C. Alghisi, J.-C. Stehle, L. Ciarloni, S. Andrejevic-Blant, R. Moeckli, et al.
CYR61 and {alpha}V{beta}5 Integrin Cooperate to Promote Invasion and Metastasis of Tumors Growing in Preirradiated Stroma
Cancer Res., September 15, 2008; 68(18): 7323 - 7331.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
A. Mayer, M. Hockel, A. Wree, C. Leo, L.-C. Horn, and P. Vaupel
Lack of Hypoxic Response in Uterine Leiomyomas despite Severe Tissue Hypoxia
Cancer Res., June 15, 2008; 68(12): 4719 - 4726.
[Abstract] [Full Text] [PDF]


Home page
JNMHome page
K. A. Krohn, J. M. Link, and R. P. Mason
Molecular Imaging of Hypoxia
J. Nucl. Med., June 1, 2008; 49(Suppl_2): 129S - 148S.
[Abstract] [Full Text] [PDF]


Home page
aacredbookHome page
W. R Wilson, K. O Hicks, F. B Pruijn, and A. V Patterson
Targeting Tumor Hypoxia with Prodrugs: Challenges and Opportunities
Am. Assoc. Cancer Res. Educ. Book, April 12, 2008; 2008(1): 293 - 310.
[Abstract] [Full Text] [PDF]


Home page
JNMHome page
F. Dehdashti, P. W. Grigsby, J. S. Lewis, R. Laforest, B. A. Siegel, and M. J. Welch
Assessing Tumor Hypoxia in Cervical Cancer by PET with 60Cu-Labeled Diacetyl-Bis(N4-Methylthiosemicarbazone)
J. Nucl. Med., February 1, 2008; 49(2): 201 - 205.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
K. Glunde, T. Shah, P. T. Winnard Jr., V. Raman, T. Takagi, F. Vesuna, D. Artemov, and Z. M. Bhujwalla
Hypoxia Regulates Choline Kinase Expression through Hypoxia-Inducible Factor-1{alpha} Signaling in a Human Prostate Cancer Model
Cancer Res., January 1, 2008; 68(1): 172 - 180.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
S.-Y. Park, X. Yu, C. Ip, J. L. Mohler, P. N. Bogner, and Y.-M. Park
Peroxiredoxin 1 Interacts with Androgen Receptor and Enhances Its Transactivation
Cancer Res., October 1, 2007; 67(19): 9294 - 9303.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
E. Piovan, V. Tosello, S. Indraccolo, M. Masiero, L. Persano, G. Esposito, R. Zamarchi, M. Ponzoni, L. Chieco-Bianchi, R. Dalla-Favera, et al.
Differential Regulation of Hypoxia-Induced CXCR4 Triggering during B-Cell Development and Lymphomagenesis
Cancer Res., September 15, 2007; 67(18): 8605 - 8614.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
A. V. Patterson, D. M. Ferry, S. J. Edmunds, Y. Gu, R. S. Singleton, K. Patel, S. M. Pullen, K. O. Hicks, S. P. Syddall, G. J. Atwell, et al.
Mechanism of Action and Preclinical Antitumor Activity of the Novel Hypoxia-Activated DNA Cross-Linking Agent PR-104
Clin. Cancer Res., July 1, 2007; 13(13): 3922 - 3932.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
D. Procissi, F. Claus, P. Burgman, J. Koziorowski, J. D. Chapman, S. B. Thakur, C. Matei, C. C. Ling, and J. A. Koutcher
In vivo 19F Magnetic Resonance Spectroscopy and Chemical Shift Imaging of Tri-Fluoro-Nitroimidazole as a Potential Hypoxia Reporter in Solid Tumors
Clin. Cancer Res., June 15, 2007; 13(12): 3738 - 3747.
[Abstract] [Full Text] [PDF]


Home page
The OncologistHome page
A. Wouters, B. Pauwels, F. Lardon, and J. B. Vermorken
Review: Implications of In Vitro Research on the Effect of Radiotherapy and Chemotherapy Under Hypoxic Conditions
Oncologist, June 1, 2007; 12(6): 690 - 712.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
R. A. Cairns, I. Papandreou, P. D. Sutphin, and N. C. Denko
Metabolic targeting of hypoxia and HIF1 in solid tumors can enhance cytotoxic chemotherapy
PNAS, May 29, 2007; 104(22): 9445 - 9450.
[Abstract] [Full Text] [PDF]


Home page
Biophys. JHome page
A. Bratasz, A. C. Kulkarni, and P. Kuppusamy
A Highly Sensitive Biocompatible Spin Probe for Imaging of Oxygen Concentration in Tissues
Biophys. J., April 15, 2007; 92(8): 2918 - 2925.
[Abstract] [Full Text] [PDF]


Home page
The OncologistHome page
S. Senan and E. F. Smit
Design of Clinical Trials of Radiation Combined with Antiangiogenic Therapy
Oncologist, April 1, 2007; 12(4): 465 - 477.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
E. K. Rofstad, K. Galappathi, B. Mathiesen, and E.-B. M. Ruud
Fluctuating and Diffusion-Limited Hypoxia in Hypoxia-Induced Metastasis
Clin. Cancer Res., April 1, 2007; 13(7): 1971 - 1978.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
C. Leo, L.-C. Horn, C. Rauscher, B. Hentschel, C. E. Richter, A. Schutz, C. P. Leo, and M. Hockel
Lack of Apoptotic Protease Activating Factor-1 Expression and Resistance to Hypoxia-Induced Apoptosis in Cervical Cancer
Clin. Cancer Res., February 15, 2007; 13(4): 1149 - 1153.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
C. Leo, L.-C. Horn, C. Rauscher, B. Hentschel, A. Liebmann, G. Hildebrandt, and M. Hockel
Expression of Erythropoietin and Erythropoietin Receptor in Cervical Cancer and Relationship to Survival, Hypoxia, and Apoptosis
Clin. Cancer Res., December 1, 2006; 12(23): 6894 - 6900.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
D. J. Brennan, K. Jirstrom, A. Kronblad, R. C. Millikan, G. Landberg, M. J. Duffy, L. Ryden, W. M. Gallagher, and S. L. O'Brien
CA IX is an Independent Prognostic Marker in Premenopausal Breast Cancer Patients with One to Three Positive Lymph Nodes and a Putative Marker of Radiation Resistance.
Clin. Cancer Res., November 1, 2006; 12(21): 6421 - 6431.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
V. Raman, D. Artemov, A. P. Pathak, P. T. Winnard Jr., S. McNutt, A. Yudina, A. Bogdanov Jr., and Z. M. Bhujwalla
Characterizing Vascular Parameters in Hypoxic Regions: A Combined Magnetic Resonance and Optical Imaging Study of a Human Prostate Cancer Model.
Cancer Res., October 15, 2006; 66(20): 9929 - 9936.
[Abstract] [Full Text] [PDF]


Home page
Br. J. Radiol.Home page
A Y Isa, T H Ward, C M L West, N J Slevin, and J J Homer
Hypoxia in head and neck cancer
Br. J. Radiol., October 1, 2006; 79(946): 791 - 798.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
I. Serganova, J. Humm, C. Ling, and R. Blasberg
Tumor hypoxia imaging.
Clin. Cancer Res., September 15, 2006; 12(18): 5260 - 5264.
[Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
S.-B. Catrina, I. R. Botusan, A. Rantanen, A. I. Catrina, P. Pyakurel, O. Savu, M. Axelson, P. Biberfeld, L. Poellinger, and K. Brismar
Hypoxia-Inducible Factor-1{alpha} and Hypoxia-Inducible Factor-2{alpha} Are Expressed in Kaposi Sarcoma and Modulated by Insulin-like Growth Factor-I
Clin. Cancer Res., August 1, 2006; 12(15): 4506 - 4514.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
M. Elas, K.-H. Ahn, A. Parasca, E. D. Barth, D. Lee, C. Haney, and H. J. Halpern
Electron paramagnetic resonance oxygen images correlate spatially and quantitatively with oxylite oxygen measurements.
Clin. Cancer Res., July 15, 2006; 12(14): 4209 - 4217.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
E. K. Rofstad, B. Mathiesen, K. Kindem, and K. Galappathi
Acidic Extracellular pH Promotes Experimental Metastasis of Human Melanoma Cells in Athymic Nude Mice.
Cancer Res., July 1, 2006; 66(13): 6699 - 6707.
[Abstract] [Full Text] [PDF]


Home page
JCOHome page
D. M. Brizel and R. Esclamado
Concurrent Chemoradiotherapy for Locally Advanced, Nonmetastatic, Squamous Carcinoma of the Head and Neck: Consensus, Controversy, and Conundrum
J. Clin. Oncol., June 10, 2006; 24(17): 2612 - 2617.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
Q.-T. Le, E. Chen, A. Salim, H. Cao, C. S. Kong, R. Whyte, J. Donington, W. Cannon, H. Wakelee, R. Tibshirani, et al.
An Evaluation of Tumor Oxygenation and Gene Expression in Patients with Early Stage Non-Small Cell Lung Cancers
Clin. Cancer Res., March 1, 2006; 12(5): 1507 - 1514.
[Abstract] [Full Text] [PDF]


Home page
J. Physiol.Home page
N. Tajima, K. Schonherr, S. Niedling, M. Kaatz, H. Kanno, R. Schonherr, and S. H. Heinemann
Ca2+-activated K+ channels in human melanoma cells are up-regulated by hypoxia involving hypoxia-inducible factor-1{alpha} and the von Hippel-Lindau protein
J. Physiol., March 1, 2006; 571(2): 349 - 359.
[Abstract] [Full Text] [PDF]


Home page
Mol Cancer ResHome page
R. Cairns, I. Papandreou, and N. Denko
Overcoming Physiologic Barriers to Cancer Treatment by Molecularly Targeting the Tumor Microenvironment
Mol. Cancer Res., February 1, 2006; 4(2): 61 - 70.
[Abstract] [Full Text] [PDF]


Home page
Ann. Surg. Oncol.Home page
M. Reinblatt, R. H. Pin, W. J. Bowers, H. J. Federoff, and Y. Fong
Herpes Simplex Virus Amplicon Delivery of a Hypoxia-Inducible Soluble Vascular Endothelial Growth Factor Receptor (sFlk-1) Inhibits Angiogenesis and Tumor Growth in Pancreatic Adenocarcinoma
Ann. Surg. Oncol., December 1, 2005; 12(12): 1025 - 1036.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
R. D. Lester, M. Jo, W. M. Campana, and S. L. Gonias
Erythropoietin Promotes MCF-7 Breast Cancer Cell Migration by an ERK/Mitogen-activated Protein Kinase-dependent Pathway and Is Primarily Responsible for the Increase in Migration Observed in Hypoxia
J. Biol. Chem., November 25, 2005; 280(47): 39273 - 39277.
[Abstract] [Full Text] [PDF]


Home page
Mol Cancer ResHome page
D. E. Feldman, V. Chauhan, and A. C. Koong
The Unfolded Protein Response: A Novel Component of the Hypoxic Stress Response in Tumors
Mol. Cancer Res., November 1, 2005; 3(11): 597 - 605.
[Abstract] [Full Text] [PDF]


Home page
JCOHome page
M. Hedenus, J. Vansteenkiste, D. Kotasek, M. Austin, and R. G. Amado
Darbepoetin Alfa for the Treatment of Chemotherapy-Induced Anemia: Disease Progression and Survival Analysis From Four Randomized, Double-Blind, Placebo-Controlled Trials
J. Clin. Oncol., October 1, 2005; 23(28): 6941 - 6948.
[Abstract] [Full Text] [PDF]


Home page
Drug Metab. Dispos.Home page
P. Parte and D. Kupfer
OXIDATION OF TAMOXIFEN BY HUMAN FLAVIN-CONTAINING MONOOXYGENASE (FMO) 1 AND FMO3 TO TAMOXIFEN-N-OXIDE AND ITS NOVEL REDUCTION BACK TO TAMOXIFEN BY HUMAN CYTOCHROMES P450 AND HEMOGLOBIN
Drug Metab. Dispos., October 1, 2005; 33(10): 1446 - 1452.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
V. Cristini, H. B. Frieboes, R. Gatenby, S. Caserta, M. Ferrari, and J. Sinek
Morphologic Instability and Cancer Invasion
Clin. Cancer Res., October 1, 2005; 11(19): 6772 - 6779.
[Abstract] [Full Text] [PDF]


Home page
Drug Metab. Dispos.Home page
D. S. Riddick, C. Lee, S. Ramji, E. C. Chinje, R. L. Cowen, K. J. Williams, A. V. Patterson, I. J. Stratford, C. S. Morrow, A. J. Townsend, et al.
CANCER CHEMOTHERAPY AND DRUG METABOLISM
Drug Metab. Dispos., August 1, 2005; 33(8): 1083 - 1096.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
D. W. Nelson, H. Cao, Y. Zhu, B. Sunar-Reeder, C. Y.H. Choi, J. D. Faix, J. M. Brown, A. C. Koong, A. J. Giaccia, and Q.-T. Le
A Noninvasive Approach for Assessing Tumor Hypoxia in Xenografts: Developing a Urinary Marker for Hypoxia
Cancer Res., July 15, 2005; 65(14): 6151 - 6158.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
S. J. Lunt, B. A. Telfer, R. J. Fitzmaurice, I. J. Stratford, and K. J. Williams
Tirapazamine Administered as a Neoadjuvant to Radiotherapy Reduces Metastatic Dissemination
Clin. Cancer Res., June 1, 2005; 11(11): 4212 - 4216.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Respir. Crit. Care Med.Home page
M. P. L. Bard, A. Amelink, V. N. Hegt, W. J. Graveland, H. J. C. M. Sterenborg, H. C. Hoogsteden, and J. G. J. V. Aerts
Measurement of Hypoxia-related Parameters in Bronchial Mucosa by Use of Optical Spectroscopy
Am. J. Respir. Crit. Care Med., May 15, 2005; 171(10): 1178 - 1184.
[Abstract] [Full Text] [PDF]


Home page
CVIHome page
J. L. Formento, E. Berra, B. Ferrua, N. Magne, G. Simos, C. Brahimi-Horn, J. Pouyssegur, and G. Milano
Enzyme-Linked Immunosorbent Assay for Pharmacological Studies Targeting Hypoxia-Inducible Factor 1{alpha}
Clin. Vaccine Immunol., May 1, 2005; 12(5): 660 - 664.
[Abstract] [Full Text] [PDF]


Home page
J. Appl. Physiol.Home page
L. S. Ziemer, W. M. F. Lee, S. A. Vinogradov, C. Sehgal, and D. F. Wilson
Oxygen distribution in murine tumors: characterization using oxygen-dependent quenching of phosphorescence
J Appl Physiol, April 1, 2005; 98(4): 1503 - 1510.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
E. K. Rofstad, B. Mathiesen, K. Henriksen, K. Kindem, and K. Galappathi
The Tumor Bed Effect: Increased Metastatic Dissemination from Hypoxia-Induced Up-regulation of Metastasis-Promoting Gene Products
Cancer Res., March 15, 2005; 65(6): 2387 - 2396.
[Abstract] [Full Text] [PDF]


Home page
JNMHome page
S.-M. Eschmann, F. Paulsen, M. Reimold, H. Dittmann, S. Welz, G. Reischl, H.-J. Machulla, and R. Bares
Prognostic Impact of Hypoxia Imaging with 18F-Misonidazole PET in Non-Small Cell Lung Cancer and Head and Neck Cancer Before Radiotherapy
J. Nucl. Med., February 1, 2005; 46(2): 253 - 260.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
S. Ning, C. Hartley, G. Molineux, and S. J. Knox
Darbepoietin Alfa Potentiates the Efficacy of Radiation Therapy in Mice with Corrected or Uncorrected Anemia
Cancer Res., January 1, 2005; 65(1): 284 - 290.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
I. J. Hoogsteen, H. A.M. Marres, K. I.E.M. Wijffels, P. F.J.W. Rijken, J. P.W. Peters, F. J.A. van den Hoogen, E. Oosterwijk, A. J. van der Kogel, and J. H.A.M. Kaanders
Colocalization of Carbonic Anhydrase 9 Expression and Cell Proliferation in Human Head and Neck Squamous Cell Carcinoma
Clin. Cancer Res., January 1, 2005; 11(1): 97 - 106.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
S. M. Evans, K. D. Judy, I. Dunphy, W. T. Jenkins, W.-T. Hwang, P. T. Nelson, R. A. Lustig, K. Jenkins, D. P. Magarelli, S. M. Hahn, et al.
Hypoxia Is Important in the Biology and Aggression of Human Glial Brain Tumors
Clin. Cancer Res., December 15, 2004; 10(24): 8177 - 8184.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
G. J. Hutchison, H. R. Valentine, J. A. Loncaster, S. E. Davidson, R. D. Hunter, S. A. Roberts, A. L. Harris, I. J. Stratford, P. M. Price, and C. M. L. West
Hypoxia-Inducible Factor 1{alpha} Expression as an Intrinsic Marker of Hypoxia: Correlation with Tumor Oxygen, Pimonidazole Measurements, and Outcome in Locally Advanced Carcinoma of the Cervix
Clin. Cancer Res., December 15, 2004; 10(24): 8405 - 8412.
[Abstract] [Full Text] [PDF]


Home page
CarcinogenesisHome page
A. H. Box and D. J. Demetrick
Cell cycle kinase inhibitor expression and hypoxia-induced cell cycle arrest in human cancer cell lines
Carcinogenesis, December 1, 2004; 25(12): 2325 - 2335.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
X. Zhang, T. Kon, H. Wang, F. Li, Q. Huang, Z. N. Rabbani, J. P. Kirkpatrick, Z. Vujaskovic, M. W. Dewhirst, and C.-Y. Li
Enhancement of Hypoxia-Induced Tumor Cell Death In vitro and Radiation Therapy In vivo by Use of Small Interfering RNA Targeted to Hypoxia-Inducible Factor-1{alpha}
Cancer Res., November 15, 2004; 64(22): 8139 - 8142.
[Abstract] [Full Text] [PDF]


Home page
The OncologistHome page
L. Harrison and K. Blackwell
Hypoxia and Anemia: Factors in Decreased Sensitivity to Radiation Therapy and Chemotherapy?
Oncologist, November 1, 2004; 9(suppl_5): 31 - 40.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
Y. Chen, G. Shi, W. Xia, C. Kong, S. Zhao, A. F. Gaw, E. Y. Chen, G. P. Yang, A. J. Giaccia, Q.-T. Le, et al.
Identification of Hypoxia-Regulated Proteins in Head and Neck Cancer by Proteomic and Tissue Array Profiling
Cancer Res., October 15, 2004; 64(20): 7302 - 7310.
[Abstract] [Full Text] [PDF]


Home page
J EndocrinolHome page
M. Hayashi, M. Sakata, T. Takeda, T. Yamamoto, Y. Okamoto, K. Sawada, A. Kimura, R. Minekawa, M. Tahara, K. Tasaka, et al.
Induction of glucose transporter 1 expression through hypoxia-inducible factor 1{alpha} under hypoxic conditions in trophoblast-derived cells
J. Endocrinol., October 1, 2004; 183(1): 145 - 154.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
T. Lofstedt, A. Jogi, M. Sigvardsson, K. Gradin, L. Poellinger, S. Pahlman, and H. Axelson
Induction of ID2 Expression by Hypoxia-inducible Factor-1: A ROLE IN DEDIFFERENTIATION OF HYPOXIC NEUROBLASTOMA CELLS
J. Biol. Chem., September 17, 2004; 279(38): 39223 - 39231.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
Q.-T. Le, J. McCoy, S. Williamson, J. Ryu, L. E. Gaspar, M. J. Edelman, S. R. Dakhil, S. D. Sides, J. J. Crowley, and D. R. Gandara
Phase I Study of Tirapazamine Plus Cisplatin/Etoposide and Concurrent Thoracic Radiotherapy in Limited-Stage Small Cell Lung Cancer (S0004): A Southwest Oncology Group Study
Clin. Cancer Res., August 15, 2004; 10(16): 5418 - 5424.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
J. Okami, D. M. Simeone, and C. D. Logsdon
Silencing of the Hypoxia-Inducible Cell Death Protein BNIP3 in Pancreatic Cancer
Cancer Res., August 1, 2004; 64(15): 5338 - 5346.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
E. L. Jones, L. R. Prosnitz, M. W. Dewhirst, P. K. Marcom, P. H. Hardenbergh, L. B. Marks, D. M. Brizel, and Z. Vujaskovic
Thermochemoradiotherapy Improves Oxygenation in Locally Advanced Breast Cancer
Clin. Cancer Res., July 1, 2004; 10(13): 4287 - 4293.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
K. Maseide, R. A. Kandel, R. S. Bell, C. N. Catton, B. O'Sullivan, J. S. Wunder, M. Pintilie, D. Hedley, and R. P. Hill
Carbonic Anhydrase IX as a Marker for Poor Prognosis in Soft Tissue Sarcoma
Clin. Cancer Res., July 1, 2004; 10(13): 4464 - 4471.
[Abstract] [Full Text] [PDF]


Home page
Evid Based Complement Alternat MedHome page
B. Clavo, J. L. Perez, L. Lopez, G. Suarez, M. Lloret, V. Rodriguez, D. Macias, M. Santana, M. A. Hernandez, R. Martin-Oliva, et al.
Ozone Therapy for Tumor Oxygenation: a Pilot Study
Evid. Based Complement. Altern. Med., June 1, 2004; 1(1): 93 - 98.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
G. Hopfl, O. Ogunshola, and M. Gassmann
HIFs and tumors--causes and consequences
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2004; 286(4): R608 - R623.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
R. A. Cairns and R. P. Hill
Acute Hypoxia Enhances Spontaneous Lymph Node Metastasis in an Orthotopic Murine Model of Human Cervical Carcinoma
Cancer Res., March 15, 2004; 64(6): 2054 - 2061.
[Abstract] [Full Text] [PDF]