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Department of Biochemistry and Molecular Biology [D. R. F. H., J. R. L.]. Department of Pathology, The Gade Institute [L. A. A.], and Department of Surgery [J. E. V.], University of Bergen, Årstadveien 19, N-5009 Bergen, Norway
c-erbB-3 and c-erbB-4 protein expression was analyzed using immunohistochemistry in 138 fresh-frozen thyroid tissue samples from 106 patients, including 56 cases of papillary thyroid carcinoma. Increased expression of c-erbB-3 and c-erbB-4 proteins was observed in papillary carcinomas compared to nonneoplastic thyroid tissue. No amplifications of the c-erbB-3 and c-erbB-4 genes were detected. Coexisting overexpression of epidermal growth factor receptor, c-erbB-2, c-erbB-3, and c-erbB-4 was demonstrated in 36 (64%) of 56 papillary thyroid carcinomas. These findings suggest a common regulatory mechanism for the type I (epidermal growth factor receptor-related) receptors in papillary thyroid carcinomas and provide numerous possibilities for functional receptor interactions.
1 Supported by the Norwegian Cancer Society.
2 To whom requests for reprints should be addressed, at Department of Biochemistry and Molecular Biology, University of Bergen, Årstadveien 19, N-5009 Bergen, Norway.
Received 11/27/95. Accepted 1/31/96.
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