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[Cancer Research 56, 1253-1255, March 15, 1996]
© 1996 American Association for Cancer Research
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Taxol Induces bcl-2 Phosphorylation and Death of Prostate Cancer Cells1

Subrata Haldar2, Janaki Chintapalli and Carlo M. Croce

Jefferson Cancer Institute and Jefferson Cancer Center, Jefferson Medical College, Philadelphia, Pennsylvania 19107

Treatment of prostate cancer cell lines expressing bcl-2 with taxol induces bcl-2 phosphorylation and programmed cell death, whereas treatment of bcl-2-negative prostate cancer cells with taxol does not induce apoptosis. bcl-2 phosphorylation seems to inhibit its binding to bax since less bax was observed in immunocomplex with bcl-2 in taxol-treated cancer cells. These findings support the use of the anticancer drug taxol for the treatment of bcl-2-positive prostate cancers and other bcl-2-positive malignancies, such as follicular lymphoma.

1 This work was supported by the Council for Tobacco Research Grant 3496A (to S. H.) and National Cancer Institute Grant CA39860 (to C. M. C.).

2 To whom requests for reprints should be addressed, at Jefferson Cancer Institute, 233 South 10th Street, BLSB, Room 1032, Philadelphia, PA 19107-5799.

Received 1/ 5/96. Accepted 2/ 7/96.




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Home page
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Home page
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[Abstract] [Full Text] [PDF]

Home page
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Home page
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[Abstract] [Full Text] [PDF]

Home page
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Home page
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Home page
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Home page
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Home page
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