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[Cancer Research 56, 1279-1282, March 15, 1996]
© 1996 American Association for Cancer Research
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Increased Oxidative DNA Damage in Helicobacter pylori-infected Human Gastric Mucosa1

Seung-Chul Baik, Hee-Shang Youn, Myung-Hee Chung, Woo-Kon Lee, Myung-Je Cho, Gyung-Hyuck Ko, Cheol-Keun Park, Hiroshi Kasai and Kwang-Ho Rhee2

Departments of Microbiology, Pediatrics, and Pathology, Gyeongsang National University College of Medicine, Chinju, Kyung-Nam 660-280, Korea [S. C. B., H. S. Y., W. K. L., M. J. C., G. H. K., C. K. P., K. H. R.]; Department of Pharmacology, Seoul National University College of Medicine, Seoul 110-799, Korea [M. H. C.]; and Department of Environmental Oncology, Institute of Industrial Ecology Sciences, University of Occupational and Environmental Health, Kitakyushu, Japan [H. K.]

Helicobacter pylori causes type B gastritis. It shows strong association with the development of gastric carcinoma. A plausible hypothesis for the missing link between H. pylori infection and gastric carcinogenesis involves oxygen free radical-induced DNA damage. To test this hypothesis, we compared the amount of 8-hydroxydeoxyguanosine, a marker for oxygen free radical-induced DNA damage, in the DNA of human gastric mucosa with and without H. pylori infection. Gastric antral biopsies were taken from pediatric patients and volunteers to select H. pylori-positive and H. pylori-negative specimens. The 8-hydroxydeoxyguanosine content of the gastric mucosal DNA was measured after H. pylori-positive and H. pylori-negative volunteers were identified. The increased level of oxidative DNA damage suggests the mechanistic link between H. pylori infection and gastric carcinoma.

1 This work was supported by grants from the Korea Science and Engineering Foundation (KOSEF-SRC-56-CRC93-15) and from the Basic Medical Research Promotion Fund of the Ministry of Education, Korea.

2 To whom requests for reprints should be addressed, at Department of Microbiology, Gyeongsang National University College of Medicine, 92 Chilam-Dong, Chinju, Kyung-Nam 660-280, Korea. Phone: 82-591-50-8746; Fax: 82-591-759-1588.

Received 10/ 9/95. Accepted 1/30/96.




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