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Kimmel Cancer Institute and Kimmel Cancer Center, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19107 [D. R., S. A. S., M. N., E. C., C. M. C.], and the Weizmann Institute of Science, Rehovot 76100, Israel [E. C.]
The ALL1 gene is found rearranged in approximately 10% of acute lymphoblastic leukemias and in over 5% of acute myeloid leukemias. The gene undergoes fusion with either a variety of partner genes located on different chromosomes or with itself. To further characterize the role of the ALL1 gene in the leukemogenic process, and possibly in solid malignancies, we defined its complete genomic structure. The gene, which spans a region on chromosome band 11q23 approximately 90 kb in length, consists of 36 exons, ranging in size from 65 bp to 4249 bp. The determination of intronic sequences flanking the exon boundaries will allow the determination of whether point mutations may be responsible for inactivation of the gene in solid tumors showing loss of heterozygosity at region 11q23.
1 Supported by National Cancer Institute Grants CA39860 and CA50507, the Falk Medical Research Trust, and grants from the Israel Academy of Science and the United States-Israel Binational Fund.
2 To whom requests for reprints should be addressed, at Kimmel Cancer Institute, BLSB, Room 1050, 233 South Tenth Street, Philadelphia, PA 19107-5799.
Received 1/26/96. Accepted 2/23/96.
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