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Istituto Nazionale dei Tumori di Napoli, Fondazione Senatore Pascale, via M. Semmola, 80131 Napoli [M. F., G. C., S. B., G. V., A. C.], Dipartimento di Biochimica, Biofisica e Chimica delle Macromolecole, Università degli Studi di Trieste, via L. Giorgieri 1, 34127 Trieste [A. B., G. M., V. G.]; Dipartimento di Biologia e Patologia Cellulare e Molecolare c/o Centro di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Facoltà di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli "Federico II," via Pansini, 5, 80131 Napoli [M. S.], and Dipartimento di Medicina Sperimentale e Clinica, Facoltà di Medicina e Chirurgia di Catanzaro, Università di Reggio Calabria, via Tommaso Campanella, 88100 Catanzaro [A. F.], Italy
A correlation has previously been demonstrated between the presence of the three HMGI proteins (HMGI, HMGY, and HMGI-C) and the expression of a highly malignant phenotype in epithelial and fibroblastic rat thyroid cells; this being subsequently extended to experimental thyroid, lung, prostate, mammary, and skin carcinomas. Recently, we have demonstrated that expression of HMGI and HMGY proteins, coded for by the HMGI(Y) gene, is associated with the malignant phenotype of human thyroid neoplasias. Here, we show that HMGI(Y) gene expression is present both at the RNA and protein level in human colorectal carcinoma cell lines and tissues examined in this study. Conversely, no HMGI(Y) proteins were detected in normal intestinal mucosa. Therefore, these results suggest an involvement of HMGI and HMGY proteins overexpression in colorectal tumorigenesis.
1 This work was supported by grants from Associazione Italiana Ricerca Cancro (Progetto Speciale Oncosoppressori), Progetto Finalizzato "Applicazione Clinica della Ricerca Oncolognica," Progetto Finalizzato "Biotecnologie e Biostrumentazione" of the Consiglio Nazionale della Ricerche, the Università degli Studi di Trieste (60%), and Ministero della Ricerca Scientifica e Tecnologica (40%). S. B. and A. C. were recipients of an Associazione Italiana Ricerca Cancro fellowship.
2 To whom requests for reprints should be addressed. Phone: 39 81 7463056; Fax: 39 81 7463037 or 7701016.
Received 11/ 6/95. Accepted 2/12/96.
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