| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111 [D. C. S., L. V., D. B. B., T. C. H., A. K. G.], and Department of Microbiology and Immunology, Jefferson Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 [A. J. W.]
A second tumor suppressor locus on 17p that is distinct from TP53 has been identified in brain, breast, lung, and ovarian tumors. Using allelic loss mapping and positional cloning methods, we have recently identified two novel genes, which we refer to as OVCA1 and OVCA2, that map to 17p13.3. The two genes are ubiquitously expressed and encode proteins of 443 and 227 amino acids, respectively, with no known functional motifs. Sequence comparison of OVCA1 and OVCA2 revealed extensive sequence identity and similarity to hypothetical proteins from Saccharomyces cerevisiae, Caenorhabditis elegans, and Rattus species. Northern blot analysis reveals that OVCA1 and OVCA2 mRNA were expressed in normal surface epithelial cells of the ovary, but the level of this transcript is significantly reduced or is undetectable in 92% (11/12) of the ovarian tumors and tumor cell lines analyzed. The location, high degree of amino acid conservation, and reduced expression in ovarian tumors and tumor cell lines suggest that decreased expression of these two genes contributes to ovarian tumorigenesis and should be considered candidate tumor suppressor genes.
1 This work was supported in part by NIH Grant RO1 CA60643 (A. K. G.), the Hoxie Harrison Smith Foundation, the Mary Smith Charitable Lead Trust, Butler Family Fund, Emile Zola Chapter of Brith Shalom Women, and the Ladies Auxiliary to the Veterans of Foreign Wars of the United States of America.
2 These authors contributed equally to this work.
3 To whom requests for reprints should be addressed, at Department of Medical Oncology, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111. Phone: (215) 728-2557; Fax: (215) 728-2741.
Received 2/ 8/96. Accepted 3/18/96.
This article has been cited by other articles:
|
|
 |
|
  P. C.K. Leung and J.-H. Choi Endocrine signaling in ovarian surface epithelium and cancer Hum. Reprod. Update, March 1, 2007; 13(2): 143 - 162. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. He, B. J. Fenner, A. K. Godwin, and J. Kwang White Spot Syndrome Virus Open Reading Frame 222 Encodes a Viral E3 Ligase and Mediates Degradation of a Host Tumor Suppressor via Ubiquitination. J. Virol., April 1, 2006; 80(8): 3884 - 3892. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Quevillon-Cheruel, N. Leulliot, M. Graille, N. Hervouet, F. Coste, H. Benedetti, C. Zelwer, J. Janin, and H. Van Tilbeurgh Crystal structure of yeast YHR049W/FSH1, a member of the serine hydrolase family Protein Sci., May 1, 2005; 14(5): 1350 - 1356. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Nobukuni, K. Kohno, and K. Miyagawa Gene Trap Mutagenesis-based Forward Genetic Approach Reveals That the Tumor Suppressor OVCA1 Is a Component of the Biosynthetic Pathway of Diphthamide on Elongation Factor 2 J. Biol. Chem., March 18, 2005; 280(11): 10572 - 10577. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Zaim, E. Speina, and A. M. Kierzek Identification of New Genes Regulated by the Crt1 Transcription Factor, an Effector of the DNA Damage Checkpoint Pathway in Saccharomyces cerevisiae J. Biol. Chem., January 7, 2005; 280(1): 28 - 37. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Liu, G. T. Milne, J. G. Kuremsky, G. R. Fink, and S. H. Leppla Identification of the Proteins Required for Biosynthesis of Diphthamide, the Target of Bacterial ADP-Ribosylating Toxins on Translation Elongation Factor 2 Mol. Cell. Biol., November 1, 2004; 24(21): 9487 - 9497. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Baxter, J. S. Rosenblum, S. Knutson, M. R. Nelson, J. S. Montimurro, J. A. Di Gennaro, J. A. Speir, J. J. Burbaum, and J. S. Fetrow Synergistic Computational and Experimental Proteomics Approaches for More Accurate Detection of Active Serine Hydrolases in Yeast Mol. Cell. Proteomics, March 1, 2004; 3(3): 209 - 225. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. Jensen and K. Helin OVCA1: emerging as a bona fide tumor suppressor Genes & Dev., February 1, 2004; 18(3): 245 - 248. [Full Text] [PDF]
|
|
|
|
|
|
C.-M. Chen and R. R. Behringer Ovca1 regulates cell proliferation, embryonic development, and tumorigenesis Genes & Dev., February 1, 2004; 18(3): 320 - 332. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Lancaster, H. K. Dressman, R. S. Whitaker, L. Havrilesky, J. Gray, J. R. Marks, J. R. Nevins, and A. Berchuck Gene Expression Patterns That Characterize Advanced Stage Serous Ovarian Cancers Reproductive Sciences, January 1, 2004; 11(1): 51 - 59. [Abstract] [PDF]
|
|
|
|
 |
|
 A. Frolov, S. Chahwan, M. Ochs, J. P. Arnoletti, Z.-Z. Pan, O. Favorova, J. Fletcher, M. von Mehren, B. Eisenberg, and A. K. Godwin Response Markers and the Molecular Mechanisms of Action of Gleevec in Gastrointestinal Stromal Tumors Mol. Cancer Ther., August 1, 2003; 2(8): 699 - 709. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A H Prowse, D C Schultz, S Guo, L Vanderveer, J Dangel, B Bove, P Cairns, M Daly, and A K Godwin Identification of a splice acceptor site mutation in p16INK4A/p14ARF within a breast cancer, melanoma, neurofibroma prone kindred J. Med. Genet., August 1, 2003; 40(8): e102 - 102. [Full Text] [PDF]
|
|
|
|
 |
|
 K. Ott, H. Vogelsang, J. Mueller, K. Becker, M. Muller, U. Fink, J. R. Siewert, H. Hofler, and G. Keller Chromosomal Instability Rather Than p53 Mutation Is Associated with Response to Neoadjuvant Cisplatin-based Chemotherapy in Gastric Carcinoma Clin. Cancer Res., June 1, 2003; 9(6): 2307 - 2315. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Konishi, T. Nakagawa, T. Harano, K. Mizuno, H. Saito, A. Masuda, H. Matsuda, H. Osada, and T. Takahashi Identification of Frequent G2 Checkpoint Impairment and a Homozygous Deletion of 14-3-3{epsilon} at 17p13.3 in Small Cell Lung Cancers Cancer Res., January 1, 2002; 62(1): 271 - 276. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Gicquel, X. Bertagna, V. Gaston, J. Coste, A. Louvel, E. Baudin, J. Bertherat, Y. Chapuis, J.-M. Duclos, M. Schlumberger, et al. Molecular Markers and Long-Term Recurrences in a Large Cohort of Patients with Sporadic Adrenocortical Tumors Cancer Res., September 1, 2001; 61(18): 6762 - 6767. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Sekine, H. Nagata, S. Tsuji, Y. Hirai, S. Fujimoto, M. Hatae, I. Kobayashi, T. Fujii, I. Nagata, K. Ushijima, et al. Localization of a novel susceptibility gene for familial ovarian cancer to chromosome 3p22-p25 Hum. Mol. Genet., June 1, 2001; 10(13): 1421 - 1429. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Huang, N. Hu, A. M. Goldstein, M. R. Emmert-Buck, Z.-Z. Tang, M. J. Roth, Q.-H. Wang, S. M. Dawsey, X.-Y. Han, T. Ding, et al. High frequency allelic loss on chromosome 17p13.3-p11.1 in esophageal squamous cell carcinomas from a high incidence area in northern China Carcinogenesis, November 1, 2000; 21(11): 2019 - 2026. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Suzuki, D. H. Moore II, D. G. Ginzinger, T. E. Godfrey, J. Barclay, B. Powell, D. Pinkel, C. Zaloudek, K. Lu, G. Mills, et al. An Approach to Analysis of Large-Scale Correlations between Genome Changes and Clinical Endpoints in Ovarian Cancer Cancer Res., October 1, 2000; 60(19): 5382 - 5385. [Abstract] [Full Text]
|
|
|
|
|
|
J. R. Dunn, J. Garde, K. Dolan, J. R. Gosney, B. C. Oates, A. J. M. Watson, P. Fielding, and J. K. Field The Evolution of Loss of Heterozygosity on Chromosome 17 during the Progression to Barrett's Adenocarcinoma Involves a Unique Combination of Target Sites in Individual Specimens Clin. Cancer Res., October 1, 2000; 6(10): 4033 - 4042. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. Janke, K. Schluter, B. Jandrig, M. Theile, K. Kolble, W. Arnold, E. Grinstein, A. Schwartz, L. Estevez-Schwarz, P. M. Schlag, et al. Suppression of Tumorigenicity in Breast Cancer Cells by the Microfilament Protein Profilin 1 J. Exp. Med., May 8, 2000; 191(10): 1675 - 1686. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Bruening, A. H. Prowse, D. C. Schultz, M. Holgado-Madruga, A. Wong, and A. K. Godwin Expression of OVCA1, a Candidate Tumor Suppressor, Is Reduced in Tumors and Inhibits Growth of Ovarian Cancer Cells Cancer Res., October 1, 1999; 59(19): 4973 - 4983. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Guerardel, S. Deltour, S. Pinte, D. Monte, A. Begue, A. K. Godwin, and D. Leprince Identification in the Human Candidate Tumor Suppressor Gene HIC-1 of a New Major Alternative TATA-less Promoter Positively Regulated by p53 J. Biol. Chem., January 26, 2001; 276(5): 3078 - 3089. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
