| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Scientific Applications International Corporation [Z-q. C., R. J. F.], Data Management Services [C. W. R.], Laboratory of Biochemical Physiology [J. S. R.], and Laboratory of Genomic Diversity [J. A. L.], National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland 21702-1201
Vascular endothelial growth factor (VEGF) increased the level of ETS1 mRNA in human umbilical vein endothelial cells (HUVEC) and human lung microvascular endothelial cells (HMVEC-L) over 5-fold. Protein levels were shown to increase concordantly. VEGF was also found to stimulate the invasiveness of endothelial cells as measured by migration through Matrigel- or gelatin-coated membranes. The VEGF-induced invasiveness was inhibited by ETS1 antisense oligonucleotides but not by a sense control. In addition, the ETS1 antisense oligonucleotides reduced the levels of ETS1 and urokinase-type plasminogen activator mRNAs. The antisense oligonucleotides directed against the ETS1 gene thus altered a cellular property of endothelial cells that is correlated with the ability of the cells to migrate through basement membranes. Together, these observations demonstrate a direct role for the ETS1 gene in angiogenesis.
1 To whom requests for reprints should be addressed, at NIH-Frederick Cancer Research and Development Center, P. O. Box B, Bldg. 560, Room 21-49, Frederick, MD 21702-1201.
Received 11/27/96. Accepted 3/17/97.
This article has been cited by other articles:
|
|
 |
|
  Md. R. Abid, K. C. Spokes, S.-C. Shih, and W. C. Aird NADPH Oxidase Activity Selectively Modulates Vascular Endothelial Growth Factor Signaling Pathways J. Biol. Chem., November 30, 2007; 282(48): 35373 - 35385. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Md. R. Abid, S.-C. Shih, H. H. Otu, K. C. Spokes, Y. Okada, D. T. Curiel, T. Minami, and W. C. Aird A Novel Class of Vascular Endothelial Growth Factor-responsive Genes That Require Forkhead Activity for Expression J. Biol. Chem., November 17, 2006; 281(46): 35544 - 35553. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Murakami, S. Yamagoe, K. Noguchi, Y. Takebe, N. Takahashi, Y. Uehara, and H. Fukazawa Ets-1-dependent Expression of Vascular Endothelial Growth Factor Receptors Is Activated by Latency-associated Nuclear Antigen of Kaposi's Sarcoma-associated Herpesvirus through Interaction with Daxx J. Biol. Chem., September 22, 2006; 281(38): 28113 - 28121. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Md. R. Abid, I. G. Schoots, K. C. Spokes, S.-Q. Wu, C. Mawhinney, and W. C. Aird Vascular Endothelial Growth Factor-mediated Induction of Manganese Superoxide Dismutase Occurs through Redox-dependent Regulation of Forkhead and I{kappa}B/NF-{kappa}B J. Biol. Chem., October 15, 2004; 279(42): 44030 - 44038. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Nakamura, S. Esnault, T. Maeda, E. A. B. Kelly, J. S. Malter, and N. N. Jarjour Ets-1 Regulates TNF-{alpha}-Induced Matrix Metalloproteinase-9 and Tenascin Expression in Primary Bronchial Fibroblasts J. Immunol., February 1, 2004; 172(3): 1945 - 1952. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Wasylyk, S. E. Schlumberger, P. Criqui-Filipe, and B. Wasylyk Sp100 Interacts with ETS-1 and Stimulates Its Transcriptional Activity Mol. Cell. Biol., April 15, 2002; 22(8): 2687 - 2702. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. K. Lindemann, P. Ballschmieter, A. Nordheim, and J. Dittmer Transforming Growth Factor beta Regulates Parathyroid Hormone-related Protein Expression in MDA-MB-231 Breast Cancer Cells through a Novel Smad/Ets Synergism J. Biol. Chem., November 30, 2001; 276(49): 46661 - 46670. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Zachary and G. Gliki Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family Cardiovasc Res, February 16, 2001; 49(3): 568 - 581. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Dube, S. Thai, J. Gaspar, S. Rudders, T. A. Libermann, L. Iruela-Arispe, and P. Oettgen ELF-1 Is a Transcriptional Regulator of the Tie2 Gene During Vascular Development Circ. Res., February 2, 2001; 88(2): 237 - 244. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Ozaki, T. Mizuta, G. Zhao, H. Yotsumoto, T. Hara, S. Kajihara, A. Hisatomi, T. Sakai, and K. Yamamoto Involvement of the Ets-1 Gene in Overexpression of Matrilysin in Human Hepatocellular Carcinoma Cancer Res., November 1, 2000; 60(22): 6519 - 6525. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. W. Griffioen and G. Molema Angiogenesis: Potentials for Pharmacologic Intervention in the Treatment of Cancer, Cardiovascular Diseases, and Chronic Inflammation Pharmacol. Rev., June 1, 2000; 52(2): 237 - 268. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Ko, E. Miyoshi, K. Noda, A. Ekuni, R. Kang, Y. Ikeda, and N. Taniguchi Regulation of the GnT-V Promoter by Transcription Factor Ets-1 in Various Cancer Cell Lines J. Biol. Chem., August 13, 1999; 274(33): 22941 - 22948. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Dube, Y. Akbarali, T. N. Sato, T. A. Libermann, and P. Oettgen Role of the Ets Transcription Factors in the Regulation of the Vascular-Specific Tie2 Gene Circ. Res., May 28, 1999; 84(10): 1177 - 1185. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ware, A Wells, and D. Lauffenburger Epidermal growth factor alters fibroblast migration speed and directional persistence reciprocally and in a matrix-dependent manner J. Cell Sci., January 8, 1998; 111(16): 2423 - 2432. [Abstract] [PDF]
|
|
|
|
|
|
A Delannoy-Courdent, V Mattot, V Fafeur, W Fauquette, I Pollet, T Calmels, C Vercamer, B Boilly, B Vandenbunder, and X Desbiens The expression of an Ets1 transcription factor lacking its activation domain decreases uPA proteolytic activity and cell motility, and impairs normal tubulogenesis and cancerous scattering in mammary epithelial cells J. Cell Sci., January 6, 1998; 111(11): 1521 - 1534. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
