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First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602, Japan
We investigated the efficacy of hyperthermia and 
-linolenic acid on experimental carcinoma. This study focused on polyunsaturated fatty acids that are substrates for free radical reactions. Oleic acid, linolenic acid, 
-linolenic acid, or -linolenic acid was injected into the arteries feeding AH109A carcinoma implanted into rat hind limbs. Among these, -linolenic acid had the greatest effect on tumor tissue lipid peroxidation and demonstrated an antitumor effect. Consequently, -linolenic acid injection into the feeding artery of a tumor was performed immediately prior to hyperthermia. This combination therapy induced a high level of lipid peroxidation in tumor tissue and a significant antitumor effect. Hyperthermia combined with -linolenic acid produces free radical reactions by increasing the radical reaction substrate and may be an effective anticancer modality.
1 To whom requests for reprints should be addressed. Phone: 81-75-251-5505; Fax: 81-75-252-3721.
Received 12/ 2/96. Accepted 4/ 2/97.
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