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Comparisons of CYP2D Messenger RNA Splice Variant Profiles in Human Lung Tumors and Normal Tissues

Department of Environmental Health and Toxicology, School of Public Health, University at Albany, State University of New York, Albany, New York 12201 [Z. H., M. J. F., S. S., L. S. K.]; New York State Department of Health, Wadsworth Center, Albany, New York 12201-0509 [M. J. F., L. S. K.]; and Department of Pulmonary and Critical Care Medicine, Albany Medical College, Albany, New York 12208 [S. S.]

Allelic variants of the CYP2D6 gene, a member of the cytochrome P450 gene superfamily, have been implicated in susceptibility to lung carcinogenesis. Human breast CYP2D6 and CYP2D7P (from a pseudogene) mRNAs were previously reported to be expressed as a series of splice variants. In this study, the expression of full-length and splice variants of these mRNAs in human lung tissue and tumors are reproted for the first time and are compared in order to probe the potential for differential CYP2D6 regulation in lung normal tissue and tumors. The splice variant profiles differed within the same individual, but no consistent differences were detected.

¹ To whom requests for reprints should be addressed, at Wadsworth Center, New York State Department of Health, Empire State Plaza, P. O. Box 509, Albany, NY 12201-0509. Phone: (518) 474-4920; Fax: (518) 486-1505.

Received 4/16/97. Accepted 5/13/97.

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