Cancer Research Infection and Cancer: Biology, Therapeutics, and Prevention Susan G. Komen for the Cure-AACR Outstanding Investigator Award for Breast Cancer Research
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Cell Growth & Differentiation
[Cancer Research 57, 2860-2864, July 15, 1997]
© 1997 American Association for Cancer Research
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Richter, J.
Right arrow Articles by Sauter, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Richter, J.
Right arrow Articles by Sauter, G.

Marked Genetic Differences between Stage pTa and Stage pT1 Papillary Bladder Cancer Detected by Comparative Genomic Hybridization1

Jan Richter2, Feng Jiang2, Jean-Philippe Görög2, Gideon Sartorius2, Carole Egenter, Thomas C. Gasser, Holger Moch, Michael J. Mihatsch and Guido Sauter3

Institute of Pathology [J. R., F. J., J-P. G., G. Sar., C. E., H. M., M. J. M., G. Sau.] and Urological Clinics [T. C. G.], University of Basel, Schonbeinstrasse 40, CH-4003 Basel, Switzerland

Little is known about the genetic changes underlying invasive tumor growth in bladder cancer. Because alterations that are linked to invasive tumor growth may be detectable in minimally invasive (stage pT1) but not in noninvasive (stage pTa) tumors, we searched for genetic differences between 28 pTa and 28 papillary pT1 bladder tumors by comparative genomic hybridization. Losses of 9q (54%), 9p (39%), and Y (28%) and gains of 1q (14%) were most prevalent in pTa tumors. These changes may play a role in the initiation of noninvasive papillary bladder cancer. The total number of aberrations was higher in pT1 tumors (6.5 ± 5.4) than in pTa tumors (2.3 ± 2.1; P = 0.0003), suggesting an increased genetic instability at stage pT1. Specific alterations, which were significantly more frequent in pT1 than in pTa tumors (P ≤ 0.05), included deletions at 2q (36% of pT1 tumros), 8p (32%), and 11p (21%) and gains at 1q (54%), 8q (32%), 3p, 3q, 5p, 6p, and 10p (18% each). These loci are candidates for carrying genes involved in invasive tumor growth in bladder cancer. High-level amplifications at 1q22–24, 3p24–25, 6p22, 8p12, 8q21–22, 10p12.1–14, 11q13, 12q15–21, 13q31–33, Xp11–13, and Xq21–22.2 may pinpoint the location of oncogenes with relevance for bladder cancer.

1 This study was supported by Schweizerische Krebsliga Grant SKL 137-7-1995, Krebsliga Beider Basel, Schweizerischer Nationalfonds Grant NF 3200-043969.95.1, Wilhelm-Sander Stiftung Grant 97.005.1, and Stiftung für Klinische Krebsforschung der Onkologischen Abteilung des Kantonsspitals Basel.

2 These authors have contributed equally to this work.

3 To whom requests for reprints should be addressed.

Received 4/ 4/97. Accepted 5/28/97.




This article has been cited by other articles:


Home page
 Clin. Cancer Res.Home page
A. Veerakumarasivam, H. E. Scott, S.-F. Chin, A. Warren, M. J. Wallard, D. Grimmer, K. Ichimura, C. Caldas, V. P. Collins, D. E. Neal, et al.
High-Resolution Array-Based Comparative Genomic Hybridization of Bladder Cancers Identifies Mouse Double Minute 4 (MDM4) as an Amplification Target Exclusive of MDM2 and TP53
Clin. Cancer Res., May 1, 2008; 14(9): 2527 - 2534.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Surg. Oncol.Home page
C. Schleicher, C. Poremba, H. Wolters, K.-L. Schafer, N. Senninger, and M. Colombo-Benkmann
Gain of Chromosome 8q: A Potential Prognostic Marker in Resectable Adenocarcinoma of the Pancreas?
Ann. Surg. Oncol., April 1, 2007; 14(4): 1327 - 1335.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
K. N. Blehm, P. E. Spiess, J. E. Bondaruk, M. E. Dujka, G. J. Villares, Y.-j. Zhao, O. Bogler, K. D. Aldape, H. B. Grossman, L. Adam, et al.
Mutations Within the Kinase Domain and Truncations of the Epidermal Growth Factor Receptor Are Rare Events in Bladder Cancer: Implications for Therapy
Clin. Cancer Res., August 1, 2006; 12(15): 4671 - 4677.
[Abstract] [Full Text] [PDF]

Home page
 INT J SURG PATHOLHome page
R. Montironi and A. Lopez-Beltran
The 2004 WHO Classification of Bladder Tumors: A Summary and Commentary
International Journal of Surgical Pathology, April 1, 2005; 13(2): 143 - 153.
[Abstract] [PDF]

Home page
 Cancer Res.Home page
K. Koed, C. Wiuf, L.-L. Christensen, F. P. Wikman, K. Zieger, K. Moller, H. von der Maase, and T. F. Orntoft
High-Density Single Nucleotide Polymorphism Array Defines Novel Stage and Location-Dependent Allelic Imbalances in Human Bladder Tumors
Cancer Res., January 1, 2005; 65(1): 34 - 45.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
A. J. Evans, B. L. Gallie, M. A.S. Jewett, G. R. Pond, K. Vandezande, J. Underwood, Y. Fradet, G. Lim, P. Marrano, M. Zielenska, et al.
Defining a 0.5-Mb Region of Genomic Gain on Chromosome 6p22 in Bladder Cancer by Quantitative-Multiplex Polymerase Chain Reaction
Am. J. Pathol., January 1, 2004; 164(1): 285 - 293.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. A. Bakkar, H. Wallerand, F. Radvanyi, J.-B. Lahaye, S. Pissard, L. Lecerf, J. C. Kouyoumdjian, C. C. Abbou, J.-C. Pairon, M.-C. Jaurand, et al.
FGFR3 and TP53 Gene Mutations Define Two Distinct Pathways in Urothelial Cell Carcinoma of the Bladder
Cancer Res., December 1, 2003; 63(23): 8108 - 8112.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
R. Natrajan, J. Louhelainen, S. Williams, J. Laye, and M. A. Knowles
High-Resolution Deletion Mapping of 15q13.2-q21.1 in Transitional Cell Carcinoma of the Bladder
Cancer Res., November 15, 2003; 63(22): 7657 - 7662.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. A. Veltman, J. Fridlyand, S. Pejavar, A. B. Olshen, J. E. Korkola, S. DeVries, P. Carroll, W.-L. Kuo, D. Pinkel, D. Albertson, et al.
Array-based Comparative Genomic Hybridization for Genome-Wide Screening of DNA Copy Number in Bladder Tumors
Cancer Res., June 1, 2003; 63(11): 2872 - 2880.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
L. E. Moore, A. H. Smith, C. Eng, D. Kalman, S. DeVries, V. Bhargava, K. Chew, D. Moore II, C. Ferreccio, O. A. Rey, et al.
Arsenic-Related Chromosomal Alterations in Bladder Cancer
J Natl Cancer Inst, November 20, 2002; 94(22): 1688 - 1696.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
S. Sen, H. Zhou, R.-D. Zhang, D. S. Yoon, F. Vakar-Lopez, S. Ito, F. Jiang, D. Johnston, H. B. Grossman, A. C. Ruifrok, et al.
Amplification/Overexpression of a Mitotic Kinase Gene in Human Bladder Cancer
J Natl Cancer Inst, September 4, 2002; 94(17): 1320 - 1329.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. Fabarius, A. Willer, G. Yerganian, R. Hehlmann, and P. Duesberg
Specific aneusomies in Chinese hamster cells at different stages of neoplastic transformation, initiated by nitrosomethylurea
PNAS, May 14, 2002; 99(10): 6778 - 6783.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
A. Vecchione, H. Ishii, G. Baldassarre, P. Bassi, F. Trapasso, H. Alder, F. Pagano, L. G. Gomella, C. M. Croce, and R. Baffa
FEZ1/LZTS1 Is Down-Regulated in High-Grade Bladder Cancer, and Its Restoration Suppresses Tumorigenicity in Transitional Cell Carcinoma Cells
Am. J. Pathol., April 1, 2002; 160(4): 1345 - 1352.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
H. Primdahl, F. P. Wikman, H. von der Maase, X.-g. Zhou, H. Wolf, and T. F. Orntoft
Allelic Imbalances in Human Bladder Cancer: Genome-Wide Detection With High-Density Single-Nucleotide Polymorphism Arrays
J Natl Cancer Inst, February 6, 2002; 94(3): 216 - 223.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. ProteomicsHome page
T. F. Orntoft, T. Thykjaer, F. M. Waldman, H. Wolf, and J. E. Celis
Genome-wide Study of Gene Copy Numbers, Transcripts, and Protein Levels in Pairs of Non-invasive and Invasive Human Transitional Cell Carcinomas
Mol. Cell. Proteomics, January 1, 2002; 1(1): 37 - 45.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pathol.Home page
M A Knowles
What we could do now: molecular pathology of bladder cancer
Mol. Pathol., August 1, 2001; 54(4): 215 - 221.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
E. J. M. Speel, A. F. Scheidweiler, J. Zhao, C. Matter, P. Saremaslani, J. Roth, P. U. Heitz, and P. Komminoth
Genetic Evidence for Early Divergence of Small Functioning and Nonfunctioning Endocrine Pancreatic Tumors: Gain of 9Q34 Is an Early Event in Insulinomas
Cancer Res., July 1, 2001; 61(13): 5186 - 5192.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
R. Simon, J. Richter, U. Wagner, A. Fijan, J. Bruderer, U. Schmid, D. Ackermann, R. Maurer, G. Alund, H. Knonagel, et al.
High-Throughput Tissue Microarray Analysis of 3p25 (RAF1) and 8p12 (FGFR1) Copy Number Alterations in Urinary Bladder Cancer
Cancer Res., June 1, 2001; 61(11): 4514 - 4519.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
H. Dannenberg, R. R. de Krijger, J. Zhao, E. J.M. Speel, P. Saremaslani, W. N. M. Dinjens, W. J. Mooi, J. Roth, P. U. Heitz, and P. Komminoth
Differential Loss of Chromosome 11q in Familial and Sporadic Parasympathetic Paragangliomas Detected by Comparative Genomic Hybridization
Am. J. Pathol., June 1, 2001; 158(6): 1937 - 1942.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
H Tonnies, M R Toliat, C Ramel, U F Pape, H Neitzel, W Berger, and B Wiedenmann
Analysis of sporadic neuroendocrine tumours of the enteropancreatic system by comparative genomic hybridisation
Gut, April 1, 2001; 48(4): 536 - 541.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
R. Simon, E. Eltze, K.-L. Schäfer, H. Bürger, A. Semjonow, L. Hertle, B. Dockhorn-Dworniczak, H.-J. Terpe, and W. Böcker
Cytogenetic Analysis of Multifocal Bladder Cancer Supports a Monoclonal Origin and Intraepithelial Spread of Tumor Cells
Cancer Res., January 1, 2001; 61(1): 355 - 362.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
P. Duesberg, R. Stindl, and R. Hehlmann
Explaining the high mutation rates of cancer cells to drug and multidrug resistance by chromosome reassortments that are catalyzed by aneuploidy
PNAS, December 19, 2000; 97(26): 14295 - 14300.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
F. Jiang, R. Desper, C. H. Papadimitriou, A. A. Schäffer, O.-P. Kallioniemi, J. Richter, P. Schraml, G. Sauter, M. J. Mihatsch, and H. Moch
Construction of Evolutionary Tree Models for Renal Cell Carcinoma from Comparative Genomic Hybridization Data
Cancer Res., November 1, 2000; 60(22): 6503 - 6509.
[Abstract] [Full Text]

Home page
 CarcinogenesisHome page
M. Muscheck, H. Abol-Enein, K. Chew, D. Moore II, V. Bhargava, M.A. Ghoneim, P.R. Carroll, and F.M. Waldman
Comparison of genetic changes in schistosome-related transitional and squamous bladder cancers using comparative genomic hybridization
Carcinogenesis, September 1, 2000; 21(9): 1721 - 1726.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
J. Richter, U. Wagner, J. Kononen, A. Fijan, J. Bruderer, U. Schmid, D. Ackermann, R. Maurer, G. Alund, H. Knonagel, et al.
High-Throughput Tissue Microarray Analysis of Cyclin E Gene Amplification and Overexpression in Urinary Bladder Cancer
Am. J. Pathol., September 1, 2000; 157(3): 787 - 794.
[Abstract] [Full Text] [PDF]

Home page
 J. Mol. Diagn.Home page
I. A. Sokolova, K. C. Halling, R. B. Jenkins, H. M. Burkhardt, R. G. Meyer, S. A. Seelig, and W. King
The Development of a Multitarget, Multicolor Fluorescence in Situ Hybridization Assay for the Detection of Urothelial Carcinoma in Urine
J. Mol. Diagn., August 1, 2000; 2(3): 116 - 123.
[Abstract] [Full Text]

Home page
 Cancer Res.Home page
J. Bruch, W. A. Schulz, J. Häussler, I. Melzner, S. Brüderlein, P. Möller, R. Kemmerling, W. Vogel, and H. Hameister
Delineation of the 6p22 Amplification Unit in Urinary Bladder Carcinoma Cell Lines
Cancer Res., August 1, 2000; 60(16): 4526 - 4530.
[Abstract] [Full Text]

Home page
 Cancer Res.Home page
A. Schneider, S. Borgnat, H. Lang, O. Régine, V. Lindner, M. Kassem, C. Saussine, P. Oudet, D. Jacqmin, and M. P. Gaub
Evaluation of Microsatellite Analysis in Urine Sediment for Diagnosis of Bladder Cancer
Cancer Res., August 1, 2000; 60(16): 4617 - 4622.
[Abstract] [Full Text]

Home page
 Am. J. Pathol.Home page
H. Dannenberg, E. J.M. Speel, J. Zhao, P. Saremaslani, E. van der Harst, J. Roth, P. U. Heitz, H. J. Bonjer, W. N.M. Dinjens, W. J. Mooi, et al.
Losses of Chromosomes 1p and 3q Are Early Genetic Events in the Development of Sporadic Pheochromocytomas
Am. J. Pathol., August 1, 2000; 157(2): 353 - 359.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
C.-X. Liu, S. Musco, N. M. Lisitsina, E. Forgacs, J. D. Minna, and N. A. Lisitsyn
LRP-DIT, a Putative Endocytic Receptor Gene, Is Frequently Inactivated in Non-Small Cell Lung Cancer Cell Lines
Cancer Res., April 1, 2000; 60(7): 1961 - 1967.
[Abstract] [Full Text]

Home page
 Am. J. Pathol.Home page
W.’e. El-Rifai, D. Kamel, M. L. Larramendy, S. Shoman, Y. Gad, S. Baithun, M. El-Awady, S. Eissa, H. Khaled, S. Soloneski, et al.
DNA Copy Number Changes in Schistosoma-Associated and Non-Schistosoma-Associated Bladder Cancer
Am. J. Pathol., March 1, 2000; 156(3): 871 - 878.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
E. J. M. Speel, J. Richter, H. Moch, C. Egenter, P. Saremaslani, K. Rutimann, J. Zhao, A. Barghorn, J. Roth, P. U. Heitz, et al.
Genetic Differences in Endocrine Pancreatic Tumor Subtypes Detected by Comparative Genomic Hybridization
Am. J. Pathol., December 1, 1999; 155(6): 1787 - 1794.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. Richter, U. Wagner, P. Schraml, R. Maurer, G. Alund, H. Knonagel, H. Moch, M. J. Mihatsch, T. C. Gasser, and G. Sauter
Chromosomal Imbalances Are Associated with a High Risk of Progression in Early Invasive (pT1) Urinary Bladder Cancer
Cancer Res., November 1, 1999; 59(22): 5687 - 5691.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
J. Zhao, E. J. M. Speel, S. Muletta-Feurer, K. Rutimann, P. Saremaslani, J. Roth, P. U. Heitz, and P. Komminoth
Analysis of Genomic Alterations in Sporadic Adrenocortical Lesions : Gain of Chromosome 17 Is an Early Event in AdrenocorticalTumorigenesis
Am. J. Pathol., October 1, 1999; 155(4): 1039 - 1045.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. Zhao, J. Richter, U. Wagner, B. Roth, P. Schraml, T. Zellweger, D. Ackermann, U. Schmid, H. Moch, M. J. Mihatsch, et al.
Chromosomal Imbalances in Noninvasive Papillary Bladder Neoplasms (pTa)
Cancer Res., September 1, 1999; 59(18): 4658 - 4661.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
S. Knuutila, Y. Aalto, K. Autio, A.-M. Bjorkqvist, W.'e. El-Rifai, S. Hemmer, T. Huhta, E. Kettunen, S. Kiuru-Kuhlefelt, M. L. Larramendy, et al.
DNA Copy Number Losses in Human Neoplasms
Am. J. Pathol., September 1, 1999; 155(3): 683 - 694.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. Dellas, J. Torhorst, F. Jiang, J. Proffitt, E. Schultheiss, W. Holzgreve, G. Sauter, M. J. Mihatsch, and H. Moch
Prognostic Value of Genomic Alterations in Invasive Cervical Squamous Cell Carcinoma of Clinical Stage IB Detected by Comparative Genomic Hybridization
Cancer Res., July 1, 1999; 59(14): 3475 - 3479.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
H. Bissig, J. Richter, R. Desper, V. Meier, P. Schraml, A. A. Schaffer, G. Sauter, M. J. Mihatsch, and H. Moch
Evaluation of the Clonal Relationship between Primary and Metastatic Renal Cell Carcinoma by Comparative Genomic Hybridization
Am. J. Pathol., July 1, 1999; 155(1): 267 - 274.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
A. Hartmann, K. Moser, M. Kriegmair, A. Hofstetter, F. Hofstaedter, and R. Knuechel
Frequent Genetic Alterations in Simple Urothelial Hyperplasias of the Bladder in Patients with Papillary Urothelial Carcinoma
Am. J. Pathol., March 1, 1999; 154(3): 721 - 727.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
E. D. Lobban, B. A. Smith, G. D. Hall, P. Harnden, P. Roberts, P. J. Selby, L. K. Trejdosiewicz, and J. Southgate
Uroplakin Gene Expression by Normal and Neoplastic Human Urothelium
Am. J. Pathol., December 1, 1998; 153(6): 1957 - 1967.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
F. Jiang, J. Richter, P. Schraml, L. Bubendorf, T. Gasser, G. Sauter, M. J. Mihatsch, and H. Moch
Chromosomal Imbalances in Papillary Renal Cell Carcinoma : Genetic Differences between Histological Subtypes
Am. J. Pathol., November 1, 1998; 153(5): 1467 - 1473.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
J. Richter, L. Beffa, U. Wagner, P. Schraml, T. C. Gasser, H. Moch, M. J. Mihatsch, and G. Sauter
Patterns of Chromosomal Imbalances in Advanced Urinary Bladder Cancer Detected by Comparative Genomic Hybridization
Am. J. Pathol., November 1, 1998; 153(5): 1615 - 1621.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
O. Monni, M. Barlund, S. Mousses, J. Kononen, G. Sauter, M. Heiskanen, P. Paavola, K. Avela, Y. Chen, M. L. Bittner, et al.
Comprehensive copy number and gene expression profiling of the 17q23 amplicon in human breast cancer
PNAS, May 8, 2001; 98(10): 5711 - 5716.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Cell Growth & Differentiation
Copyright © 1997 by the American Association for Cancer Research.