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Institute for Biodiagnostics, National Research Council, Winnipeg, R3B 1Y6 [P. H., I. C. P. S., R. L. S., T. B.], Manitoba Cancer Research and Treatment Foundation, Winnipeg, R3E 0V9 [P. H.], Winnipeg Clinic, Winnipeg, R3C 0N2 [L. L.], and Department of Pathology, University of Manitoba, Winnipeg, R3A 1R9 [C. L.], Manitoba, Canada
1H magnetic resonance spectroscopy studies (360 MHz) were performed on specimens of benign (n = 66) and malignant (n = 21) human prostate tissue from 50 patients, and the spectral data were subjected to multivariate analysis, specifically linear-discriminant analysis. On the basis of histopathological assessments, an overall classification accuracy of 96.6% was achieved, with a sensitivity of 100% and a specificity of 95.5% in classifying benign prostatic hyperplasia from prostatic cancer. Resonances due to citrate, glutamate, and taurine were among the six spectral subregions identified by our algorithm as having diagnostic potential. Significantly higher levels of citrate were observed in glandular than in stromal benign prostatic hyperplasia (P < 0.05). This method shows excellent promise for the possibility of in vivo assessment of prostate tissue by magnetic resonance.
1 To whom requests for reprints should be addressed, at the Institute for Biodiagnostics, National Research Council, 435 Ellice Avenue, Winnipeg, Manitoba, Canada R3B 1Y6. Fax: (204) 984-4722; E-mail: ismith@ibd.nrc.ca.
Received 1/14/97. Accepted 6/17/97.
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