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Fine Mapping of a Genetic Locus for Peutz-Jeghers Syndrome on Chromosome 19p¹

Department of Epidemiology, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030 [C. I. A., T. J. T., A. Y.]; Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710 [D. B.]; University of Texas-Houston, Graduate School of Biomedical Sciences, Houston, Texas, 77030 [T. J. T.]; Rowe Program in Genetics, Departments of Biological Chemistry and Medicine, University of California at Davis, Davis, California 95616 [J. P. A., M. F. S.]; Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104 [I. G.]; Department of Gastrointestinal Oncology and Digestive Disease, University of Texas M. D. Anderson Cancer Center, Houston, Texas, 77030 [M. L. F., P. M. L.]; West Michigan Hereditary Cancer Prevention Network, Blodgett Memorial Medical Center, Feguson, Blodgett Digestive Disease Institute, Grand Rapids, Michigan 49503 [M. A. L.]; and Division of Gastroenterology, Department of Medicine, College of Medicine, University Hospital, The Milton S. Hershey Medical Center, Pennsylvania State University, Hershey, Pennsylvania 17033 [T. J. M.]

Peutz-Jeghers syndrome (PJS) was recently mapped in a single report to the telomeric region of chromosome 19p (A. Hemminki et al., Nat. Genet., 15: 87–90, 1997). Our studies confirm this location and provide further localization of the PJS locus. In the five families examined, there were no recombinants with the marker D19S886. The multipoint log odds score at D19S886 is 7.52, and we found no evidence for genetic heterogeneity. We also found that all carriers expressed the PJS phenotype and no noncarriers displayed PJS sequellae, indicating complete penetrance with no sporadic cases.

¹ This work was supported by NIH Grants CA19972, GM52607, HG00734, and NIH/NIAID 5T32AIO7217.

² To whom requests for reprints should be addressed, at the Department of Epidemiology, Box 189, University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030. Phone: (713) 745-2480; Fax: (713) 792-0807; E-mail: camos@request.mdacc.tmc.edu.

Received 5/29/97. Accepted 7/18/97.

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