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Differential Messenger RNA and Protein Expression of the Receptor for Advanced Glycosylated End Products in Normal Lung and Non-Small Cell Lung Carcinoma¹

Department of Research, University Hospital Basel, CH-4031 Basel, Switzerland

The receptor for advanced glycosylated end products (RAGE), a member of the immunoglobulin superfamily, was one of the cDNA subtraction clones that was found to be differentially expressed in human lung and the corresponding tumor tissue. In nine additional matched normal/tumor pairs, a strongly reduced or missing expression, not only on a transcriptional level but also on a protein level, was demonstrated in the non-small cell lung carcinoma tissue. Because amphoterin, a physiological ligand of RAGE that is highly expressed in the lung, mediates cell differentiation via RAGE, a down-regulation of the receptor may be considered as a critical step in lung tumor formation. Furthermore, we determined the complete reading frame of RAGE.

¹ This work was supported by Swiss National Foundation Grant 31-45851.95 from the Swiss National Research Foundation.

² To whom requests for reprints should be addressed, at Department of Research, University Hospital Basel, Laboratory 405, Hebelstrasse 20, CH-4031 Basel, Switzerland. Phone: 41 61 2652387; Fax: 41 61 2652350.

Received 5/19/97. Accepted 7/17/97.

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