This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by McGregor, F. Articles by Harrison, P. R. Search for Related Content PubMed PubMed Citation Articles by McGregor, F. Articles by Harrison, P. R.

Inappropriate Retinoic Acid Receptor-ß Expression in Oral Dysplasias: Correlation with Acquisition of the Immortal Phenotype¹

The Beatson Institute for Cancer Research, CRC Beatson Laboratories, Bearsden, Glasgow G61 1BD [F. M., E. W., K. P., P. R. H.], Department of Plastic Surgery, Canniesburn Hospital, Bearsden, Glasgow G61 1QL [D. S.], and Department of Oral Medicine, The Dental School, Glasgow G2 3JZ [D. F.], Scotland

Retinoids are useful in the treatment of premalignant oral lesions and in preventing the occurrence of second primary cancers after resection of the initial primary oral cancer, but long-term prognosis is still poor, presumably due to malignant cells escaping retinoid control. Previous work has shown that loss of expression of retinoic acid receptor ß is one of the most consistent molecular changes during oral cancer progression in vivo. In this report we demonstrate, using a novel panel of primary cultures of oral lesions, that loss of retinoic acid receptor ß expression at the dysplasia stage occurs during the transition from senescent to immortal phenotype but may occur independently to the loss of CDKN2A/p16 expression.

¹ The work of F. M. on this project was supported by the Association for International Cancer Research. P. R. H. and K. P. are supported by the Cancer Research Campaign.

² To whom requests for reprints should be addressed, at The Beatson Institute for Cancer Research, CRC Beatson Laboratories, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, Scotland.

Received 7/16/97. Accepted 7/31/97.

This article has been cited by other articles:

				S. Song, B. Guan, T. Men, A. Hoque, R. Lotan, and X.-C. Xu Antitumor Effect of Retinoic Acid Receptor-{beta}2 Associated with Suppression of Cyclooxygenase-2 Cancer Prevention Research, March 1, 2009; 2(3): 274 - 280. [Abstract] [Full Text] [PDF]

				K. D. Hunter, J. K. Thurlow, J. Fleming, P. J.H. Drake, J. K. Vass, G. Kalna, D. J. Higham, P. Herzyk, D. G. MacDonald, E. K. Parkinson, et al. Divergent routes to oral cancer. Cancer Res., August 1, 2006; 66(15): 7405 - 7413. [Abstract] [Full Text] [PDF]

				E. M. Youssef, D. Lotan, J.-P. Issa, K. Wakasa, Y.-H. Fan, L. Mao, K. Hassan, L. Feng, J. J. Lee, S. M. Lippman, et al. Hypermethylation of the Retinoic Acid Receptor-{beta}2 Gene in Head and Neck Carcinogenesis Clin. Cancer Res., March 1, 2004; 10(5): 1733 - 1742. [Abstract] [Full Text] [PDF]

				J. Brown, J. O'Prey, and P.R. Harrison Enhanced sensitivity of human oral tumours to the flavonol, morin, during cancer progression: involvement of the Akt and stress kinase pathways Carcinogenesis, February 1, 2003; 24(2): 171 - 177. [Abstract] [Full Text] [PDF]

				K. E. Gordon, H. Ireland, M. Roberts, K. Steeghs, J. A. McCaul, D. G. MacDonald, and E. K. Parkinson High Levels of Telomere Dysfunction Bestow a Selective Disadvantage During the Progression of Human Oral Squamous Cell Carcinoma Cancer Res., January 15, 2003; 63(2): 458 - 467. [Abstract] [Full Text] [PDF]

				F. McGregor, A. Muntoni, J. Fleming, J. Brown, D. H. Felix, D. G. MacDonald, E. K. Parkinson, and P. R. Harrison Molecular Changes Associated with Oral Dysplasia Progression and Acquisition of Immortality: Potential for Its Reversal by 5-Azacytidine Cancer Res., August 15, 2002; 62(16): 4757 - 4766. [Abstract] [Full Text] [PDF]

				A. Ghose, J. Fleming, K. El-Bayoumy, and P. R. Harrison Enhanced Sensitivity of Human Oral Carcinomas to Induction of Apoptosis by Selenium Compounds: Involvement of Mitogen-activated Protein Kinase and Fas Pathways Cancer Res., October 1, 2001; 61(20): 7479 - 7487. [Abstract] [Full Text] [PDF]

				N. Akutsu, R. Lin, Y. Bastien, A. Bestawros, D. J. Enepekides, M. J. Black, and J. H. White Regulation of Gene Expression by 1{{alpha}},25-Dihydroxyvitamin D3 and Its Analog EB1089 under Growth-Inhibitory Conditions in Squamous Carcinoma Cells Mol. Endocrinol., July 1, 2001; 15(7): 1127 - 1139. [Abstract] [Full Text] [PDF]

				X. Guo, D. M Nanus, A. Ruiz, R. R Rando, D. Bok, and L. J Gudas Reduced Levels of Retinyl Esters and Vitamin A in Human Renal Cancers Cancer Res., March 1, 2001; 61(6): 2774 - 2781. [Abstract] [Full Text]

				R. A. Finch, J. Li, T-C. Chou, and A. C. Sartorelli Maintenance of retinoic acid receptor alpha pools by granulocyte colony-stimulating factor and lithium chloride in all-trans retinoic acid-treated WEHI-3B leukemia cells: relevance to the synergistic induction of terminal differentiation Blood, September 15, 2000; 96(6): 2262 - 2268. [Abstract] [Full Text] [PDF]

				T. N. Faria, C. Mendelsohn, P. Chambon, and L. J. Gudas The Targeted Disruption of Both Alleles of RARbeta 2 in F9 Cells Results in the Loss of Retinoic Acid-associated Growth Arrest J. Biol. Chem., September 17, 1999; 274(38): 26783 - 26788. [Abstract] [Full Text] [PDF]