This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bjørge, T. Articles by Dillner, J. Search for Related Content PubMed PubMed Citation Articles by Bjørge, T. Articles by Dillner, J.

A Prospective, Seroepidemiological Study of the Role of Human Papillomavirus in Esophageal Cancer in Norway¹

Cancer Registry of Norway, Institute for Epidemiological Cancer Research, Montebello, N-0310 Oslo, Norway [T. B., A. E., S. T.]; Department of Gynecologic Oncology, The Norwegian Radium Hospital, 0310 Oslo, Norway [T. B.]; Microbiology and Tumorbiology Centre, Karolinska Institute, 17177 Stockholm, Sweden [Z. W., J. D.]; Department of Infectious Disease Epidemiology, National Public Health Institute, 00300 Helsinki, Finland [M. L., J. D.]; National Public Health Institute, 90101 Oulu, Finland [P. K.]; Department of Public Health, University of Helsinki, 00014 Helsinki, Finland [T. H.]; Janus Committee, Norwegian Cancer Society, 0369 Oslo, Norway [E. J.]; Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, 00170 Helsinki, Finland [T. L.]; Department of Obstetrics and Gynecology, Helsinki University Hospital, 00290 Helsinki, Finland [J. P.]; Department of Medical Microbiology, University of Mainz, 55101 Mainz. Germany [M. S.]; Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, Maryland 20892 [J. S.]; and Clinical Trial Service Unit, University of Oxford, Oxford, OX2 6HE, United Kingdom [L. Y.]

Infection with the human papillomavirus (HPV), notably HPV type 16, has been associated with esophageal cancer in seroepidemiological studies. To evaluate the consistency of the association, we performed a nested case-control study of HPV seropositivity and risk of esophageal cancer within a prospectively followed cohort of 300,000 Norwegian men and women who had donated blood samples to a serum bank. The data file of the serum bank was linked with the nationwide Cancer Registry of Norway to identify esophageal cancers diagnosed after donation of the serum sample. Fifty-seven cases and 171 matched controls were analyzed for antibodies to specific microorganisms, and odds ratios for developing esophageal cancer were calculated. There was an increased risk of developing esophageal cancer among HPV 16-seropositive subjects (odds ratio = 6.6; 95% confidence interval, 1.1–71) but not among Chlamydia trachomatis-seropositive subjects. Adjustment for the presence of serum cotinine, a marker of smoking habits, did not affect the estimates substantially. The seroepidemiological association between HPV 16 and esophageal cancer seems to be consistent in different countries.

¹ This work was supported by the Nordic Cancer Union, the Norwegian Cancer Society, the Nordic Council on Research Education, and the Swedish Cancer Society.

² To whom requests for reprints should be addressed, at Cancer Registry of Norway, Institute for Epidemiological Cancer Research, Montebello, N-0310 Oslo, Norway.

Received 3/21/97. Accepted 7/11/97.

This article has been cited by other articles:

				A. S. Kapeu, T. Luostarinen, E. Jellum, J. Dillner, M. Hakama, P. Koskela, P. Lenner, A. Love, E. Mahlamaki, S. Thoresen, et al. Is Smoking an Independent Risk Factor for Invasive Cervical Cancer? A Nested Case-Control Study Within Nordic Biobanks Am. J. Epidemiol., February 15, 2009; 169(4): 480 - 488. [Abstract] [Full Text] [PDF]

				P. Brennan, S. Lewis, M. Hashibe, D. A. Bell, P. Boffetta, C. Bouchardy, N. Caporaso, C. Chen, C. Coutelle, S. R. Diehl, et al. Pooled Analysis of Alcohol Dehydrogenase Genotypes and Head and Neck Cancer: A HuGE Review Am. J. Epidemiol., January 1, 2004; 159(1): 1 - 16. [Abstract] [Full Text] [PDF]

				H.-O. Adami, H. Kuper, S.-O. Andersson, R. Bergstrom, and J. Dillner Prostate Cancer Risk and Serologic Evidence of Human Papilloma Virus Infection: A Population-based Case-Control Study Cancer Epidemiol. Biomarkers Prev., September 1, 2003; 12(9): 872 - 875. [Abstract] [Full Text] [PDF]

				M. L. Gillison and K. V. Shah Chapter 9: Role of Mucosal Human Papillomavirus in Nongenital Cancers J Natl Cancer Inst Monographs, June 1, 2003; 2003(31): 57 - 65. [Abstract] [Full Text] [PDF]

				K J Syrjanen HPV infections and oesophageal cancer J. Clin. Pathol., October 1, 2002; 55(10): 721 - 728. [Abstract] [Full Text] [PDF]

				J. Mork, A. K. Lie, E. Glattre, S. Clark, G. Hallmans, E. Jellum, P. Koskela, B. Moller, E. Pukkala, J. T. Schiller, et al. Human Papillomavirus Infection as a Risk Factor for Squamous-Cell Carcinoma of the Head and Neck N. Engl. J. Med., April 12, 2001; 344(15): 1125 - 1131. [Abstract] [Full Text] [PDF]

				L. Morris Brown, R. Hoover, D. Silverman, D. Baris, R. Hayes, G. M. Swanson, J. Schoenberg, R. Greenberg, J. Liff, A. Schwartz, et al. Excess Incidence of Squamous Cell Esophageal Cancer among US Black Men: Role of Social Class and Other Risk Factors Am. J. Epidemiol., January 15, 2001; 153(2): 114 - 122. [Abstract] [Full Text] [PDF]

				J. Lagergren, Z. Wang, R. Bergstrom, J. Dillner, and O. Nyren Human Papillomavirus Infection and Esophageal Cancer: a Nationwide Seroepidemiologic Case-Control Study in Sweden J Natl Cancer Inst, January 20, 1999; 91(2): 156 - 162. [Abstract] [Full Text] [PDF]