| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Department of Pathology, University of Liverpool, Royal Liverpool University Hospital, Liverpool L69 3GA, United Kingdom
We have analyzed 60 low-grade cervical squamous intraepithelial lesions for low- and high-risk human papillomaviruses (HPVs) and for numerical abnormalities of chromosomes 1, 3, 11, 17, and 18 and the X chromosome. Eleven of 33 lesions infected with high-risk HPVs (HPV 16, 18, 30, 31, 33, 35, 39, 45, 51, 52, 56, 58, and 66) but none of 24 lesions infected with low-risk HPVs (HPV 6, 11, 42, 43, and 44) and none of 15 normal cervices showed basal cell tetrasomy of all six chromosomes in the HPV-infected areas. These changes were not HPV type specific and were not present in all lesions infected with the same HPV type. The presence of basal cell tetrasomy in lesions infected with high- but not low-risk HPVs suggests that induction of chromosome instability may be one mechanism underlying the biological differences between these viral types.
1 This work was supported by grants from Wellbeing and the Royal College of Obstetricians and Gynaecologists (H1/96) and the University of Liverpool.
2 To whom requests for reprints should be addressed. Phone: 44-151-706-4106; Fax: 44-151-706-5859; E-mail: c.s.herrington@liv.ac.uk.
Received 7/17/97. Accepted 8/18/97.
This article has been cited by other articles:
|
|
 |
|
  D. van Hamont, J. Bulten, H. Shirango, W.J.G. Melchers, L.F.A.G. Massuger, and P.C.M. de Wilde Biological behavior of CIN lesions is predictable by multiple parameter logistic regression models Carcinogenesis, April 1, 2008; 29(4): 840 - 845. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Olaharski, R. Sotelo, G. Solorza-Luna, M. E. Gonsebatt, P. Guzman, A. Mohar, and D. A. Eastmond Tetraploidy and chromosomal instability are early events during cervical carcinogenesis Carcinogenesis, February 1, 2006; 27(2): 337 - 343. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.C. Reshmi and S.M. Gollin Chromosomal Instability in Oral Cancer Cells J. Dent. Res., February 1, 2005; 84(2): 107 - 117. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Duensing and K. Munger The Human Papillomavirus Type 16 E6 and E7 Oncoproteins Independently Induce Numerical and Structural Chromosome Instability Cancer Res., December 1, 2002; 62(23): 7075 - 7082. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M J Gallagher, A Giannoudis, C S Herrington, and P Hiscott Human papillomavirus in pterygium Br. J. Ophthalmol., July 1, 2001; 85(7): 782 - 784. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C S Herrington, M Worsham, S A Southern, P Mackowiak, and S R Wolman Loss of sequences on the short arm of chromosome 17 is a late event in squamous carcinoma of the cervix Mol. Pathol., June 1, 2001; 54(3): 160 - 164. [Abstract] [Full Text]
|
|
|
|
|
|
S. A. Southern, F. Noya, C. Meyers, T. R. Broker, L. T. Chow, and C. S. Herrington Tetrasomy Is Induced by Human Papillomavirus Type 18 E7 Gene Expression in Keratinocyte Raft Cultures Cancer Res., June 1, 2001; 61(12): 4858 - 4863. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D A Graham and C S Herrington HPV-16 E2 gene disruption and sequence variation in CIN 3 lesions and invasive squamous cell carcinomas of the cervix: relation to numerical chromosome abnormalities Mol. Pathol., August 1, 2000; 53(4): 201 - 206. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Cell Growth & Differentiation |
