Cancer Research AACR Membership  Genetics and Biology of Brain Cancer
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online

[Cancer Research 57, 4285-4300, October 1, 1997]
© 1997 American Association for Cancer Research

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by O'Connor, P. M.
Right arrow Articles by Kohn, K. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by O'Connor, P. M.
Right arrow Articles by Kohn, K. W.

Characterization of the p53 Tumor Suppressor Pathway in Cell Lines of the National Cancer Institute Anticancer Drug Screen and Correlations with the Growth-Inhibitory Potency of 123 Anticancer Agents

Patrick M. O'Connor1, Joany Jackman, Insoo Bae, Timothy G. Myers, Saijun Fan, Masato Mutoh, Dominic A. Scudiero, Ann Monks, Edward A. Sausville, John N. Weinstein, Stephen Friend, Albert J. Fornace, Jr. and Kurt W. Kohn

Laboratory of Molecular Pharmacology, Division of Basic Sciences, National Cancer Institute, NIH, Bethesda, Maryland 20892 [P. M. O., J. J., I. B., T. G. M., S. Fa., M. M., J. N. W., A. J. F., K. W. K.]; Developmental Therapeutics Program, National Cancer Institute, Frederick Cancer Research & Development Center, Frederick, Maryland 21702 [D. A. S., A. M., E. A. S.]; and Laboratory of Molecular Pharmacology, Fred Hutchinson Cancer Center, Seattle, Washington 98104 [S. Fr.]

In the present study, we report the characterization of the p53 tumor suppressor pathway in the 60 cell lines of the National Cancer Institute (NCI) anticancer drug screen, as well as correlations between the integrity of this pathway and the growth-inhibitory potency of 123 anticancer agents in this screen. Assessment of p53 status in these lines was achieved through complete p53 cDNA sequencing, measurement of basal p53 protein levels and functional assessment of (a) transcriptional activity of p53 cDNA from each line in a yeast assay, (b) {gamma}-ray-induced G1 phase cell cycle arrest, and (c) {gamma}-ray-induced expression of CIP1/WAF1, GADD45, and MDM2 mRNA. Our investigations revealed that p53 gene mutations were common in the NCI cell screen lines: 39 of 58 cell lines analyzed contained a mutant p53 sequence. cDNA derived from almost all of the mutant p53 cell lines failed to transcriptionally activate a reporter gene in yeast, and the majority of mutant p53 lines studied expressed elevated basal levels of the mutant p53 protein. In contrast to most of the wild-type p53-containing lines, cells containing mutant p53 sequence were also deficient in {gamma}-ray induction of CIP1/WAF1, GADD45, and MDM2 mRNA and the ability to arrest in G1 following {gamma}-irradiation. Taken together, these assessments provided indications of the integrity of the p53 pathway in the 60 cell lines of the NCI cell screen. These individual p53 assessments were subsequently used to probe a database of growth-inhibitory potency for 123 "standard agents," which included the majority of clinically approved anticancer drugs. These 123 agents have been tested against these lines on multiple occasions, and a proposed mechanism of drug action had previously been assigned to each agent. Our analysis revealed that cells with mutant p53 sequence tended to exhibit less growth inhibition in this screen than the wild-type p53 cell lines when treated with the majority of clinically used anticancer agents: including DNA cross-linking agents, antimetabolites, and topoisomerase I and II inhibitors. Similar correlations were uncovered when we probed this database using most of the other indices of p53 status we assessed in the lines. Interestingly, a class of agents that differed in this respect was the antimitotic agents. Growth-inhibitory activity of these agents tended, in this assay, to be independent of p53 status. Our characterization of the p53 pathway in the NCI cell screen lines should prove useful to researchers investigating fundamental aspects of p53 biology and pharmacology. This information also allows for the large-scale analysis of the more than 60,000 compounds tested against these lines for novel agents that might exploit defective p53 function as a means of preferential toxicity.

1 To whom requests for reprints should be addressed, at Laboratory of Molecular Pharmacology, Division of Basic Science, Building 37, Room 5C25, National Cancer Institute, NIH, Bethesda, MD 20892. Phone: (301) 435-2848; Fax: (301) 402-0752; E-mail: oconnorp@dc37a.nci.nih.gov.

Received 4/25/97. Accepted 7/25/97.




This article has been cited by other articles:


Home page
Mol. Pharmacol.Home page
J. F. Deeken, R. W. Robey, S. Shukla, K. Steadman, A. R. Chakraborty, B. Poonkuzhali, E. G. Schuetz, S. Holbeck, S. V. Ambudkar, and S. E. Bates
Identification of Compounds that Correlate with ABCG2 Transporter Function in the National Cancer Institute Anticancer Drug Screen
Mol. Pharmacol., November 1, 2009; 76(5): 946 - 956.
[Abstract] [Full Text] [PDF]


Home page
Molecular Cancer TherapeuticsHome page
N. F. Krynetskaia, M. S. Phadke, S. H. Jadhav, and E. Y. Krynetskiy
Chromatin-associated proteins HMGB1/2 and PDIA3 trigger cellular response to chemotherapy-induced DNA damage
Mol. Cancer Ther., April 1, 2009; 8(4): 864 - 872.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
K. H. Young, K. Leroy, M. B. Moller, G. W. B. Colleoni, M. Sanchez-Beato, F. R. Kerbauy, C. Haioun, J. C. Eickhoff, A. H. Young, P. Gaulard, et al.
Structural profiles of TP53 gene mutations predict clinical outcome in diffuse large B-cell lymphoma: an international collaborative study
Blood, October 15, 2008; 112(8): 3088 - 3098.
[Abstract] [Full Text] [PDF]


Home page
Molecular Cancer TherapeuticsHome page
J. Kitagaki, K. K. Agama, Y. Pommier, Y. Yang, and A. M. Weissman
Targeting tumor cells expressing p53 with a water-soluble inhibitor of Hdm2
Mol. Cancer Ther., August 1, 2008; 7(8): 2445 - 2454.
[Abstract] [Full Text] [PDF]


Home page
Ann OncolHome page
F.-C. Bidard, M.-C. Matthieu, P. Chollet, I. Raoefils, C. Abrial, J. Domont, M. Spielmann, S. Delaloge, F. Andre, and F. Penault-Llorca
p53 status and efficacy of primary anthracyclines/alkylating agent-based regimen according to breast cancer molecular classes
Ann. Onc., July 1, 2008; 19(7): 1261 - 1265.
[Abstract] [Full Text] [PDF]


Home page
ThoraxHome page
S Mohamed, K Yasufuku, T Nakajima, K Hiroshima, R Kubo, A Iyoda, S Yoshida, M Suzuki, Y Sekine, K Shibuya, et al.
Analysis of cell cycle-related proteins in mediastinal lymph nodes of patients with N2-NSCLC obtained by EBUS-TBNA: relevance to chemotherapy response
Thorax, July 1, 2008; 63(7): 642 - 647.
[Abstract] [Full Text] [PDF]


Home page
Molecular Cancer TherapeuticsHome page
O. N. Ikediobi, M. Reimers, S. Durinck, P. E. Blower, A. P. Futreal, M. R. Stratton, and J. N. Weinstein
In vitro differential sensitivity of melanomas to phenothiazines is based on the presence of codon 600 BRAF mutation
Mol. Cancer Ther., June 1, 2008; 7(6): 1337 - 1346.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
Y. Li, F. Guessous, S. Kwon, M. Kumar, O. Ibidapo, L. Fuller, E. Johnson, B. Lal, I. Hussaini, Y. Bao, et al.
PTEN Has Tumor-Promoting Properties in the Setting of Gain-of-Function p53 Mutations
Cancer Res., March 15, 2008; 68(6): 1723 - 1731.
[Abstract] [Full Text] [PDF]


Home page
J. Cell Sci.Home page
A. Astanehe, D. Arenillas, W. W. Wasserman, P. C. K. Leung, S. E. Dunn, B. R. Davies, G. B. Mills, and N. Auersperg
Mechanisms underlying p53 regulation of PIK3CA transcription in ovarian surface epithelium and in ovarian cancer
J. Cell Sci., March 1, 2008; 121(5): 664 - 674.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
S. Bottger, E. Jerszyk, B. Low, and C. Walker
Genotoxic Stress-Induced Expression of p53 and Apoptosis in Leukemic Clam Hemocytes with Cytoplasmically Sequestered p53
Cancer Res., February 1, 2008; 68(3): 777 - 782.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
S. A. Amundson, K. T. Do, L. C. Vinikoor, R. A. Lee, C. A. Koch-Paiz, J. Ahn, M. Reimers, Y. Chen, D. A. Scudiero, J. N. Weinstein, et al.
Integrating Global Gene Expression and Radiation Survival Parameters across the 60 Cell Lines of the National Cancer Institute Anticancer Drug Screen
Cancer Res., January 15, 2008; 68(2): 415 - 424.
[Abstract] [Full Text] [PDF]


Home page
Nucleic Acids ResHome page
S. Renaud, E. M. Pugacheva, M. D. Delgado, R. Braunschweig, Z. Abdullaev, D. Loukinov, J. Benhattar, and V. Lobanenkov
Expression of the CTCF-paralogous cancer-testis gene, brother of the regulator of imprinted sites (BORIS), is regulated by three alternative promoters modulated by CpG methylation and by CTCF and p53 transcription factors
Nucleic Acids Res., December 18, 2007; 35(21): 7372 - 7388.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. ProteomicsHome page
L. M. Orre, M. Pernemalm, J. Lengqvist, R. Lewensohn, and J. Lehtio
Up-regulation, Modification, and Translocation of S100A6 Induced by Exposure to Ionizing Radiation Revealed by Proteomics Profiling
Mol. Cell. Proteomics, December 1, 2007; 6(12): 2122 - 2131.
[Abstract] [Full Text] [PDF]


Home page
JCOHome page
O. Riesterer, L. Milas, and K. K. Ang
Use of Molecular Biomarkers for Predicting the Response to Radiotherapy With or Without Chemotherapy
J. Clin. Oncol., September 10, 2007; 25(26): 4075 - 4083.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
M. S. Nayak, J.-M. Yang, and W. N. Hait
Effect of a Single Nucleotide Polymorphism in the Murine Double Minute 2 Promoter (SNP309) on the Sensitivity to Topoisomerase II-Targeting Drugs
Cancer Res., June 15, 2007; 67(12): 5831 - 5839.
[Abstract] [Full Text] [PDF]


Home page
Ann OncolHome page
A Di Leo, M Tanner, C Desmedt, M Paesmans, F Cardoso, V Durbecq, S Chan, T Perren, M Aapro, C Sotiriou, et al.
p-53 gene mutations as a predictive marker in a population of advanced breast cancer patients randomly treated with doxorubicin or docetaxel in the context of a phase III clinical trial
Ann. Onc., June 1, 2007; 18(6): 997 - 1003.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
M.-H. Tsai, J. A. Cook, G. V.R. Chandramouli, W. DeGraff, H. Yan, S. Zhao, C. N. Coleman, J. B. Mitchell, and E. Y. Chuang
Gene Expression Profiling of Breast, Prostate, and Glioma Cells following Single versus Fractionated Doses of Radiation
Cancer Res., April 15, 2007; 67(8): 3845 - 3852.
[Abstract] [Full Text] [PDF]


Home page
Molecular Cancer TherapeuticsHome page
D. Wilsker and F. Bunz
Loss of ataxia telangiectasia mutated- and Rad3-related function potentiates the effects of chemotherapeutic drugs on cancer cell survival
Mol. Cancer Ther., April 1, 2007; 6(4): 1406 - 1413.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
A. Jalota-Badhwar, R. Kaul-Ghanekar, D. Mogare, R. Boppana, K. M. Paknikar, and S. Chattopadhyay
SMAR1-derived P44 Peptide Retains Its Tumor Suppressor Function through Modulation of p53
J. Biol. Chem., March 30, 2007; 282(13): 9902 - 9913.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
X.-X. Sun, M.-S. Dai, and H. Lu
5-Fluorouracil Activation of p53 Involves an MDM2-Ribosomal Protein Interaction
J. Biol. Chem., March 16, 2007; 282(11): 8052 - 8059.
[Abstract] [Full Text] [PDF]


Home page
CarcinogenesisHome page
A. A. Levesque and A. Eastman
p53-based cancer therapies: is defective p53 the Achilles heel of the tumor?
Carcinogenesis, January 1, 2007; 28(1): 13 - 20.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
M. L. Fishel, Y. He, M. L. Smith, and M. R. Kelley
Manipulation of Base Excision Repair to Sensitize Ovarian Cancer Cells to Alkylating Agent Temozolomide
Clin. Cancer Res., January 1, 2007; 13(1): 260 - 267.
[Abstract] [Full Text] [PDF]


Home page
Molecular Cancer TherapeuticsHome page
O. N. Ikediobi, H. Davies, G. Bignell, S. Edkins, C. Stevens, S. O'Meara, T. Santarius, T. Avis, S. Barthorpe, L. Brackenbury, et al.
Mutation analysis of 24 known cancer genes in the NCI-60 cell line set
Mol. Cancer Ther., November 1, 2006; 5(11): 2606 - 2612.
[Abstract] [Full Text] [PDF]


Home page
Molecular Cancer TherapeuticsHome page
P. L. Lorenzi, W. C. Reinhold, M. Rudelius, M. Gunsior, U. Shankavaram, K. J. Bussey, U. Scherf, G. S. Eichler, S. E. Martin, K. Chin, et al.
Asparagine synthetase as a causal, predictive biomarker for L-asparaginase activity in ovarian cancer cells
Mol. Cancer Ther., November 1, 2006; 5(11): 2613 - 2623.
[Abstract] [Full Text] [PDF]


Home page
Molecular Cancer TherapeuticsHome page
J. N. Weinstein
Spotlight on molecular profiling: "Integromic" analysis of the NCI-60 cancer cell lines
Mol. Cancer Ther., November 1, 2006; 5(11): 2601 - 2605.
[Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
M. Whitnall, J. Howard, P. Ponka, and D. R. Richardson
A class of iron chelators with a wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics
PNAS, October 3, 2006; 103(40): 14901 - 14906.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
A. R. Shoemaker, A. Oleksijew, J. Bauch, B. A. Belli, T. Borre, M. Bruncko, T. Deckwirth, D. J. Frost, K. Jarvis, M. K. Joseph, et al.
A Small-Molecule Inhibitor of Bcl-XL Potentiates the Activity of Cytotoxic Drugs In vitro and In vivo.
Cancer Res., September 1, 2006; 66(17): 8731 - 8739.
[Abstract] [Full Text] [PDF]


Home page
CarcinogenesisHome page
A. Calcabrini, J. M. Garcia-Martinez, L. Gonzalez, M. J. Tendero, M. T. A. Ortuno, P. Crateri, A. Lopez-Rivas, G. Arancia, P. Gonzalez-Porque, and J. Martin-Perez
Inhibition of proliferation and induction of apoptosis in human breast cancer cells by lauryl gallate
Carcinogenesis, August 1, 2006; 27(8): 1699 - 1712.
[Abstract] [Full Text] [PDF]


Home page
Endocr Relat CancerHome page
M. Lacroix, R.-A. Toillon, and G. Leclercq
p53 and breast cancer, an update.
Endocr. Relat. Cancer, June 1, 2006; 13(2): 293 - 325.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
M. Olivier, A. Langerod, P. Carrieri, J. Bergh, S. Klaar, J. Eyfjord, C. Theillet, C. Rodriguez, R. Lidereau, I. Bieche, et al.
The Clinical Value of Somatic TP53 Gene Mutations in 1,794 Patients with Breast Cancer
Clin. Cancer Res., February 15, 2006; 12(4): 1157 - 1167.
[Abstract] [Full Text] [PDF]


Home page
Mol. Pharmacol.Home page
A. L. Harris, J. J. Ryan, and N. Farrell
Biological Consequences of Trinuclear Platinum Complexes: Comparison of [{trans-PtCl(NH3)2}2{micro}-(trans-Pt(NH3)2(H2N(CH2)6-NH2)2)]4+ (BBR 3464) with Its Noncovalent Congeners
Mol. Pharmacol., February 1, 2006; 69(2): 666 - 672.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
J. Turner, C. Koumenis, T. E. Kute, R. P. Planalp, M. W. Brechbiel, D. Beardsley, B. Cody, K. D. Brown, F. M. Torti, and S. V. Torti
Tachpyridine, a metal chelator, induces G2 cell-cycle arrest, activates checkpoint kinases, and sensitizes cells to ionizing radiation
Blood, November 1, 2005; 106(9): 3191 - 3199.
[Abstract] [Full Text] [PDF]


Home page
Molecular Cancer TherapeuticsHome page
M. I. Walton, S. C. Wilson, I. R. Hardcastle, A. R. Mirza, and P. Workman
An evaluation of the ability of pifithrin-{alpha} and -{beta} to inhibit p53 function in two wild-type p53 human tumor cell lines
Mol. Cancer Ther., September 1, 2005; 4(9): 1369 - 1377.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
F. Rodel, J. Hoffmann, L. Distel, M. Herrmann, T. Noisternig, T. Papadopoulos, R. Sauer, and C. Rodel
Survivin as a Radioresistance Factor, and Prognostic and Therapeutic Target for Radiotherapy in Rectal Cancer
Cancer Res., June 1, 2005; 65(11): 4881 - 4887.
[Abstract] [Full Text] [PDF]


Home page
Molecular Cancer TherapeuticsHome page
Y. Li, Y. Mao, P. W. Brandt-Rauf, A. C. Williams, and R. L. Fine
Selective induction of apoptosis in mutant p53 premalignant and malignant cancer cells by PRIMA-1 through the c-Jun-NH2-kinase pathway
Mol. Cancer Ther., June 1, 2005; 4(6): 901 - 909.
[Abstract] [Full Text] [PDF]


Home page
JNCI J Natl Cancer InstHome page
T. Mashima, T. Oh-hara, S. Sato, M. Mochizuki, Y. Sugimoto, K. Yamazaki, J.-i. Hamada, M. Tada, T. Moriuchi, Y. Ishikawa, et al.
p53-Defective Tumors With a Functional Apoptosome-Mediated Pathway: A New Therapeutic Target
J Natl Cancer Inst, May 18, 2005; 97(10): 765 - 777.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
L. Rambhatla, S. Ram-Mohan, J. J. Cheng, and J. L. Sherley
Immortal DNA Strand Cosegregation Requires p53/IMPDH-Dependent Asymmetric Self-renewal Associated with Adult Stem Cells
Cancer Res., April 15, 2005; 65(8): 3155 - 3161.
[Abstract] [Full Text] [PDF]


Home page
BioinformaticsHome page
R. Pal, A. Datta, A. J. Fornace Jr, M. L. Bittner, and E. R. Dougherty
Boolean relationships among genes responsive to ionizing radiation in the NCI 60 ACDS
Bioinformatics, April 15, 2005; 21(8): 1542 - 1549.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
Z. Liu, K.-R. Muehlbauer, H. H. Schmeiser, M. Hergenhahn, D. Belharazem, and M. C. Hollstein
p53 Mutations in Benzo(a)Pyrene-Exposed Human p53 Knock-in Murine Fibroblasts Correlate with p53 Mutations in Human Lung Tumors
Cancer Res., April 1, 2005; 65(7): 2583 - 2587.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
M. Tokumo, S. Toyooka, K. Kiura, H. Shigematsu, K. Tomii, M. Aoe, K. Ichimura, T. Tsuda, M. Yano, K. Tsukuda, et al.
The Relationship between Epidermal Growth Factor Receptor Mutations and Clinicopathologic Features in Non-Small Cell Lung Cancers
Clin. Cancer Res., February 1, 2005; 11(3): 1167 - 1173.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
L.-h. Meng, H. Zhang, L. Hayward, H. Takemura, R.-G. Shao, and Y. Pommier
Tetrandrine Induces Early G1 Arrest in Human Colon Carcinoma Cells by Down-Regulating the Activity and Inducing the Degradation of G1-S-Specific Cyclin-Dependent Kinases and by Inducing p53 and p21Cip1
Cancer Res., December 15, 2004; 64(24): 9086 - 9092.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
S. Kim, K. Chin, J. W. Gray, and J. M. Bishop
A screen for genes that suppress loss of contact inhibition: Identification of ING4 as a candidate tumor suppressor gene in human cancer
PNAS, November 16, 2004; 101(46): 16251 - 16256.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
P. A. Svingen, D. Loegering, J. Rodriquez, X. W. Meng, P. W. Mesner Jr., S. Holbeck, A. Monks, S. Krajewski, D. A. Scudiero, E. A. Sausville, et al.
Components of the Cell Death Machine and Drug Sensitivity of the National Cancer Institute Cell Line Panel
Clin. Cancer Res., October 15, 2004; 10(20): 6807 - 6820.
[Abstract] [Full Text] [PDF]


Home page
Nucleic Acids ResHome page
J. Kasparkova, M. Fojta, N. Farrell, and V. Brabec
Differential recognition by the tumor suppressor protein p53 of DNA modified by the novel antitumor trinuclear platinum drug BBR3464 and cisplatin
Nucleic Acids Res., October 14, 2004; 32(18): 5546 - 5552.
[Abstract] [Full Text] [PDF]


Home page
Molecular Cancer TherapeuticsHome page
V. Durbecq, M. Paesmans, F. Cardoso, C. Desmedt, A. Di Leo, S. Chan, K. Friedrichs, T. Pinter, S. Van Belle, E. Murray, et al.
Topoisomerase-II{alpha} expression as a predictive marker in a population of advanced breast cancer patients randomly treated either with single-agent doxorubicin or single-agent docetaxel
Mol. Cancer Ther., October 1, 2004; 3(10): 1207 - 1214.
[Abstract] [Full Text] [PDF]


Home page
Nucleic Acids ResHome page
T. Shiraishi and P. E. Nielsen
Down-regulation of MDM2 and activation of p53 in human cancer cells by antisense 9-aminoacridine-PNA (peptide nucleic acid) conjugates
Nucleic Acids Res., September 15, 2004; 32(16): 4893 - 4902.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
J. Lin, Q. Yang, Z. Yan, J. Markowitz, P. T. Wilder, F. Carrier, and D. J. Weber
Inhibiting S100B Restores p53 Levels in Primary Malignant Melanoma Cancer Cells
J. Biol. Chem., August 6, 2004; 279(32): 34071 - 34077.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
K. Nakayama, A. Kanzaki, K. Terada, M. Mutoh, K. Ogawa, T. Sugiyama, S. Takenoshita, K. Itoh, N. Yaegashi, K. Miyazaki, et al.
Prognostic Value of the Cu-Transporting ATPase in Ovarian Carcinoma Patients Receiving Cisplatin-Based Chemotherapy
Clin. Cancer Res., April 15, 2004; 10(8): 2804 - 2811.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
Z. Liu, M. Hergenhahn, H. H. Schmeiser, G. N. Wogan, A. Hong, and M. Hollstein
Human tumor p53 mutations are selected for in mouse embryonic fibroblasts harboring a humanized p53 gene
PNAS, March 2, 2004; 101(9): 2963 - 2968.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
N. J. Curtin, L.-Z. Wang, A. Yiakouvaki, S. Kyle, C. A. Arris, S. Canan-Koch, S. E. Webber, B. W. Durkacz, H. A. Calvert, Z. Hostomsky, et al.
Novel Poly(ADP-ribose) Polymerase-1 Inhibitor, AG14361, Restores Sensitivity to Temozolomide in Mismatch Repair-Deficient Cells
Clin. Cancer Res., February 1, 2004; 10(3): 881 - 889.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
H. Chen, S. Chung, and S. Sukumar
HOXA5-Induced Apoptosis in Breast Cancer Cells Is Mediated by Caspases 2 and 8
Mol. Cell. Biol., January 15, 2004; 24(2): 924 - 935.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
A. Vekris, D. Meynard, M.-C. Haaz, M. Bayssas, J. Bonnet, and J. Robert
Molecular Determinants of the Cytotoxicity of Platinum Compounds: The Contribution of in Silico Research
Cancer Res., January 1, 2004; 64(1): 356 - 362.
[Abstract] [Full Text] [PDF]


Home page
Molecular Cancer TherapeuticsHome page
D. S. Sappal, A. K. McClendon, J. A. Fleming, V. Thoroddsen, K. Connolly, C. Reimer, R. K. Blackman, C. E. Bulawa, N. Osheroff, P. Charlton, et al.
Biological characterization of MLN944: A potent DNA binding agent
Mol. Cancer Ther., January 1, 2004; 3(1): 47 - 58.
[Abstract] [Full Text]


Home page
Proc. Natl. Acad. Sci. USAHome page
C. A. Kanashiro, A. V. Schally, K. Groot, P. Armatis, A. L. F. Bernardino, and J. L. Varga
Inhibition of mutant p53 expression and growth of DMS-153 small cell lung carcinoma by antagonists of growth hormone-releasing hormone and bombesin
PNAS, December 23, 2003; 100(26): 15836 - 15841.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
A. V. Roschke, G. Tonon, K. S. Gehlhaus, N. McTyre, K. J. Bussey, S. Lababidi, D. A. Scudiero, J. N. Weinstein, and I. R. Kirsch
Karyotypic Complexity of the NCI-60 Drug-Screening Panel
Cancer Res., December 15, 2003; 63(24): 8634 - 8647.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
J. M. Mariadason, D. Arango, Q. Shi, A. J. Wilson, G. A. Corner, C. Nicholas, M. J. Aranes, M. Lesser, E. L. Schwartz, and L. H. Augenlicht
Gene Expression Profiling-Based Prediction of Response of Colon Carcinoma Cells to 5-Fluorouracil and Camptothecin
Cancer Res., December 15, 2003; 63(24): 8791 - 8812.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
J. L. Bronder and R. G. Moran
A Defect in the p53 Response Pathway Induced by de Novo Purine Synthesis Inhibition
J. Biol. Chem., December 5, 2003; 278(49): 48861 - 48871.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
X. Wu, W. Fan, S. Xu, and Y. Zhou
Sensitization to the Cytotoxicity of Cisplatin by Transfection with Nucleotide Excision Repair Gene Xeroderma Pigmentosun Group A Antisense RNA in Human Lung Adenocarcinoma Cells
Clin. Cancer Res., December 1, 2003; 9(16): 5874 - 5879.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
M. S. Kim, M. Blake, J. H. Baek, G. Kohlhagen, Y. Pommier, and F. Carrier
Inhibition of Histone Deacetylase Increases Cytotoxicity to Anticancer Drugs Targeting DNA
Cancer Res., November 1, 2003; 63(21): 7291 - 7300.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
M. A. C. Pratt, T. E. Bishop, D. White, G. Yasvinski, M. Menard, M. Y. Niu, and R. Clarke
Estrogen Withdrawal-Induced NF-{kappa}B Activity and Bcl-3 Expression in Breast Cancer Cells: Roles in Growth and Hormone Independence
Mol. Cell. Biol., October 1, 2003; 23(19): 6887 - 6900.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
J. S. Russell, W. Burgan, K. A. Oswald, K. Camphausen, and P. J. Tofilon
Enhanced Cell Killing Induced by the Combination of Radiation and the Heat Shock Protein 90 Inhibitor 17-Allylamino-17- Demethoxygeldanamycin: A Multitarget Approach to Radiosensitization
Clin. Cancer Res., September 1, 2003; 9(10): 3749 - 3755.
[Abstract] [Full Text] [PDF]


Home page
Mol. Pharmacol.Home page
T. Efferth, A. Sauerbrey, A. Olbrich, E. Gebhart, P. Rauch, H. O. Weber, J. G. Hengstler, M.-E. Halatsch, M. Volm, K. D. Tew, et al.
Molecular Modes of Action of Artesunate in Tumor Cell Lines
Mol. Pharmacol., August 1, 2003; 64(2): 382 - 394.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
Y. Chen, K. Alm, S. Vujcic, D. L. Kramer, K. Kee, P. Diegelman, and C. W. Porter
The Role of Mitogen-activated Protein Kinase Activation in Determining Cellular Outcomes in Polyamine Analogue-treated Human Melanoma Cells
Cancer Res., July 1, 2003; 63(13): 3619 - 3625.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
V. Poindessous, F. Koeppel, E. Raymond, M. Comisso, S. J. Waters, and A. K. Larsen
Marked Activity of Irofulven toward Human Carcinoma Cells: Comparison with Cisplatin and Ecteinascidin
Clin. Cancer Res., July 1, 2003; 9(7): 2817 - 2825.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
T. L. Tinley, D. A. Randall-Hlubek, R. M. Leal, E. M. Jackson, J. W. Cessac, J. C. Quada Jr., T. K. Hemscheidt, and S. L. Mooberry
Taccalonolides E and A: Plant-derived Steroids with Microtubule-stabilizing Activity
Cancer Res., June 15, 2003; 63(12): 3211 - 3220.
[Abstract] [Full Text] [PDF]


Home page
J Biomol ScreenHome page
K. A. Giuliano
High-Content Profiling of Drug-Drug Interactions: Cellular Targets Involved in the Modulation of Microtubule Drug Action by the Antifungal Ketoconazole
J Biomol Screen, April 1, 2003; 8(2): 125 - 135.
[Abstract] [PDF]


Home page
Cancer Res.Home page
T. L. Tinley, R. M. Leal, D. A. Randall-Hlubek, J. W. Cessac, L. R. Wilkens, P. N. Rao, and S. L. Mooberry
Novel 2-Methoxyestradiol Analogues with Antitumor Activity
Cancer Res., April 1, 2003; 63(7): 1538 - 1549.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
L. Yang, T. Mashima, S. Sato, M. Mochizuki, H. Sakamoto, T. Yamori, T. Oh-hara, and T. Tsuruo
Predominant Suppression of Apoptosome by Inhibitor of Apoptosis Protein in Non-Small Cell Lung Cancer H460 Cells: Therapeutic Effect of a Novel Polyarginine-conjugated Smac Peptide
Cancer Res., February 15, 2003; 63(4): 831 - 837.
[Abstract] [Full Text] [PDF]


Home page
JCOHome page
C. J. Allegra, S. Paik, L. H. Colangelo, A. L. Parr, I. Kirsch, G. Kim, P. Klein, P. G. Johnston, N. Wolmark, and H. S. Wieand
Prognostic Value of Thymidylate Synthase, Ki-67, and p53 in Patients With Dukes' B and C Colon Cancer: A National Cancer Institute-National Surgical Adjuvant Breast and Bowel Project Collaborative Study
J. Clin. Oncol., January 15, 2003; 21(2): 241 - 250.
[Abstract] [Full Text] [PDF]


Home page
J. Pharmacol. Exp. Ther.Home page
P. Russo, D. Arzani, S. Trombino, and C. Falugi
c-myc Down-Regulation Induces Apoptosis in Human Cancer Cell Lines Exposed to RPR-115135 (C31H29NO4), a Non-Peptidomimetic Farnesyltransferase Inhibitor
J. Pharmacol. Exp. Ther., January 1, 2003; 304(1): 37 - 47.
[Abstract] [Full Text] [PDF]


Home page
Molecular Cancer TherapeuticsHome page
S. Yang, J. Chen, Z. Guo, X.-M. Xu, L. Wang, X.-F. Pei, J. Yang, C. B. Underhill, and L. Zhang
Triptolide Inhibits the Growth and Metastasis of Solid Tumors
Mol. Cancer Ther., January 1, 2003; 2(1): 65 - 72.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
S. Bolshakov, C. M. Walker, S. S. Strom, M. S. Selvan, G. L. Clayman, A. El-Naggar, S. M. Lippman, M. L. Kripke, and H. N. Ananthaswamy
p53 Mutations in Human Aggressive and Nonaggressive Basal and Squamous Cell Carcinomas
Clin. Cancer Res., January 1, 2003; 9(1): 228 - 234.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
D. Pati, N. Zhang, and S. E. Plon
Linking Sister Chromatid Cohesion and Apoptosis: Role of Rad21
Mol. Cell. Biol., December 1, 2002; 22(23): 8267 - 8277.
[Abstract] [Full Text] [PDF]


Home page
CarcinogenesisHome page
V. J.N. Bykov, N. Issaeva, G. Selivanova, and K. G. Wiman
Mutant p53-dependent growth suppression distinguishes PRIMA-1 from known anticancer drugs: a statistical analysis of information in the National Cancer Institute database
Carcinogenesis, December 1, 2002; 23(12): 2011 - 2018.
[Abstract] [Full Text] [PDF]


Home page
Molecular Cancer TherapeuticsHome page
S. T. Nawrocki, C. J. Bruns, M. T. Harbison, R. J. Bold, B. S. Gotsch, J. L. Abbruzzese, P. Elliott, J. Adams, and D. J. McConkey
Effects of the Proteasome Inhibitor PS-341 on Apoptosis and Angiogenesis in Orthotopic Human Pancreatic Tumor Xenografts
Mol. Cancer Ther., December 1, 2002; 1(14): 1243 - 1253.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
H. Zhang, X. Shi, Q.-J. Zhang, M. Hampong, H. Paddon, D. Wahyuningsih, and S. Pelech
Nocodazole-induced p53-dependent c-Jun N-terminal Kinase Activation Reduces Apoptosis in Human Colon Carcinoma HCT116 Cells
J. Biol. Chem., November 8, 2002; 277(46): 43648 - 43658.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
V. W. van Beusechem, P. B. van den Doel, J. Grill, H. M. Pinedo, and W. R. Gerritsen
Conditionally Replicative Adenovirus Expressing p53 Exhibits Enhanced Oncolytic Potency
Cancer Res., November 1, 2002; 62(21): 6165 - 6171.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
D.-G. Kim, K.-R. You, M.-J. Liu, Y.-K. Choi, and Y.-S. Won
GADD153-mediated Anticancer Effects of N-(4-Hydroxyphenyl)retinamide on Human Hepatoma Cells
J. Biol. Chem., October 4, 2002; 277(41): 38930 - 38938.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
J. Wen, K.-R. You, S.-Y. Lee, C.-H. Song, and D.-G. Kim
Oxidative Stress-mediated Apoptosis. THE ANTICANCER EFFECT OF THE SESQUITERPENE LACTONE PARTHENOLIDE
J. Biol. Chem., October 4, 2002; 277(41): 38954 - 38964.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
J. L. Bronder and R. G. Moran
Antifolates Targeting Purine Synthesis Allow Entry of Tumor Cells into S Phase Regardless of p53 Function
Cancer Res., September 15, 2002; 62(18): 5236 - 5241.
[Abstract] [Full Text] [PDF]


Home page
Mol. Pharmacol.Home page
J. E. Mullally and F. A. Fitzpatrick
Pharmacophore Model for Novel Inhibitors of Ubiquitin Isopeptidases That Induce p53-Independent Cell Death
Mol. Pharmacol., August 1, 2002; 62(2): 351 - 358.
[Abstract] [Full Text] [PDF]


Home page
Molecular Cancer TherapeuticsHome page
C. Pipaon, P. Gutierrez, J. C. Montero, M. Lorenzo, A. Eguiraun, J. A. De la Fuente, A. Pandiella, J. Leon, and J. M. Ortiz
Mitogen-activated Protein Kinase Routes as Targets in the Action of Diaza-anthracene Compounds with a Potent Growth-inhibitory Effect on Cancer Cells
Mol. Cancer Ther., August 1, 2002; 1(10): 811 - 819.
[Abstract] [Full Text] [PDF]


Home page
Molecular Cancer TherapeuticsHome page
Y. Imai, M. Nakane, K. Kage, S. Tsukahara, E. Ishikawa, T. Tsuruo, Y. Miki, and Y. Sugimoto
C421A Polymorphism in the Human Breast Cancer Resistance Protein Gene Is Associated with Low Expression of Q141K Protein and Low-Level Drug Resistance
Mol. Cancer Ther., June 1, 2002; 1(8): 611 - 616.
[Abstract] [Full Text] [PDF]


Home page
Molecular Cancer TherapeuticsHome page
D. DeFeo-Jones, S. F. Brady, D.-M. Feng, B. K. Wong, T. Bolyar, K. Haskell, D. M. Kiefer, K. Leander, E. McAvoy, P. Lumma, et al.
A Prostate-specific Antigen (PSA)-activated Vinblastine Prodrug Selectively Kills PSA-secreting Cells in Vivo
Mol. Cancer Ther., May 1, 2002; 1(7): 451 - 459.
[Abstract] [Full Text] [PDF]


Home page
JCOHome page
C. J. Allegra, A. L. Parr, L. E. Wold, M. R. Mahoney, D. J. Sargent, P. Johnston, P. Klein, K. Behan, M. J. O'Connell, R. Levitt, et al.
Investigation of the Prognostic and Predictive Value of Thymidylate Synthase, p53, and Ki-67 in Patients With Locally Advanced Colon Cancer
J. Clin. Oncol., April 1, 2002; 20(7): 1735 - 1743.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
Y. Zhou, F. G. Gwadry, W. C. Reinhold, L. D. Miller, L. H. Smith, U. Scherf, E. T. Liu, K. W. Kohn, Y. Pommier, and J. N. Weinstein
Transcriptional Regulation of Mitotic Genes by Camptothecin-induced DNA Damage: Microarray Analysis of Dose- and Time-dependent Effects
Cancer Res., March 1, 2002; 62(6): 1688 - 1695.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
P. B. Cassidy, P. J. Moos, R. C. Kelly, and F. A. Fitzpatrick
Cyclooxygenase-2 Induction by Paclitaxel, Docetaxel, and Taxane Analogues in Human Monocytes and Murine Macrophages: Structure-Activity Relationships and Their Implications
Clin. Cancer Res., March 1, 2002; 8(3): 846 - 855.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
K. Szepeshazi, A. V. Schally, G. Halmos, P. Armatis, F. Hebert, B. Sun, A. Feil, H. Kiaris, and A. Nagy
Targeted Cytotoxic Somatostatin Analogue AN-238 Inhibits Somatostatin Receptor-positive Experimental Colon Cancers Independently of Their p53 Status
Cancer Res., February 1, 2002; 62(3): 781 - 788.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
C. Huisman, C. G. Ferreira, L. E. Broker, J. A. Rodriguez, E. F. Smit, P. E. Postmus, F. A. E. Kruyt, and G. Giaccone
Paclitaxel Triggers Cell Death Primarily via Caspase-independent Routes in the Non-Small Cell Lung Cancer Cell Line NCI-H460
Clin. Cancer Res., February 1, 2002; 8(2): 596 - 606.
[Abstract] [Full Text] [PDF]


Home page
J. Pharmacol. Exp. Ther.Home page
P. Russo, C. Ottoboni, D. Malacarne, A. Crippa, J.-F. Riou, and P. M. O'Connor
Nonpeptidomimetic Farnesyltransferase Inhibitor RPR-115135 Increases Cytotoxicity of 5-Fluorouracil: Role of p53
J. Pharmacol. Exp. Ther., January 1, 2002; 300(1): 220 - 226.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
K. W. Crawford and W. D. Bowen
Sigma-2 Receptor Agonists Activate a Novel Apoptotic Pathway and Potentiate Antineoplastic Drugs in Breast Tumor Cell Lines
Cancer Res., January 1, 2002; 62(1): 313 - 322.
[Abstract] [Full Text] [PDF]


Home page
Molecular Cancer TherapeuticsHome page
K. B. Kim, R. Lotan, P. Yue, M. B. Sporn, N. Suh, G. W. Gribble, T. Honda, G. S. Wu, W. K. Hong, and S.-Y. Sun
Identification of a Novel Synthetic Triterpenoid, Methyl-2-cyano-3,12-dioxooleana-1,9-dien-28-oate, That Potently Induces Caspase-mediated Apoptosis in Human Lung Cancer Cells
Mol. Cancer Ther., January 1, 2002; 1(3): 177 - 184.
[Abstract] [Full Text] [PDF]


Home page
CarcinogenesisHome page
P. Karran
Mechanisms of tolerance to DNA damaging therapeutic drugs
Carcinogenesis, December 1, 2001; 22(12): 1931 - 1937.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
D. L. Kramer, B.-D. Chang, Y. Chen, P. Diegelman, K. Alm, A. R. Black, I. B. Roninson, and C. W. Porter
Polyamine Depletion in Human Melanoma Cells Leads to G1 Arrest Associated with Induction of p21WAF1/CIP1/SDI1, Changes in the Expression of p21-regulated Genes, and a Senescence-like Phenotype
Cancer Res., November 1, 2001; 61(21): 7754 - 7762.
[Abstract] [Full Text] [PDF]


Home page
Mol. Pharmacol.Home page
V. Smith, F. Raynaud, P. Workman, and L. R. Kelland
Characterization of a Human Colorectal Carcinoma Cell Line with Acquired Resistance to Flavopiridol
Mol. Pharmacol., November 1, 2001; 60(5): 885 - 893.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
H. Wang, L. Nan, D. Yu, S. Agrawal, and R. Zhang
Antisense Anti-MDM2 Oligonucleotides As a Novel Therapeutic Approach to Human Breast Cancer: In Vitro and in Vivo Activities and Mechanisms
Clin. Cancer Res., November 1, 2001; 7(11): 3613 - 3624.
[Abstract] [Full Text] [PDF]


Home page
CarcinogenesisHome page
R. D. Abeysinghe, B. T. Greene, R. Haynes, M. C. Willingham, J. Turner, R. P. Planalp, M.W. Brechbiel, F. M. Torti, and S. V. Torti
p53-independent apoptosis mediated by tachpyridine, an anti-cancer iron chelator
Carcinogenesis, October 1, 2001; 22(10): 1607 - 1614.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 1997 by the American Association for Cancer Research.