Cancer Research Audrey Hepburn Telomeres
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
[Cancer Research 57, 195-198, January 15, 1997]
© 1997 American Association for Cancer Research
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Shirai, T.
Right arrow Articles by Ito, N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Shirai, T.
Right arrow Articles by Ito, N.

The Prostate: A Target for Carcinogenicity of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) Derived from Cooked Foods1

Tomoyuki Shirai2, Masashi Sano, Seiko Tamano, Satoru Takahashi, Masao Hirose, Mitsuru Futakuchi, Ryohei Hasegawa, Katsumi Imaida, Ken-ichiro Matsumoto, Keiji Wakabayashi, Takashi Sugimura and Nobuyuki Ito

First Department of Pathology, Nagoya City University Medical School, 1-Kawasumi, Muzuho-cho, Mizuho-ku, Nagoya 467, Japan [T. Sh., M. S., M. F., S. Tak., M. H., R. H., K. I., N. I.]; Daiyu-kai Institute of Medical Science, Nishiazai, Ichinomiya, Aichi-Prefecture 491-01, Japan [S. Tam.]; and Biochemistry Division, National Cancer Center Research Institute, 5-I-1 Tsukiji, Tokyo 104, Japan [K. M., K. W., T. Su.]

Prostate tissues obtained from rats given a food-derived carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), at a dose of 400 ppm in the diet for 52 weeks were histopathologically evaluated and found to contain prostate carcinomas limited to the ventral lobe in 18 of 27 cases. Atypical hyperplasias were also detected in the ventral and anterior prostate as well as the seminal vesicles. 32P-Postlabeling analysis of DNA demonstrated that PhIP-DNA adducts are produced in all lobes of the prostate of rats receiving PhIP. The findings indicate that PhIP is carcinogenic to rat prostate in addition to the previously demonstrated targeting of the colon and mammary glands, providing evidence of a possible role of PhIP in human prostate carcinogenesis and highlighting the potential importance of PhIP for man.

1 Supported in part by grants-in-aid for cancer research from the Ministry of Education, Science, Sports and Culture and the Ministry of Health and Welfare of Japan, a grant-in-aid from the Ministry of Health and Welfare for the Second-Term Comprehensive 10-Year Strategy for Cancer Control, Japan, and a grant from the Society for Promotion of Toxicological Pathology of Nagoya, Japan.

2 To whom requests for reprints should be addressed.

Received 10/ 7/96. Accepted 12/ 3/96.




This article has been cited by other articles:


Home page
 Am J EpidemiolHome page
R. Sinha, Y. Park, B. I. Graubard, M. F. Leitzmann, A. Hollenbeck, A. Schatzkin, and A. J. Cross
Meat and Meat-related Compounds and Risk of Prostate Cancer in a Large Prospective Cohort Study in the United States
Am. J. Epidemiol., November 1, 2009; 170(9): 1165 - 1177.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. Koutros, S. I. Berndt, R. Sinha, X. Ma, N. Chatterjee, M. C.R. Alavanja, T. Zheng, W.-Y. Huang, R. B. Hayes, and A. J. Cross
Xenobiotic Metabolizing Gene Variants, Dietary Heterocyclic Amine Intake, and Risk of Prostate Cancer
Cancer Res., March 1, 2009; 69(5): 1877 - 1884.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
D. W. Rosenberg, C. Giardina, and T. Tanaka
Mouse models for the study of colon carcinogenesis
Carcinogenesis, February 1, 2009; 30(2): 183 - 196.
[Abstract] [Full Text] [PDF]

Home page
 Drug Metab. Dispos.Home page
J.-F. Han, X.-Y. He, J. S. Herrington, L. A. White, J.-F. Zhang, and J.-Y. Hong
Metabolism of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) by Human CYP1B1 Genetic Variants
Drug Metab. Dispos., April 1, 2008; 36(4): 745 - 752.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
R. Wang, W.M. Dashwood, C. V. Lohr, K. A. Fischer, C. B. Pereira, M. Louderback, H. Nakagama, G. S. Bailey, D. E. Williams, and R. H. Dashwood
Protective versus promotional effects of white tea and caffeine on PhIP-induced tumorigenesis and {beta}-catenin expression in the rat
Carcinogenesis, April 1, 2008; 29(4): 834 - 839.
[Abstract] [Full Text] [PDF]

Home page
 Appl. Environ. Microbiol.Home page
L. Vanhaecke, F. Vercruysse, N. Boon, W. Verstraete, I. Cleenwerck, M. De Wachter, P. De Vos, and T. van de Wiele
Isolation and Characterization of Human Intestinal Bacteria Capable of Transforming the Dietary Carcinogen 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine
Appl. Envir. Microbiol., March 1, 2008; 74(5): 1469 - 1477.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
S. Koutros, A. J. Cross, D. P. Sandler, J. A. Hoppin, X. Ma, T. Zheng, M. C.R. Alavanja, and R. Sinha
Meat and Meat Mutagens and Risk of Prostate Cancer in the Agricultural Health Study
Cancer Epidemiol. Biomarkers Prev., January 1, 2008; 17(1): 80 - 87.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. K. Creton, H. Zhu, and N. J. Gooderham
The Cooked Meat Carcinogen 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine Activates the Extracellular Signal Regulated Kinase Mitogen-Activated Protein Kinase Pathway
Cancer Res., December 1, 2007; 67(23): 11455 - 11462.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. N. Lauber and N. J. Gooderham
The Cooked Meat Derived Genotoxic Carcinogen 2-Amino-3-Methylimidazo[4,5-b]Pyridine Has Potent Hormone-Like Activity: Mechanistic Support for a Role in Breast Cancer
Cancer Res., October 1, 2007; 67(19): 9597 - 9602.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
D. Tang, J. J. Liu, A. Rundle, C. Neslund-Dudas, A. T. Savera, C. H. Bock, N. L. Nock, J. J. Yang, and B. A. Rybicki
Grilled Meat Consumption and PhIP-DNA Adducts in Prostate Carcinogenesis
Cancer Epidemiol. Biomarkers Prev., April 1, 2007; 16(4): 803 - 808.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
Y. Nakai, W. G. Nelson, and A. M. De Marzo
The Dietary Charred Meat Carcinogen 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine Acts as Both a Tumor Initiator and Promoter in the Rat Ventral Prostate
Cancer Res., February 1, 2007; 67(3): 1378 - 1384.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
N. J. Butcher, N. L. Tetlow, C. Cheung, G. M. Broadhurst, and R. F. Minchin
Induction of Human Arylamine N-Acetyltransferase Type I by Androgens in Human Prostate Cancer Cells
Cancer Res., January 1, 2007; 67(1): 85 - 92.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. A. Malfatti, K. H. Dingley, S. Nowell-Kadlubar, E. A. Ubick, N. Mulakken, D. Nelson, N. P. Lang, J. S. Felton, and K. W. Turteltaub
The Urinary Metabolite Profile of the Dietary Carcinogen 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine Is Predictive of Colon DNA Adducts after a Low-Dose Exposure in Humans
Cancer Res., November 1, 2006; 66(21): 10541 - 10547.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
C. Rodriguez, M. L. McCullough, A. M. Mondul, E. J. Jacobs, A. Chao, A. V. Patel, M. J. Thun, and E. E. Calle
Meat Consumption among Black and White Men and Risk of Prostate Cancer in the Cancer Prevention Study II Nutrition Cohort.
Cancer Epidemiol. Biomarkers Prev., February 1, 2006; 15(2): 211 - 216.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. J. Cross, U. Peters, V. A. Kirsh, G. L. Andriole, D. Reding, R. B. Hayes, and R. Sinha
A Prospective Study of Meat and Meat Mutagens and Prostate Cancer Risk
Cancer Res., December 15, 2005; 65(24): 11779 - 11784.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
M. A. Malfatti, E. A. Ubick, and J. S. Felton
The impact of glucuronidation on the bioactivation and DNA adduction of the cooked-food carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in vivo
Carcinogenesis, November 1, 2005; 26(11): 2019 - 2028.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
G. S. Palapattu, S. Sutcliffe, P. J. Bastian, E. A. Platz, A. M. De Marzo, W. B. Isaacs, and W. G. Nelson
Prostate carcinogenesis and inflammation: emerging insights
Carcinogenesis, July 1, 2005; 26(7): 1170 - 1181.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
K. E. Bachman, J. Sager, I. Cheong, M. Catto, A. Bardelli, B. H. Park, B. Vogelstein, A. Carotti, K. W. Kinzler, and C. Lengauer
Identification of compounds that inhibit growth of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine-resistant cancer cells
Mol. Cancer Ther., June 1, 2005; 4(6): 1026 - 1030.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
S. Creton, H. Zhu, and N. J. Gooderham
A Mechanistic Basis for the Role of Cycle Arrest in the Genetic Toxicology of the Dietary Carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)
Toxicol. Sci., April 1, 2005; 84(2): 335 - 343.
[Abstract] [Full Text] [PDF]

Home page
 MutagenesisHome page
Y. Mori, A. Koide, K. Tatematsu, S. Sugie, and H. Mori
Effects of {alpha}-naphthyl isothiocyanate and a heterocyclic amine, PhIP, on cytochrome P-450, mutagenic activation of various carcinogens and glucuronidation in rat liver
Mutagenesis, January 1, 2005; 20(1): 15 - 22.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
B. A. Rybicki, A. Rundle, A. T. Savera, S. S. Sankey, and D. Tang
Polycyclic Aromatic Hydrocarbon-DNA Adducts in Prostate Cancer
Cancer Res., December 15, 2004; 64(24): 8854 - 8859.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
W. G. Nelson
Prostate Cancer Prevention
J. Nutr., November 1, 2004; 134(11): 3211S - 3212S.
[Full Text] [PDF]

Home page
 CarcinogenesisHome page
D. G. Walters, P. J. Young, C. Agus, M. G. Knize, A. R. Boobis, N. J. Gooderham, and B. G. Lake
Cruciferous vegetable consumption alters the metabolism of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in humans
Carcinogenesis, September 1, 2004; 25(9): 1659 - 1669.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
A. R. Trzeciak, S. G. Nyaga, P. Jaruga, A. Lohani, M. Dizdaroglu, and M. K. Evans
Cellular repair of oxidatively induced DNA base lesions is defective in prostate cancer cell lines, PC-3 and DU-145
Carcinogenesis, August 1, 2004; 25(8): 1359 - 1370.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
S. Fukushima, H. Wanibuchi, K. Morimura, S. Iwai, D. Nakae, H. Kishida, H. Tsuda, N. Uehara, K. Imaida, T. Shirai, et al.
Existence of a Threshold for Induction of Aberrant Crypt Foci in the Rat Colon with Low Doses of 2-Amino-1-methyl-6-phenolimidazo[4,5-b]pyridine
Toxicol. Sci., July 1, 2004; 80(1): 109 - 114.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
A. Hikosaka, M. Asamoto, N. Hokaiwado, K. Kato, K. Kuzutani, K. Kohri, and T. Shirai
Inhibitory effects of soy isoflavones on rat prostate carcinogenesis induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)
Carcinogenesis, March 1, 2004; 25(3): 381 - 387.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
S. Nowell, D. L. Ratnasinghe, C. B. Ambrosone, S. Williams, T. Teague-Ross, L. Trimble, G. Runnels, A. Carrol, B. Green, A. Stone, et al.
Association of SULT1A1 Phenotype and Genotype with Prostate Cancer Risk in African-Americans and Caucasians
Cancer Epidemiol. Biomarkers Prev., February 1, 2004; 13(2): 270 - 276.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
K.-i. Masumura, Y. Totsuka, K. Wakabayashi, and T. Nohmi
Potent genotoxicity of aminophenylnorharman, formed from non-mutagenic norharman and aniline, in the liver of gpt delta transgenic mouse
Carcinogenesis, December 1, 2003; 24(12): 1985 - 1993.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
M. Nakayama, C. J. Bennett, J. L. Hicks, J. I. Epstein, E. A. Platz, W. G. Nelson, and A. M. De Marzo
Hypermethylation of the Human Glutathione S-Transferase-{pi} Gene (GSTP1) CpG Island Is Present in a Subset of Proliferative Inflammatory Atrophy Lesions but Not in Normal or Hyperplastic Epithelium of the Prostate: A Detailed Study Using Laser-Capture Microdissection
Am. J. Pathol., September 1, 2003; 163(3): 923 - 933.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
W. G. Nelson, A. M. De Marzo, and W. B. Isaacs
Prostate Cancer
N. Engl. J. Med., July 24, 2003; 349(4): 366 - 381.
[Full Text] [PDF]

Home page
 MutagenesisHome page
H. Yang, J. Holcroft, B. W. Glickman, and J. G. de Boer
Conjugated linoleic acid inhibits mutagenesis by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in the prostate of Big Blue(R) rats
Mutagenesis, March 1, 2003; 18(2): 195 - 200.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
P. L. Grover and F. L. Martin
The initiation of breast and prostate cancer
Carcinogenesis, July 1, 2002; 23(7): 1095 - 1102.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
M. Futakuchi, M. Hirose, K. Imaida, S. Takahashi, K. Ogawa, M. Asamoto, T. Miki, and T. Shirai
Chemoprevention of 2-amino-1-methyl-6-phenylimidazo- [4,5-b]pyridine-induced colon carcinogenesis by 1-O-hexyl-2,3,5-trimethylhydroquinone after initiation with 1,2-dimethylhydrazine in F344 rats
Carcinogenesis, February 1, 2002; 23(2): 283 - 287.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
S. Langouet, A. Paehler, D. H. Welti, N. Kerriguy, A. Guillouzo, and R. J. Turesky
Differential metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in rat and human hepatocytes
Carcinogenesis, January 1, 2002; 23(1): 115 - 122.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
I.-L. Steffensen, H. A. J. Schut, J. E. Paulsen, A. Andreassen, and J. Alexander
Intestinal Tumorigenesis in Multiple Intestinal Neoplasia Mice Induced by the Food Mutagen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine: Perinatal Susceptibility, Regional Variation, and Correlation with DNA Adducts
Cancer Res., December 1, 2001; 61(24): 8689 - 8696.
[Abstract] [Full Text] [PDF]

Home page
 MutagenesisHome page
G. R. Stuart, J. G. de Boer, R. Haesevoets, J. Holcroft, J. Kangas, K. Sojonky, E. Thorleifson, A. Thornton, D. F. Walsh, H. Yang, et al.
Mutations induced by 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP) in cecum and proximal and distal colon of lacI transgenic rats
Mutagenesis, September 1, 2001; 16(5): 431 - 437.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
K. Imaida, M. Sano, S. Tamano, M. Asamoto, K. Ogawa, M. Futakuchi, and T. Shirai
Organ dependent enhancement of rat 3,2'-dimethyl-4-aminobiphenyl (DMAB) carcinogenesis by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP): positive effects on the intestine but not the prostate
Carcinogenesis, August 1, 2001; 22(8): 1295 - 1299.
[Abstract] [Full Text] [PDF]

Home page
 MutagenesisHome page
A. Andreassen, R. Vikse, I.-L. Steffensen, J. E. Paulsen, and J. Alexander
Intestinal tumours induced by the food carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in multiple intestinal neoplasia mice have truncation mutations as well as loss of the wild-type Apc+ allele
Mutagenesis, July 1, 2001; 16(4): 309 - 315.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
K. Brown, E. A. Guenther, K. H. Dingley, M. Cosman, C. A. Harvey, S. J. Shields, and K. W. Turteltaub
Synthesis and spectroscopic characterization of site-specific 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine oligodeoxyribonucleotide adducts
Nucleic Acids Res., May 1, 2001; 29(9): 1951 - 1959.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. Bardelli, D. P. Cahill, G. Lederer, M. R. Speicher, K. W. Kinzler, B. Vogelstein, and C. Lengauer
Carcinogen-specific induction of genetic instability
PNAS, April 5, 2001; (2001) 81082898.
[Abstract] [Full Text]

Home page
 CarcinogenesisHome page
K. Imaida, S. Tamano, K. Kato, Y. Ikeda, M. Asamoto, S. Takahashi, Z. Nir, M. Murakoshi, H. Nishino, and T. Shirai
Lack of chemopreventive effects of lycopene and curcumin on experimental rat prostate carcinogenesis
Carcinogenesis, March 1, 2001; 22(3): 467 - 472.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
J.A. Williams
Single nucleotide polymorphisms, metabolic activation and environmental carcinogenesis: why molecular epidemiologists should think about enzyme expression
Carcinogenesis, February 1, 2001; 22(2): 209 - 214.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
A. J. Fretland, U. S. Devanaboyina, Y. Feng, M. A. Leff, G. H. Xiao, S. J. Webb, and D. W. Hein
Oral Administration of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) Yields PhIP-DNA Adducts but Not Tumors in Male Syrian Hamsters Congenic at the N-acetyltransferase 2 (NAT2) Locus
Toxicol. Sci., February 1, 2001; 59(2): 226 - 230.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
C. P. Nelson, L. C. R. Kidd, J. Sauvageot, W. B. Isaacs, A. M. De Marzo, J. D. Groopman, W. G. Nelson, and T. W. Kensler
Protection against 2-Hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine Cytotoxicity and DNA Adduct Formation in Human Prostate by Glutathione S-Transferase P1
Cancer Res., January 1, 2001; 61(1): 103 - 109.
[Abstract] [Full Text]

Home page
 JNCI J Natl Cancer InstHome page
C. P. Salmon, M. G. Knize, F. N. Panteleakos, R. W. Wu, D. O. Nelson, and J. S. Felton
Minimization of Heterocyclic Amines and Thermal Inactivation of Escherichia coli in Fried Ground Beef
J Natl Cancer Inst, November 1, 2000; 92(21): 1773 - 1778.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
K.-i. Masumura, K. Matsui, M. Yamada, M. Horiguchi, K. Ishida, M. Watanabe, K. Wakabayashi, and T. Nohmi
Characterization of mutations induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in the colon of gpt delta transgenic mouse: novel G:C deletions beside runs of identical bases
Carcinogenesis, November 1, 2000; 21(11): 2049 - 2056.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
K. S. Kulp, M. G. Knize, M. A. Malfatti, C. P. Salmon, and J. S. Felton
Identification of urine metabolites of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine following consumption of a single cooked chicken meal in humans
Carcinogenesis, November 1, 2000; 21(11): 2065 - 2072.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
J.A. Williams, F.L. Martin, G.H. Muir, A. Hewer, P.L. Grover, and D.H. Phillips
Metabolic activation of carcinogens and expression of various cytochromes P450 in human prostate tissue
Carcinogenesis, September 1, 2000; 21(9): 1683 - 1689.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
M. Wyss and R. Kaddurah-Daouk
Creatine and Creatinine Metabolism
Physiol Rev, July 1, 2000; 80(3): 1107 - 1213.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
G. R. Stuart, J. Holcroft, J. G. de Boer, and B. W. Glickman
Prostate Mutations in Rats Induced by the Suspected Human Carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
Cancer Res., January 1, 2000; 60(2): 266 - 268.
[Abstract] [Full Text]

Home page
 JNCI J Natl Cancer InstHome page
A. E. Norrish, L. R. Ferguson, M. G. Knize, J. S. Felton, S. J. Sharpe, and R. T. Jackson
Heterocyclic Amine Content of Cooked Meat and Risk of Prostate Cancer
J Natl Cancer Inst, December 1, 1999; 91(23): 2038 - 2044.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol PatholHome page
Y. Ikeda, S. Takahashi, J. Kimura, Y.-M. Cho, K. Imaida, S. Shirai, and T. Shirai
Anophthalmia in Litters of Female Rats Treated with the Food-Derived Carcinogen, 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine
Toxicol Pathol, November 1, 1999; 27(6): 628 - 631.
[Abstract] [PDF]

Home page
 CarcinogenesisHome page
U.K. Walle and T. Walle
Transport of the cooked-food mutagen 2-amino-1-methyl-6-phenylimidazo-[4,5-b]pyridine (PhIP) across the human intestinal Caco-2 cell monolayer: role of efflux pumps
Carcinogenesis, November 1, 1999; 20(11): 2153 - 2157.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
E. Okochi, N. Watanabe, Y. Shimada, S. Takahashi, K. Wakazono, T. Shirai, T. Sugimura, M. Nagao, and T. Ushijima
Preferential induction of guanine deletion at 5'-GGGA-3' in rat mammary glands by 2-amino- 1-methyl-6-phenylimidazo[4,5-b]pyridine
Carcinogenesis, October 1, 1999; 20(10): 1933 - 1938.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Shibutani, A. Fernandes, N. Suzuki, L. Zhou, F. Johnson, and A. P. Grollman
Mutagenesis of the N-(Deoxyguanosin-8-yl)-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine DNA Adduct in Mammalian Cells. SEQUENCE CONTEXT EFFECTS
J. Biol. Chem., September 24, 1999; 274(39): 27433 - 27438.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
C. Y. Wang, M. Debiec-Rychter, H. A.J. Schut, P. Morse, R. F. Jones, C. Archer, C. M. King, and G. P. Haas
N-Acetyltransferase expression and DNA binding of N-hydroxyheterocyclic amines in human prostate epithelium
Carcinogenesis, August 1, 1999; 20(8): 1591 - 1596.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
M. A. Leff, P. N. Epstein, M. A. Doll, A. J. Fretland, U.-S. Devanaboyina, T. D. Rustan, and D. W. Hein
Prostate-Specific Human N-Acetyltransferase 2 (NAT2) Expression in the Mouse
J. Pharmacol. Exp. Ther., July 1, 1999; 290(1): 182 - 187.
[Abstract] [Full Text]

Home page
 CarcinogenesisHome page
Y. Ishiguro, M. Ochiai, T. Sugimura, M. Nagao, and H. Nakagama
Strain differences of rats in the susceptibility to aberrant crypt foci formation by 2-amino-1-methyl-6-phenylimidazo- [4,5-b]pyridine: no implication of Apc and Pla2g2a genetic polymorphisms in differential susceptibility
Carcinogenesis, June 1, 1999; 20(6): 1063 - 1068.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
L. C. R. Kidd, W. G. Stillwell, M. C. Yu, J. S. Wishnok, P. L. Skipper, R. K. Ross, B. E. Henderson, and S. R. Tannenbaum
Urinary Excretion of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in White, African-American, and Asian-American Men in Los Angeles County
Cancer Epidemiol. Biomarkers Prev., May 1, 1999; 8(5): 439 - 445.
[Abstract] [Full Text]

Home page
 CarcinogenesisHome page
W. Pfau, F. L. Martin, K. J. Cole, S. Venitt, D. H. Phillips, P. L. Grover, and H. Marquardt
Heterocyclic aromatic amines induce DNA strand breaks and cell transformation
Carcinogenesis, April 1, 1999; 20(4): 545 - 551.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
M. A. Malfatti, K. S. Kulp, M. G. Knize, C. Davis, J. P. Massengill, S. Williams, S. Nowell, S. MacLeod, K. H. Dingley, K. W. Turteltaub, et al.
The identification of [2-14C]2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine metabolites in humans
Carcinogenesis, April 1, 1999; 20(4): 705 - 713.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
L. N. Kolonel, A. M. Y. Nomura, and R. V. Cooney
Dietary Fat and Prostate Cancer: Current Status
J Natl Cancer Inst, March 3, 1999; 91(5): 414 - 428.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
H. A.J. Schut and E. G. Snyderwine
DNA adducts of heterocyclic amine food mutagens: implications for mutagenesis and carcinogenesis
Carcinogenesis, March 1, 1999; 20(3): 353 - 368.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. Bardelli, D. P. Cahill, G. Lederer, M. R. Speicher, K. W. Kinzler, B. Vogelstein, and C. Lengauer
From the Cover: Carcinogen-specific induction of genetic instability
PNAS, May 8, 2001; 98(10): 5770 - 5775.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 1997 by the American Association for Cancer Research.