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Short-Chain Fructo-oligosaccharides Reduce the Occurrence of Colon Tumors and Develop Gut-associated Lymphoid Tissue in Min Mice¹

Institut National de la Santé et de la Recherche Médicale U 419, Human Nutrition Research Center of Nantes, Institute de Biologie, 9 quai Moncousu, F-44035 Nantes [F. P., P. P., K. M., J. M.], and Laboratoire de Technologie Appliquée à la Nutrition, Institut National de la Recherche Agronomique, Human Nutrition Research Center of Nantes, rue de la Géraudière, F-44316 Nantes [M. C.], France; and Eridania Beghin-Say, Vilvoorde Research and Development Centre, Nutrition and Health Service, Havenstraat 84, B-1800 Vilvoorde, Belgium [F. B.]

C57BL/6J-Min/+ mice, which are heterozygous for a non-sense mutation in the Apc gene, provide a model for both familial adenomatous polyposis and sporadic colon cancers. In our study, gut tumors and small intestine lymphoid nodules were counted in Min mice fed fiber-enriched diets for 6 weeks. Neither starch-free wheat bran nor resistant starch modified the number of tumors. However, short-chain fructo-oligosaccharides dramatically reduced the incidence of colon tumors and concomitantly developed gut-associated lymphoid tissue. Our experiment shows that short-chain fructo-oligosaccharides counteract advanced stages of colon carcinogenesis, possibly via stimulation of antitumoral immunity by modulation of the colonic ecosystem.

¹ This work was supported by Eridania Béghin-Say (Nutrition and Health Service, Vilvoorde, Belgium) and by the Conseil Général de Loire-Atlantique, Nantes, France.

² To whom requests for reprints should be addressed.

Received 10/ 9/96. Accepted 12/ 3/96.

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