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[Cancer Research 57, 300-303, January 15, 1997]
© 1997 American Association for Cancer Research

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BAT-26, an Indicator of the Replication Error Phenotype in Colorectal Cancers and Cell Lines1

Jean-Marc Hoang, Paul H. Cottu, Benedicte Thuille, Rémi J. Salmon, Gilles Thomas and Richard Hamelin2

Inserm U 434, Génétique des Tumeurs, Institut Curie, 26 rue d'Ulm, 75005 Paris, France

Instability of microsatellites is a hallmark of the DNA replication error phenotype (RER+) due to the inactivation of mismatch repair genes. In humans, microsatellite instability has first been described in colorectal tumors developing in either hereditary nonpolyposis colorectal cancer or sporadic patients. Colorectal tumorigenesis in RER+ and RER- tumors is probably due to distinct mechanisms, and RER+ tumors have a better prognosis than RER- tumors. The study of the RER status of a tumor may thus be important in the future to determine biological prognosis factors and investigate therapeutical strategies. The RER status of 134 primary tumors and 26 cell lines derived from colorectal cancers was established by PCR amplification and analysis of a minimum of 32 microsatellite loci. This characterization allowed us to unambiguously classify 35 primary tumors and 7 cell lines as RER+. Typing of a single poly(A) tract, BAT-26, was sufficient to confirm the RER status of 159 of these 160 tumors and cell lines. Moreover, in DNA from unaffected individuals, normal tissues of a subset of the RER+ patients, and all RER- tumors or cell lines, BAT-26 was quasi-monomorphic, showing only minor size variations. BAT-26 alleles showing shortening from 4 to 15 bp were observed in all but 1 of the RER+ tumors and cell lines. The size difference between the range of normal large alleles and unstable small alleles was sufficient to be detected by electrophoresis on conventional polyacrylamide gels stained with ethidium bromide. We thus propose a simple, low-cost, and rapid method to screen for the RER status of colorectal cancer primary tumors and cell lines, even in the absence of matching normal DNA and, in most cases, without the need for radioactivity. This method could easily be set up in routine laboratories.

1 This work was supported by grants from the Association pour la Recherche contre le Cancer and the Association Française contre les Myopathies. J-M. Hoang was supported by a grant from the Ligue Nationale contre le Cancer.

2 To whom requests for reprints should be addressed. Phone: 33-1-42-34-66-83; Fax: 33-1-42-34-66-30; E-mail: rhamelin@curie.fr.

Received 7/16/96. Accepted 11/14/96.




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Home page
J. Med. Genet.Home page
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J. Med. Genet., January 1, 2004; 41(1): e3 - 3.
[Full Text] [PDF]


Home page
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[Abstract] [Full Text] [PDF]


Home page
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[Abstract] [Full Text] [PDF]


Home page
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[Abstract] [Full Text] [PDF]


Home page
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[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
A. Hartmann, L. Zanardo, T. Bocker-Edmonston, H. Blaszyk, W. Dietmaier, R. Stoehr, J. C. Cheville, K. Junker, W. Wieland, R. Knuechel, et al.
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Cancer Res., December 1, 2002; 62(23): 6796 - 6802.
[Abstract] [Full Text] [PDF]


Home page
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I. Gonzalez-Garcia, R. V. Sole, and J. Costa
Metapopulation dynamics and spatial heterogeneity in cancer
PNAS, October 1, 2002; 99(20): 13085 - 13089.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
S. S. Wahlberg, J. Schmeits, G. Thomas, M. Loda, J. Garber, S. Syngal, R. D. Kolodner, and E. Fox
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Cancer Res., June 1, 2002; 62(12): 3485 - 3492.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Pathol.Home page
S. A. Kuismanen, A.-L. Moisio, P. Schweizer, K. Truninger, R. Salovaara, J. Arola, R. Butzow, J. Jiricny, M. Nystrom-Lahti, and P. Peltomaki
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Am. J. Pathol., June 1, 2002; 160(6): 1953 - 1958.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
J. Park, D. Betel, R. Gryfe, K. Michalickova, N. Di Nicola, S. Gallinger, C. W. V. Hogue, and M. Redston
Mutation Profiling of Mismatch Repair-deficient Colorectal Cancers Using an in Silico Genome Scan to Identify Coding Microsatellites
Cancer Res., March 1, 2002; 62(5): 1284 - 1288.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
A. Duval, M. Reperant, A. Compoint, R. Seruca, G. N. Ranzani, B. Iacopetta, and R. Hamelin
Target Gene Mutation Profile Differs between Gastrointestinal and Endometrial Tumors with Mismatch Repair Deficiency
Cancer Res., March 1, 2002; 62(6): 1609 - 1612.
[Abstract] [Full Text] [PDF]


Home page
JCOHome page
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J. Clin. Oncol., February 1, 2002; 20(3): 811 - 816.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
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Cancer Res., January 1, 2002; 62(1): 38 - 42.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
T. Liu, H. Yan, S. Kuismanen, A. Percesepe, M.-L. Bisgaard, M. Pedroni, P. Benatti, K. W. Kinzler, B. Vogelstein, M. Ponz de Leon, et al.
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Cancer Res., November 1, 2001; 61(21): 7798 - 7802.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
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Microsatellite Instability in Thyroid Cancer: Hot Spots, Clinicopathological Implications, and Prognostic Significance
Clin. Cancer Res., November 1, 2001; 7(11): 3444 - 3449.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
D. Karan, B. M. Schmied, B. J. Dave, U. A. Wittel, M.-F. Lin, and S. K. Batra
Decreased Androgen-responsive Growth of Human Prostate Cancer Is Associated with Increased Genetic Alterations
Clin. Cancer Res., November 1, 2001; 7(11): 3472 - 3480.
[Abstract] [Full Text] [PDF]


Home page
JCOHome page
A. Percesepe, F. Borghi, M. Menigatti, L. Losi, M. Foroni, C. Di Gregorio, G. Rossi, M. Pedroni, E. Sala, F. Vaccina, et al.
Molecular Screening for Hereditary Nonpolyposis Colorectal Cancer: A Prospective, Population-Based Study
J. Clin. Oncol., October 1, 2001; 19(19): 3944 - 3950.
[Abstract] [Full Text]


Home page
Mol. Pathol.Home page
L A Clarke, C S Rebelo, J Goncalves, M G Boavida, and P Jordan
PCR amplification introduces errors into mononucleotide and dinucleotide repeat sequences
Mol. Pathol., October 1, 2001; 54(5): 351 - 353.
[Abstract] [Full Text] [PDF]


Home page
Cancer Epidemiol. Biomarkers Prev.Home page
W. S. Samowitz, K. Curtin, K.-N. Ma, D. Schaffer, L. W. Coleman, M. Leppert, and M. L. Slattery
Microsatellite Instability in Sporadic Colon Cancer Is Associated with an Improved Prognosis at the Population Level
Cancer Epidemiol. Biomarkers Prev., September 1, 2001; 10(9): 917 - 923.
[Abstract] [Full Text] [PDF]


Home page
J. Med. Genet.Home page
T. Liu, J. Chen, S. Salahshor, S. Kuismanen, E. Holmberg, H. Gronberg, P. Peltomaki, and A. Lindblom
Screening families with endometrial and colorectal cancers for germline mutations
J. Med. Genet., September 1, 2001; 38(9): e29 - 29.
[Full Text] [PDF]


Home page
J. Clin. Pathol.Home page
T Ishitsuka, H Kashiwagi, and F Konishi
Microsatellite instability in inflamed and neoplastic epithelium in ulcerative colitis
J. Clin. Pathol., July 1, 2001; 54(7): 526 - 532.
[Abstract] [Full Text] [PDF]


Home page
JNCI J Natl Cancer InstHome page
W. Atkin and J. P. Martin
Stool DNA-Based Colorectal Cancer Detection: Finding the Needle in the Haystack
J Natl Cancer Inst, June 6, 2001; 93(11): 798 - 799.
[Full Text] [PDF]


Home page
Cancer Res.Home page
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Application of the National Cancer Institute International Criteria for Determination of Microsatellite Instability in Ovarian Cancer
Cancer Res., June 1, 2001; 61(11): 4371 - 4374.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
A. Loukola, K. Eklin, P. Laiho, R. Salovaara, P. Kristo, H. Jarvinen, J.-P. Mecklin, V. Launonen, and L. A. Aaltonen
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Cancer Res., June 1, 2001; 61(11): 4545 - 4549.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
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Cancer Res., May 1, 2001; 61(9): 3801 - 3805.
[Abstract] [Full Text]


Home page
Am. J. Pathol.Home page
W. S. Samowitz, J. A. Holden, K. Curtin, S. L. Edwards, A. R. Walker, H. A. Lin, M. A. Robertson, M. F. Nichols, K. M. Gruenthal, B. J. Lynch, et al.
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[Abstract] [Full Text] [PDF]


Home page
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Hum. Mol. Genet., March 1, 2001; 10(5): 513 - 518.
[Abstract] [Full Text] [PDF]


Home page
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Gut, March 1, 2001; 48(3): 367 - 371.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
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Cancer Res., March 1, 2001; 61(5): 2124 - 2128.
[Abstract] [Full Text]


Home page
Cancer Res.Home page
J. Huang, S. A. Kuismanen, T. Liu, R. B. Chadwick, C. K. Johnson, M. W. Stevens, S. K. Richards, J. E. Meek, X. Gao, F. A. Wright, et al.
MSH6 and MSH3 Are Rarely Involved in Genetic Predisposition to Nonpolypotic Colon Cancer
Cancer Res., February 1, 2001; 61(4): 1619 - 1623.
[Abstract] [Full Text]


Home page
Am. J. Pathol.Home page
J. Alexander, T. Watanabe, T.-T. Wu, A. Rashid, S. Li, and S. R. Hamilton
Histopathological Identification of Colon Cancer with Microsatellite Instability
Am. J. Pathol., February 1, 2001; 158(2): 527 - 535.
[Abstract] [Full Text] [PDF]


Home page
JNCI J Natl Cancer InstHome page
M. L. Slattery, K. Curtin, K. Anderson, K.-N. Ma, L. Ballard, S. Edwards, D. Schaffer, J. Potter, M. Leppert, and W. S. Samowitz
Associations Between Cigarette Smoking, Lifestyle Factors, and Microsatellite Instability in Colon Tumors
J Natl Cancer Inst, November 15, 2000; 92(22): 1831 - 1836.
[Abstract] [Full Text] [PDF]


Home page
J. Clin. Pathol.Home page
K Shitoh, F Konishi, M Miyaki, T Iijima, T Furukawa, T Tsukamoto, and H Nagai
Pathogenesis of non-familial colorectal carcinomas with high microsatellite instability
J. Clin. Pathol., November 1, 2000; 53(11): 841 - 845.
[Abstract] [Full Text] [PDF]


Home page
J. Med. Genet.Home page
C. VAURS-BARRIÈRE, F. PENAULT-LLORCA, V. LAPLACE-MARIEZE, N. PRESNEAU, C. M MAUGARD, M. FICHE, A. HARDOUIN, and Y.-J. BIGNON
Low frequency of microsatellite instability in BRCA1 mutated breast tumours
J. Med. Genet., October 1, 2000; 37(10): 32e - 32.
[Full Text]


Home page
GutHome page
J M D WHEELER, W F BODMER, and N J M. MORTENSEN
DNA mismatch repair genes and colorectal cancer
Gut, July 1, 2000; 47(1): 148 - 153.
[Full Text] [PDF]


Home page
Cancer Res.Home page
A. Duval, S. Rolland, E. Tubacher, H. Bui, G. Thomas, and R. Hamelin
The Human T-Cell Transcription Factor-4 Gene: Structure, Extensive Characterization of Alternative Splicings, and Mutational Analysis in Colorectal Cancer Cell Lines
Cancer Res., July 1, 2000; 60(14): 3872 - 3879.
[Abstract] [Full Text]


Home page
J. Med. Genet.Home page
M. RAVNIK-GLAVAC, U. POTOCNIK, and D. GLAVAC
Incidence of germline hMLH1 and hMSH2 mutations (HNPCC patients) among newly diagnosed colorectal cancers in a Slovenian population
J. Med. Genet., July 1, 2000; 37(7): 533 - 536.
[Full Text]


Home page
JCOHome page
R. Salovaara, A. Loukola, P. Kristo, H. Kaariainen, H. Ahtola, M. Eskelinen, N. Harkonen, R. Julkunen, E. Kangas, S. Ojala, et al.
Population-Based Molecular Detection of Hereditary Nonpolyposis Colorectal Cancer
J. Clin. Oncol., June 11, 2000; 18(11): 2193 - 2200.
[Abstract] [Full Text] [PDF]


Home page
Cancer Epidemiol. Biomarkers Prev.Home page
A. Chao, F. Gilliland, C. Willman, N. Joste, I-M. Chen, N. Stone, J. Ruschulte, D. Viswanatha, P. Duncan, R. Ming, et al.
Patient and Tumor Characteristics of Colon Cancers with Microsatellite Instability: A Population-based Study
Cancer Epidemiol. Biomarkers Prev., June 1, 2000; 9(6): 539 - 544.
[Abstract] [Full Text]


Home page
GutHome page
K Yamashita, Y Arimura, S Kurokawa, F Itoh, T Endo, K Hirata, A Imamura, M Kondo, T Sato, and K Imai
Microsatellite instability in patients with multiple primary cancers of the gastrointestinal tract
Gut, June 1, 2000; 46(6): 790 - 794.
[Abstract] [Full Text] [PDF]


Home page
JNCI J Natl Cancer InstHome page
I. Gonzalez-Garcia, V. Moreno, M. Navarro, J. Marti-Rague, E. Marcuello, C. Benasco, O. Campos, G. Capella, and M. A. Peinado
Standardized Approach for Microsatellite Instability Detection in Colorectal Carcinomas
J Natl Cancer Inst, April 5, 2000; 92(7): 544 - 549.
[Abstract] [Full Text] [PDF]


Home page
Hum Mol GenetHome page
R. Sturzeneker, R. A.U. Bevilacqua, L. A. Haddad, A. J.G. Simpson, and S. D.J. Pena
Microsatellite instability in tumors as a model to study the process of microsatellite mutations
Hum. Mol. Genet., February 12, 2000; 9(3): 347 - 352.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Pathol.Home page
W. K. Leung, J. J. Kim, J. G. Kim, D. Y. Graham, and A. R. Sepulveda
Microsatellite Instability in Gastric Intestinal Metaplasia in Patients with and without Gastric Cancer
Am. J. Pathol., February 1, 2000; 156(2): 537 - 543.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Pathol.Home page
M. Esteller, L. Catasus, X. Matias-Guiu, G. L. Mutter, J. Prat, S. B. Baylin, and J. G. Herman
hMLH1 Promoter Hypermethylation Is an Early Event in Human Endometrial Tumorigenesis
Am. J. Pathol., November 1, 1999; 155(5): 1767 - 1772.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
S. A. Kuismanen, M. T. Holmberg, R. Salovaara, P. Schweizer, L. A. Aaltonen, A. de la Chapelle, M. Nystrom-Lahti, and P. Peltomaki
Epigenetic phenotypes distinguish microsatellite-stable and -unstable colorectal cancers
PNAS, October 26, 1999; 96(22): 12661 - 12666.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
A. Duval, J. Gayet, X.-P. Zhou, B. Iacopetta, G. Thomas, and R. Hamelin
Frequent Frameshift Mutations of the TCF-4 Gene in Colorectal Cancers with Microsatellite Instability
Cancer Res., September 1, 1999; 59(17): 4213 - 4215.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Pathol.Home page
R. Pyatt, R. B. Chadwick, C. K. Johnson, C. Adebamowo, A. de la Chapelle, and T. W. Prior
Polymorphic Variation at the BAT-25 and BAT-26 Loci in Individuals of African Origin : Implications for Microsatellite Instability Testing
Am. J. Pathol., August 1, 1999; 155(2): 349 - 353.
[Abstract] [Full Text] [PDF]


Home page
GutHome page
I M FRAYLING
Microsatellite instability
Gut, July 1, 1999; 45(1): 1 - 4.
[Full Text] [PDF]


Home page
GutHome page
C Lamberti, R Kruse, C Ruelfs, R Caspari, Y Wang, M Jungck, M Mathiak, H R H Malayeri, W Friedl, T Sauerbruch, et al.
Microsatellite instability---a useful diagnostic tool to select patients at high risk for hereditary non-polyposis colorectal cancer: a study in different groups of patients with colorectal cancer
Gut, June 1, 1999; 44(6): 839 - 843.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
S. Schwartz Jr., H. Yamamoto, M. Navarro, M. Maestro, J. Reventos, and M. Perucho
Frameshift Mutations at Mononucleotide Repeats in caspase-5 and Other Target Genes in Endometrial and Gastrointestinal Cancer of the Microsatellite Mutator Phenotype
Cancer Res., June 1, 1999; 59(12): 2995 - 3002.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Pathol.Home page
W. S. Samowitz, M. L. Slattery, J. D. Potter, and M. F. Leppert
BAT-26 and BAT-40 Instability in Colorectal Adenomas and Carcinomas and Germline Polymorphisms
Am. J. Pathol., June 1, 1999; 154(6): 1637 - 1641.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
G. Deng, A. Chen, J. Hong, H. S. Chae, and Y. S. Kim
Methylation of CpG in a Small Region of the hMLH1 Promoter Invariably Correlates with the Absence of Gene Expression
Cancer Res., May 1, 1999; 59(9): 2029 - 2023.
[Abstract] [Full Text] [PDF]


Home page
CarcinogenesisHome page
K. Gotoh, Y. Yatabe, T. Sugiura, K. Takagi, M. Ogawa, T. Takahashi, and T. Mitsudomi
Frameshift mutations in TGFßRII, IGFIIR, BAX, hMSH3 and hMSH6 are absent in lung cancers
Carcinogenesis, March 1, 1999; 20(3): 499 - 502.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
M. Perucho, C. R. Boland, S. N. Thibodeau, S. R. Hamilton, D. Sidransky, J. R. Eshleman, R. W. Burt, S. J. Meltzer, M. A. Rodriguez-Bigas, R. Fodde, et al.
Correspondence re: C. R. Boland et al. A National Cancer Institute Workshop on Microsatellite Instability for Cancer Detection and Familial Predisposition: Development of International Criteria for the Determination of Microsatellite Instability in Colorectal Cancer. Cancer Res., 58: 5248-5257, 1998
Cancer Res., January 1, 1999; 59(1): 249 - 256.
[Full Text] [PDF]


Home page
Am. J. Pathol.Home page
T. Fujiwara, J. M. Stolker, T. Watanabe, A. Rashid, P. Longo, J. R. Eshleman, S. Booker, H. T. Lynch, J. R. Jass, J. S. Green, et al.
Accumulated Clonal Genetic Alterations in Familial and Sporadic Colorectal Carcinomas with Widespread Instability in Microsatellite Sequences
Am. J. Pathol., October 1, 1998; 153(4): 1063 - 1078.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Pathol.Home page
C. Oliveira, R. Seruca, M. Seixas, and M. Sobrinho-Simoes
The Clinicopathological Features of Gastric Carcinomas with Microsatellite Instability May Be Mediated by Mutations of Different ""Target Genes"" : A Study of the TGFß RII, IGFII R, and BAX Genes
Am. J. Pathol., October 1, 1998; 153(4): 1211 - 1219.
[Abstract] [Full Text] [PDF]


Home page
NEJMHome page
L. A. Aaltonen, R. Salovaara, P. Kristo, F. Canzian, A. Hemminki, P. Peltomaki, R. B. Chadwick, H. Kaariainen, M. Eskelinen, H. Jarvinen, et al.
Incidence of Hereditary Nonpolyposis Colorectal Cancer and the Feasibility of Molecular Screening for the Disease
N. Engl. J. Med., May 21, 1998; 338(21): 1481 - 1487.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
S. Olschwang, R. Hamelin, P. Laurent-Puig, B. Thuille, Y. De Rycke, Y.-J. Li, F. Muzeau, J. Girodet, R.-J. Salmon, and G. Thomas
Alternative genetic pathways in colorectal carcinogenesis
PNAS, October 28, 1997; 94(22): 12122 - 12127.
[Abstract] [Full Text] [PDF]




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