Cancer Research Meeting Calendar Genetics and Biology of Brain Cancer
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
[Cancer Research 57, 4992-4996, November 15, 1997]
© 1997 American Association for Cancer Research
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Xu, X.-C.
Right arrow Articles by Lotan, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Xu, X.-C.
Right arrow Articles by Lotan, R.

Progressive Decrease in Nuclear Retinoic Acid Receptor ß Messenger RNA Level during Breast Carcinogenesis1

Xiao-Chun Xu, Nour Sneige, Xiaoming Liu, Raju Nandagiri, J. Jack Lee, Farzana Lukmanji, Gabriel Hortobagyi, Scott M. Lippman, Kapil Dhingra2 and Reuben Lotan3

Departments of Clinical Cancer Frevention [X-C. X., X. L., S. M. L.], tumor Biology [R. L.], Pathology [N. S., R. N.], Biomathematics [J. J. L.], Epidemiology [F. L.], and Breast Medical Oncology [G. H., K. D.], The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030

Some of the nuclear retinoic acid receptors (RARs) {alpha}, ß, and {gamma} and retinoid X receptors (RXRs) {alpha}, ß, and {gamma} are thought to mediate the effects of retinoids on cell growth, differentiation, and apoptosis and thereby prevent breast carcinogenesis. We analyzed the expression of mRNAs for the three RARs and RXR-{alpha} in histological sections of specimens from 70 breast cancer patients, which included adjacent normal tissue, ductal carcinoma in situ, and invasive cancer, using in situ hybridization. RARs {alpha}, ß, and {gamma} and RXR-{alpha} were expressed in 98.1, 98.0, 93.0, and 100% of the adjacent normal tissues. Significant decreases in the number of cases expressing RAR-ß were observed among ductal carcinoma in situ (83.1%) and invasive carcinomas (51.6%), especially among the poorly differentiated cases (77.4 and 35.7%, respectively). No relationship was found between the expression of estrogen receptor and RAR-ß. These results implicate decreases in RAR-ß expression in breast cancer development and suggest that they are independent of estrogen receptor status.

1 Supported in part by grants from the Nelly Connally Breast Cancer Research Fund (to R. L.) and CN-45006-32 from the National Cancer Institute (to K. D.).

2 Present address: Department of Medical Cancer Research, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285.

3 To whom requests for reprints should be addressed, at the Department of Tumor Biology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Box 236 Houston, TX 77030. Phone: (713) 792-7480; Fax: (713) 794-0209.

Received 9/ 3/97. Accepted 10/ 2/97.




This article has been cited by other articles:


Home page
 Cancer Res.Home page
H. Chen, H. Zhang, J. Lee, X. Liang, X. Wu, T. Zhu, P.-k. Lo, X. Zhang, and S. Sukumar
HOXA5 Acts Directly Downstream of Retinoic Acid Receptor {beta} and Contributes to Retinoic Acid Induced Apoptosis and Growth Inhibition
Cancer Res., September 1, 2007; 67(17): 8007 - 8013.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. Huang, Z. D. Liang, T.-T. Wu, A. Hoque, H. Chen, Y. Jiang, H. Zhang, and X.-c. Xu
Tumor-Suppressive Effect of Retinoid Receptor-Induced Gene-1 (RRIG1) in Esophageal Cancer
Cancer Res., February 15, 2007; 67(4): 1589 - 1593.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
P. Germain, P. Chambon, G. Eichele, R. M. Evans, M. A. Lazar, M. Leid, A. R. De Lera, R. Lotan, D. J. Mangelsdorf, and H. Gronemeyer
International Union of Pharmacology. LX. Retinoic Acid Receptors
Pharmacol. Rev., December 1, 2006; 58(4): 712 - 725.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
B. Lefebvre, C. Brand, S. Flajollet, and P. Lefebvre
Down-Regulation of the Tumor Suppressor Gene Retinoic Acid Receptor {beta}2 through the Phosphoinositide 3-Kinase/Akt Signaling Pathway
Mol. Endocrinol., September 1, 2006; 20(9): 2109 - 2121.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
C. M. Banwell, D. P. MacCartney, M. Guy, A. E. Miles, M. R. Uskokovic, J. Mansi, P. M. Stewart, L. P. O'Neill, B. M. Turner, K. W. Colston, et al.
Altered nuclear receptor corepressor expression attenuates vitamin d receptor signaling in breast cancer cells.
Clin. Cancer Res., April 1, 2006; 12(7): 2004 - 2013.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
R. Elisei, A. Vivaldi, L. Agate, R. Ciampi, E. Molinaro, P. Piampiani, C. Romei, P. Faviana, F. Basolo, P. Miccoli, et al.
All-Trans-Retinoic Acid Treatment Inhibits the Growth of Retinoic Acid Receptor {beta} Messenger Ribonucleic Acid Expressing Thyroid Cancer Cell Lines but Does Not Reinduce the Expression of Thyroid-Specific Genes
J. Clin. Endocrinol. Metab., April 1, 2005; 90(4): 2403 - 2411.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
N. P. Mongan and L. J. Gudas
Valproic acid, in combination with all-trans retinoic acid and 5-aza-2'-deoxycytidine, restores expression of silenced RAR{beta}2 in breast cancer cells
Mol. Cancer Ther., March 1, 2005; 4(3): 477 - 486.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
E. F. Farias, D. E. Ong, N. B. Ghyselinck, S. Nakajo, Y. S. Kuppumbatti, and R. Mira y Lopez
Cellular Retinol-Binding Protein I, a Regulator of Breast Epithelial Retinoic Acid Receptor Activity, Cell Differentiation, and Tumorigenicity
J Natl Cancer Inst, January 5, 2005; 97(1): 21 - 29.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Takano, S. Adachi, M. Okuno, Y. Muto, T. Yoshioka, R. Matsushima-Nishiwaki, H. Tsurumi, K. Ito, S. L. Friedman, H. Moriwaki, et al.
The RING Finger Protein, RNF8, Interacts with Retinoid X Receptor {alpha} and Enhances Its Transcription-stimulating Activity
J. Biol. Chem., April 30, 2004; 279(18): 18926 - 18934.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
B. R. Haugen, L. L. Larson, U. Pugazhenthi, W. R. Hays, J. P. Klopper, C. A. Kramer, and V. Sharma
Retinoic Acid and Retinoid X Receptors Are Differentially Expressed in Thyroid Cancer and Thyroid Carcinoma Cell Lines and Predict Response to Treatment with Retinoids
J. Clin. Endocrinol. Metab., January 1, 2004; 89(1): 272 - 280.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
L. Wang, A. Hoque, R. Z. Luo, J. Yuan, Z. Lu, A. Nishimoto, J. Liu, A. A. Sahin, S. M. Lippman, R. C. Bast Jr., et al.
Loss of the Expression of the Tumor Suppressor Gene ARHI Is Associated with Progression of Breast Cancer
Clin. Cancer Res., September 1, 2003; 9(10): 3660 - 3666.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
R. Matsushima-Nishiwaki, M. Okuno, Y. Takano, S. Kojima, S. L. Friedman, and H. Moriwaki
Molecular mechanism for growth suppression of human hepatocellular carcinoma cells by acyclic retinoid
Carcinogenesis, August 1, 2003; 24(8): 1353 - 1359.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Esteller, M. Guo, V. Moreno, M. A. Peinado, G. Capella, O. Galm, S. B. Baylin, and J. G. Herman
Hypermethylation-associated Inactivation of the Cellular Retinol-Binding-Protein 1 Gene in Human Cancer
Cancer Res., October 15, 2002; 62(20): 5902 - 5905.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. I. Chen, K. M. Sommer, and K. Swisshelm
Downstream Codons in the Retinoic Acid Receptor beta -2 and beta -4 mRNAs Initiate Translation of a Protein Isoform That Disrupts Retinoid-activated Transcription
J. Biol. Chem., September 13, 2002; 277(38): 35411 - 35421.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. Huang, W. C. Powell, A. C. Khodavirdi, J. Wu, T. Makita, R. D. Cardiff, M. B. Cohen, H. M. Sucov, and P. Roy-Burman
Prostatic Intraepithelial Neoplasia in Mice with Conditional Disruption of the Retinoid X Receptor{alpha} Allele in the Prostate Epithelium
Cancer Res., August 15, 2002; 62(16): 4812 - 4819.
[Abstract] [Full Text] [PDF]

Home page
 Cell Growth Differ.Home page
E. F. Farias, A. Arapshian, I. J. Bleiweiss, S. Waxman, A. Zelent, and R. Mira-y-Lopez
Retinoic Acid Receptor {alpha}2 Is a Growth Suppressor Epigenetically Silenced In MCF-7 Human Breast Cancer Cells
Cell Growth Differ., August 1, 2002; 13(8): 335 - 341.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. M. Sirchia, M. Ren, R. Pili, E. Sironi, G. Somenzi, R. Ghidoni, S. Toma, G. Nicolo, and N. Sacchi
Endogenous Reactivation of the RAR{beta}2 Tumor Suppressor Gene Epigenetically Silenced in Breast Cancer
Cancer Res., May 1, 2002; 62(9): 2455 - 2461.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
B. N. Rexer, W. Li Zheng, and D. E. Ong
Retinoic Acid Biosynthesis by Normal Human Breast Epithelium Is via Aldehyde Dehydrogenase 6, Absent in MCF-7 Cells
Cancer Res., October 1, 2001; 61(19): 7065 - 7070.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
X.-C. Xu, W. Y. L. Wong, L. Goldberg, S. C. Baer, J. E. Wolf, W. M. Ramsdell, D. S. Alberts, S. M. Lippman, and R. Lotan
Progressive Decreases in Nuclear Retinoid Receptors during Skin Squamous Carcinogenesis
Cancer Res., June 1, 2001; 61(11): 4306 - 4310.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
X. Guo, D. M Nanus, A. Ruiz, R. R Rando, D. Bok, and L. J Gudas
Reduced Levels of Retinyl Esters and Vitamin A in Human Renal Cancers
Cancer Res., March 1, 2001; 61(6): 2774 - 2781.
[Abstract] [Full Text]

Home page
 Cancer Res.Home page
H. Wan, W. K. Hong, and R. Lotan
Increased Retinoic Acid Responsiveness in Lung Carcinoma Cells that Are Nonresponsive Despite the Presence of Endogenous Retinoic Acid Receptor (RAR) {beta} by Expression of Exogenous Retinoid Receptors Retinoid X Receptor {{alpha}}, RAR{{alpha}}, and RAR{{gamma}}
Cancer Res., January 1, 2001; 61(2): 556 - 564.
[Abstract] [Full Text]

Home page
 Am. J. Pathol.Home page
Q. Yang, I. Mori, L. Shan, M. Nakamura, Y. Nakamura, H. Utsunomiya, G. Yoshimura, T. Suzuma, T. Tamaki, T. Umemura, et al.
Biallelic Inactivation of Retinoic Acid Receptor {beta}2 Gene by Epigenetic Change in Breast Cancer
Am. J. Pathol., January 1, 2001; 158(1): 299 - 303.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
X. Guo, A. Ruiz, R. R. Rando, D. Bok, and L. J. Gudas
Esterification of all-trans-retinol in normal human epithelial cell strains and carcinoma lines from oral cavity, skin and breast: reduced expression of lecithin:retinol acyltransferase in carcinoma lines
Carcinogenesis, November 1, 2000; 21(11): 1925 - 1933.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
W. K. Hong, M. R. Spitz, and S. M. Lippman
Cancer Chemoprevention in the 21st Century: Genetics, Risk Modeling, and Molecular Targets
J. Clin. Oncol., November 1, 2000; 18(90001): 9s - 18.
[Full Text] [PDF]

Home page
 BloodHome page
R. A. Finch, J. Li, T-C. Chou, and A. C. Sartorelli
Maintenance of retinoic acid receptor alpha pools by granulocyte colony-stimulating factor and lithium chloride in all-trans retinoic acid-treated WEHI-3B leukemia cells: relevance to the synergistic induction of terminal differentiation
Blood, September 15, 2000; 96(6): 2262 - 2268.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
A. TOULOUSE, M. LOUBEAU, J. MORIN, J. J. PAPPAS, J. WU, and W. E. C. BRADLEY
RAR{beta} involvement in enhancement of lung tumor cell immunogenicity revealed by array analysis
FASEB J, June 1, 2000; 14(9): 1224 - 1232.
[Abstract] [Full Text]

Home page
 Cancer Res.Home page
F. Lin, D. Xiao, S. K. Kolluri, and X.-k. Zhang
Unique Anti-Activator Protein-1 Activity of Retinoic Acid Receptor {beta}
Cancer Res., June 1, 2000; 60(12): 3271 - 3280.
[Abstract] [Full Text]

Home page
 JNCI J Natl Cancer InstHome page
M. B. Sporn
Retinoids and Demethylating Agents-- Looking for Partners
J Natl Cancer Inst, May 17, 2000; 92(10): 780 - 781.
[Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
M. Widschwendter, J. Berger, M. Hermann, H. M. Muller, A. Amberger, M. Zeschnigk, A. Widschwendter, B. Abendstein, A. G. Zeimet, G. Daxenbichler, et al.
Methylation and Silencing of the Retinoic Acid Receptor-{beta}2 Gene in Breast Cancer
J Natl Cancer Inst, May 17, 2000; 92(10): 826 - 832.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
M. J. Spinella and E. Dmitrovsky
Aberrant Retinoid Signaling and Breast Cancer: the View From Outside the Nucleus
J Natl Cancer Inst, March 15, 2000; 92(6): 438 - 440.
[Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
Y. S. Kuppumbatti, I. J. Bleiweiss, J. P. Mandeli, S. Waxman, and R. Mira-y-Lopez
Cellular Retinol-Binding Protein Expression and Breast Cancer
J Natl Cancer Inst, March 15, 2000; 92(6): 475 - 480.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
B. Lin, G.-q. Chen, D. Xiao, S. K. Kolluri, X. Cao, H. Su, and X.-k. Zhang
Orphan Receptor COUP-TF Is Required for Induction of Retinoic Acid Receptor beta , Growth Inhibition, and Apoptosis by Retinoic Acid in Cancer Cells
Mol. Cell. Biol., February 1, 2000; 20(3): 957 - 970.
[Abstract] [Full Text]

Home page
 JNCI J Natl Cancer InstHome page
S. M. Lippman and P. H. Brown
Tamoxifen Prevention of Breast Cancer: an Instance of the Fingerpost
J Natl Cancer Inst, November 3, 1999; 91(21): 1809 - 1819.
[Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
H. Qiu, W. Zhang, A. K. El-Naggar, S. M. Lippman, P. Lin, R. Lotan, and X.-C. Xu
Loss of Retinoic Acid Receptor-{beta} Expression Is an Early Event during Esophageal Carcinogenesis
Am. J. Pathol., November 1, 1999; 155(5): 1519 - 1523.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. N. Faria, C. Mendelsohn, P. Chambon, and L. J. Gudas
The Targeted Disruption of Both Alleles of RARbeta 2 in F9 Cells Results in the Loss of Retinoic Acid-associated Growth Arrest
J. Biol. Chem., September 17, 1999; 274(38): 26783 - 26788.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
R. K. Srivastava, A. R. Srivastava, Y. S. Cho-Chung, and D. L. Longo
Synergistic Effects of Retinoic Acid and 8-Chloro-Adenosine 3',5'-Cyclic Monophosphate on the Regulation of Retinoic Acid Receptor {beta} and Apoptosis: Involvement of Mitochondria
Clin. Cancer Res., July 1, 1999; 5(7): 1892 - 1904.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
E. Picard, C. Seguin, N. Monhoven, C. Rochette-Egly, J. Siat, J. Borrelly, Y. Martinet, N. Martinet, and J. M. Vignaud
Expression of Retinoid Receptor Genes and Proteins in Non-Small-Cell Lung Cancer
J Natl Cancer Inst, June 16, 1999; 91(12): 1059 - 1066.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
X.-C. Xu, X. Liu, E. Tahara, S. M. Lippman, and R. Lotan
Expression and Up-Regulation of Retinoic Acid Receptor-{beta} Is Associated with Retinoid Sensitivity and Colony Formation in Esophageal Cancer Cell Lines
Cancer Res., May 1, 1999; 59(10): 2477 - 2483.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
J. O. Boyle, J. Langenfeld, F. Lonardo, D. Sekula, P. Reczek, V. Rusch, M. I. Dawson, and E. Dmitrovsky
Cyclin D1 Proteolysis: a Retinoid Chemoprevention Signal in Normal, Immortalized, and Transformed Human Bronchial Epithelial Cells
J Natl Cancer Inst, February 17, 1999; 91(4): 373 - 379.
[Abstract] [Full Text] [PDF]

Home page
 Cell Growth Differ.Home page
V. L. Seewaldt, E. C. Dietze, B. S. Johnson, S. J. Collins, and M. B. Parker
Retinoic Acid-mediated G1-S-Phase Arrest of Normal Human Mammary Epithelial Cells Is Independent of the Level of p53 Protein Expression
Cell Growth Differ., January 1, 1999; 10(1): 49 - 59.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
H.-Y. Lee, Y.-A. Suh, M. J. Robinson, J. L. Clifford, W. K. Hong, J. R. Woodgett, M. H. Cobb, D. J. Mangelsdorf, and J. M. Kurie
Stress Pathway Activation Induces Phosphorylation of Retinoid X Receptor
J. Biol. Chem., October 6, 2000; 275(41): 32193 - 32199.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 1997 by the American Association for Cancer Research.