Cancer Research Infection and Cancer: Biology, Therapeutics, and Prevention  Tumor Immunology: New Perspectives
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online

[Cancer Research 57, 4997-5000, November 15, 1997]
© 1997 American Association for Cancer Research

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cairns, P.
Right arrow Articles by Sidransky, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cairns, P.
Right arrow Articles by Sidransky, D.

Frequent Inactivation of PTEN/MMAC1 in Primary Prostate Cancer

Paul Cairns, Kenji Okami, Sarel Halachmi, Naomi Halachmi, Manel Esteller, James G. Herman, Jin Jen, W. B. Isaacs, G. Steven Bova and David Sidransky1

Head and Neck Cancer Research, Department of Otolaryngology [P. C., K. O., S. H., N. H., J. J., D. S.], Oncology Center [M. E., J. G. H., W. B. I., D. S.], Departments of Urology [W. B. I.] and Pathology [G. S. B.], Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

Sporadic prostate carcinoma is the most common male cancer in the Western world, yet many of the major genetic events involved in the progression of this often fatal cancer remain to be elucidated. Numerous cytogenetic and allelotype studies have reported frequent loss of heterozygosity on chromosomal arm 10q in sporadic prostate cancer. Deletion mapping studies have unambiguously identified a region of chromosome 10q23 to be the minimal area of loss. A new tumor suppressor gene, PTEN/MMAC1, was isolated recently at this region of chromosome 10q23 and found to be inactivated by mutation in three prostate cancer cell lines. We screened 80 prostate tumors by microsatellite analysis and found chromosome 10q23 to be deleted in 23 cases. We then proceeded with sequence analysis of the entire PTEN/MMAC1 coding region and tested for homozygous deletion with new intragenic markers in these 23 cases with 10q23 loss of heterozygosity. The identification of the second mutational event in 10 (43%) tumors establishes PTEN/MMAC1 as a main inactivation target of 10q loss in sporadic prostate cancer.

1 To whom requests for reprints should be addressed, at Department of Otolaryngology-Head and Neck Surgery, Head and Neck Cancer Research Division, Johns Hopkins University School of Medicine, 818 Ross Research Building, 720 Rutland Avenue, Baltimore, MD 21205-2196.

Received 9/12/97. Accepted 10/ 2/97.




This article has been cited by other articles:


Home page
Molecular Cancer TherapeuticsHome page
A. Tomioka, M. Tanaka, M. A. De Velasco, S. Anai, S. Takada, T. Kushibiki, Y. Tabata, C. J. Rosser, H. Uemura, and Y. Hirao
Delivery of PTEN via a novel gene microcapsule sensitizes prostate cancer cells to irradiation
Mol. Cancer Ther., July 1, 2008; 7(7): 1864 - 1870.
[Abstract] [Full Text] [PDF]


Home page
Molecular Cancer TherapeuticsHome page
Y. Takei, Y. Saga, H. Mizukami, T. Takayama, M. Ohwada, K. Ozawa, and M. Suzuki
Overexpression of PTEN in ovarian cancer cells suppresses i.p. dissemination and extends survival in mice
Mol. Cancer Ther., March 1, 2008; 7(3): 704 - 711.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
B. M. Emerling, F. Weinberg, J.-L. Liu, T. W. Mak, and N. S. Chandel
PTEN regulates p300-dependent hypoxia-inducible factor 1 transcriptional activity through Forkhead transcription factor 3a (FOXO3a)
PNAS, February 19, 2008; 105(7): 2622 - 2627.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
R. Bedolla, T. J. Prihoda, J. I. Kreisberg, S. N. Malik, N. K. Krishnegowda, D. A. Troyer, and P. M. Ghosh
Determining Risk of Biochemical Recurrence in Prostate Cancer by Immunohistochemical Detection of PTEN Expression and Akt Activation
Clin. Cancer Res., July 1, 2007; 13(13): 3860 - 3867.
[Abstract] [Full Text] [PDF]


Home page
Sci SignalHome page
J. J. Zhao and T. M. Roberts
PI3 Kinases in Cancer: From Oncogene Artifact to Leading Cancer Target
Sci. Signal., December 12, 2006; 2006(365): pe52 - pe52.
[Abstract] [Full Text] [PDF]


Home page
Mol. Endocrinol.Home page
Z. Dong, Y. Liu, S. Lu, A. Wang, K. Lee, L.-H. Wang, M. Revelo, and S. Lu
Vav3 Oncogene Is Overexpressed and Regulates Cell Growth and Androgen Receptor Activity in Human Prostate Cancer
Mol. Endocrinol., October 1, 2006; 20(10): 2315 - 2325.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
K. S. R. Sastry, Y. Karpova, and G. Kulik
Epidermal Growth Factor Protects Prostate Cancer Cells from Apoptosis by Inducing BAD Phosphorylation via Redundant Signaling Pathways
J. Biol. Chem., September 15, 2006; 281(37): 27367 - 27377.
[Abstract] [Full Text] [PDF]


Home page
Ann. N. Y. Acad. Sci.Home page
J. PUC, G. PLACHA, B. WOCIAL, K. PODSYPANINA, R. PARSONS, and Z. GACIONG
Analysis of PTEN Mutation in Non-familial Pheochromocytoma.
Ann. N.Y. Acad. Sci., August 1, 2006; 1073: 317 - 331.
[Abstract] [Full Text] [PDF]


Home page
Cancer Epidemiol. Biomarkers Prev.Home page
C. A. Haiman, D. O. Stram, I. Cheng, E. E. Giorgi, L. Pooler, K. Penney, L. Le Marchand, B. E. Henderson, and M. L. Freedman
Common Genetic Variation at PTEN and Risk of Sporadic Breast and Prostate Cancer.
Cancer Epidemiol. Biomarkers Prev., May 1, 2006; 15(5): 1021 - 1025.
[Abstract] [Full Text] [PDF]


Home page
Molecular Cancer TherapeuticsHome page
D. Koul, R. Shen, S. Bergh, X. Sheng, S. Shishodia, T. A. Lafortune, Y. Lu, J. F. de Groot, G. B. Mills, and W.K. A. Yung
Inhibition of Akt survival pathway by a small-molecule inhibitor in human glioblastoma.
Mol. Cancer Ther., March 1, 2006; 5(3): 637 - 644.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
L. I. Yoo, D. W. Liu, S. L. Vu, R. T. Bronson, H. Wu, and J. Yuan
Pten Deficiency Activates Distinct Downstream Signaling Pathways in a Tissue-Specific Manner
Cancer Res., February 15, 2006; 66(4): 1929 - 1939.
[Abstract] [Full Text] [PDF]


Home page
Molecular Cancer TherapeuticsHome page
Y. Wu, K. Zu, M. A. Warren, P. K. Wallace, and C. Ip
Delineating the mechanism by which selenium deactivates Akt in prostate cancer cells.
Mol. Cancer Ther., February 1, 2006; 5(2): 246 - 252.
[Abstract] [Full Text] [PDF]


Home page
JCOHome page
H. I. Scher and C. L. Sawyers
Biology of Progressive, Castration-Resistant Prostate Cancer: Directed Therapies Targeting the Androgen-Receptor Signaling Axis
J. Clin. Oncol., November 10, 2005; 23(32): 8253 - 8261.
[Abstract] [Full Text] [PDF]


Home page
Hum Mol GenetHome page
S. Agrawal, R. Pilarski, and C. Eng
Different splicing defects lead to differential effects downstream of the lipid and protein phosphatase activities of PTEN
Hum. Mol. Genet., August 15, 2005; 14(16): 2459 - 2468.
[Abstract] [Full Text] [PDF]


Home page
CarcinogenesisHome page
H. Hu, C. Jiang, G. Li, and J. Lu
PKB/AKT and ERK regulation of caspase-mediated apoptosis by methylseleninic acid in LNCaP prostate cancer cells
Carcinogenesis, August 1, 2005; 26(8): 1374 - 1381.
[Abstract] [Full Text] [PDF]


Home page
Genes Dev.Home page
L. Ma, J. Teruya-Feldstein, N. Behrendt, Z. Chen, T. Noda, O. Hino, C. Cordon-Cardo, and P. P. Pandolfi
Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor suppression
Genes & Dev., August 1, 2005; 19(15): 1779 - 1786.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
X. Ma, A. C. Ziel-van der Made, B. Autar, H. A. van der Korput, M. Vermeij, P. van Duijn, K. B. Cleutjens, R. de Krijger, P. Krimpenfort, A. Berns, et al.
Targeted Biallelic Inactivation of Pten in the Mouse Prostate Leads to Prostate Cancer Accompanied by Increased Epithelial Cell Proliferation but not by Reduced Apoptosis
Cancer Res., July 1, 2005; 65(13): 5730 - 5739.
[Abstract] [Full Text] [PDF]


Home page
Molecular Cancer TherapeuticsHome page
Y. Luo, A. R. Shoemaker, X. Liu, K. W. Woods, S. A. Thomas, R. de Jong, E. K. Han, T. Li, V. S. Stoll, J. A. Powlas, et al.
Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo
Mol. Cancer Ther., June 1, 2005; 4(6): 977 - 986.
[Abstract] [Full Text] [PDF]


Home page
aacredbookHome page
W. E. Grizzle, D. G. Bostwick, H. Burke, O. W. Tawfik, D. McGregor, J. Cohn, and R. Lieberman
Biomarkers in Prostate Cancer
Am. Assoc. Cancer Res. Educ. Book, April 1, 2005; 2005(1): 196 - 204.
[Full Text] [PDF]


Home page
Cancer Res.Home page
R. Berger, P. G. Febbo, P. K. Majumder, J. J. Zhao, S. Mukherjee, S. Signoretti, K. T. Campbell, W. R. Sellers, T. M. Roberts, M. Loda, et al.
Androgen-Induced Differentiation and Tumorigenicity of Human Prostate Epithelial Cells
Cancer Res., December 15, 2004; 64(24): 8867 - 8875.
[Abstract] [Full Text] [PDF]


Home page
EndocrinologyHome page
G. Tell, A. Pines, F. Arturi, L. Cesaratto, E. Adamson, C. Puppin, I. Presta, D. Russo, S. Filetti, and G. Damante
Control of Phosphatase and Tensin Homolog (PTEN) Gene Expression in Normal and Neoplastic Thyroid Cells
Endocrinology, October 1, 2004; 145(10): 4660 - 4666.
[Abstract] [Full Text] [PDF]


Home page
Endocr Relat CancerHome page
R. Foley, D. Hollywood, and M. Lawler
Molecular pathology of prostate cancer: the key to identifying new biomarkers of disease
Endocr. Relat. Cancer, September 1, 2004; 11(3): 477 - 488.
[Abstract] [Full Text] [PDF]


Home page
JCOHome page
I. Sansal and W. R. Sellers
The Biology and Clinical Relevance of the PTEN Tumor Suppressor Pathway
J. Clin. Oncol., July 15, 2004; 22(14): 2954 - 2963.
[Abstract] [Full Text] [PDF]


Home page
Endocr. Rev.Home page
C. A. Heinlein and C. Chang
Androgen Receptor in Prostate Cancer
Endocr. Rev., April 1, 2004; 25(2): 276 - 308.
[Abstract] [Full Text] [PDF]


Home page
Mol Hum ReprodHome page
W.A. Schulz, M. Burchardt, and M.V. Cronauer
Molecular biology of prostate cancer
Mol. Hum. Reprod., August 1, 2003; 9(8): 437 - 448.
[Abstract] [Full Text] [PDF]


Home page
NEJMHome page
W. G. Nelson, A. M. De Marzo, and W. B. Isaacs
Prostate Cancer
N. Engl. J. Med., July 24, 2003; 349(4): 366 - 381.
[Full Text] [PDF]


Home page
J. Biol. Chem.Home page
C.-C. Yang, H.-P. Lin, C.-S. Chen, Y.-T. Yang, P.-H. Tseng, V. M. Rangnekar, and C.-S. Chen
Bcl-xL Mediates a Survival Mechanism Independent of the Phosphoinositide 3-Kinase/Akt Pathway in Prostate Cancer Cells
J. Biol. Chem., July 3, 2003; 278(28): 25872 - 25878.
[Abstract] [Full Text] [PDF]


Home page
Physiol. Rev.Home page
M. Mareel and A. Leroy
Clinical, Cellular, and Molecular Aspects of Cancer Invasion
Physiol Rev, April 1, 2003; 83(2): 337 - 376.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
O. J. Halvorsen, S. A. Haukaas, and L. A. Akslen
Combined Loss of PTEN and p27 Expression Is Associated with Tumor Cell Proliferation by Ki-67 and Increased Risk of Recurrent Disease in Localized Prostate Cancer
Clin. Cancer Res., April 1, 2003; 9(4): 1474 - 1479.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
V. Modur, R. Nagarajan, B. M. Evers, and J. Milbrandt
FOXO Proteins Regulate Tumor Necrosis Factor-related Apoptosis Inducing Ligand Expression. IMPLICATIONS FOR PTEN MUTATION IN PROSTATE CANCER
J. Biol. Chem., November 27, 2002; 277(49): 47928 - 47937.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Pathol.Home page
L. D. True, K. Buhler, J. Quinn, E. Williams, P. S. Nelson, N. Clegg, J. A. Macoska, T. Norwood, A. Liu, W. Ellis, et al.
A Neuroendocrine/Small Cell Prostate Carcinoma Xenograft--LuCaP 49
Am. J. Pathol., August 1, 2002; 161(2): 705 - 715.
[Abstract] [Full Text] [PDF]


Home page
J. Gen. Virol.Home page
S. Sun and B. M. Steinberg
PTEN is a negative regulator of STAT3 activation in human papillomavirus-infected cells
J. Gen. Virol., June 1, 2002; 83(7): 1651 - 1658.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
M. Fernandez and C. Eng
The Expanding Role of PTEN in Neoplasia: A Molecule for All Seasons? : Commentary re: M. A. Davies, et al., Adenoviral-mediated Expression of MMAC/PTEN Inhibits Proliferation and Metastasis of Human Prostate Cancer Cells. Clin. Cancer Res., 8: 1904-1914, 2002.
Clin. Cancer Res., June 1, 2002; 8(6): 1695 - 1698.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
M. A. Davies, S. J. Kim, N. U. Parikh, Z. Dong, C. D. Bucana, and G. E. Gallick
Adenoviral-mediated Expression of MMAC/PTEN Inhibits Proliferation and Metastasis of Human Prostate Cancer Cells
Clin. Cancer Res., June 1, 2002; 8(6): 1904 - 1914.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
J.-C. Soria, H.-Y. Lee, J. I. Lee, L. Wang, J.-P. Issa, B. L. Kemp, D. D. Liu, J. M. Kurie, L. Mao, and F. R. Khuri
Lack of PTEN Expression in Non-Small Cell Lung Cancer Could Be Related to Promoter Methylation
Clin. Cancer Res., May 1, 2002; 8(5): 1178 - 1184.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Pathol.Home page
N. Tsuchiya, Y. Kondo, A. Takahashi, H. Pawar, J. Qian, K. Sato, M. M. Lieber, and R. B. Jenkins
Mapping and Gene Expression Profile of the Minimally Overrepresented 8q24 Region in Prostate Cancer
Am. J. Pathol., May 1, 2002; 160(5): 1799 - 1806.
[Abstract] [Full Text] [PDF]


Home page
Endocr. Rev.Home page
C. A. Heinlein and C. Chang
Androgen Receptor (AR) Coregulators: An Overview
Endocr. Rev., April 1, 2002; 23(2): 175 - 200.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
L. Zhuang, J. Lin, M. L. Lu, K. R. Solomon, and M. R. Freeman
Cholesterol-rich Lipid Rafts Mediate Akt-regulated Survival in Prostate Cancer Cells
Cancer Res., April 1, 2002; 62(8): 2227 - 2231.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Pathol.Home page
N. Konishi, M. Nakamura, M. Kishi, M. Nishimine, E. Ishida, and K. Shimada
Heterogeneous Methylation and Deletion Patterns of the INK4a/ARF Locus Within Prostate Carcinomas
Am. J. Pathol., April 1, 2002; 160(4): 1207 - 1214.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
M. Ichinose, X.-H. Liu, N. Hagihara, and R. J. Youle
Extracellular Bad Fused to Toxin Transport Domains Induces Apoptosis
Cancer Res., March 1, 2002; 62(5): 1433 - 1438.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Pathol.Home page
M. A. Zysman, W. B. Chapman, and B. Bapat
Considerations When Analyzing the Methylation Status of PTEN Tumor Suppressor Gene
Am. J. Pathol., March 1, 2002; 160(3): 795 - 800.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
I. Vancurova, R. Wu, V. Miskolci, and S. Sun
Increased p50/p50 NF-{kappa}B Activation in Human Papillomavirus Type 6- or Type 11-Induced Laryngeal Papilloma Tissue
J. Virol., February 1, 2002; 76(3): 1533 - 1536.
[Abstract] [Full Text] [PDF]


Home page
Arch Otolaryngol Head Neck SurgHome page
J. I. Lee, J.-C. Soria, K. A. Hassan, A. K. El-Naggar, X. Tang, D. D. Liu, W. K. Hong, and L. Mao
Loss of PTEN Expression as a Prognostic Marker for Tongue Cancer
Arch Otolaryngol Head Neck Surg, December 1, 2001; 127(12): 1441 - 1445.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
G. Dicuonzo, S. Angeletti, J. Garcia-Foncillas, A. Brugarolas, Y. Okrouzhnov, D. Santini, G. Tonini, G. Lorino, M. De Cesaris, and A. Baldi
Colorectal Carcinomas and PTEN/MMAC1 Gene Mutations
Clin. Cancer Res., December 1, 2001; 7(12): 4049 - 4053.
[Abstract] [Full Text] [PDF]


Home page
JNCI J Natl Cancer InstHome page
M. E. Grossmann, H. Huang, and D. J. Tindall
Androgen Receptor Signaling in Androgen-Refractory Prostate Cancer
J Natl Cancer Inst, November 21, 2001; 93(22): 1687 - 1697.
[Abstract] [Full Text] [PDF]


Home page
JNCI J Natl Cancer InstHome page
C. Jeronimo, H. Usadel, R. Henrique, J. Oliveira, C. Lopes, W. G. Nelson, and D. Sidransky
Quantitation of GSTP1 Methylation in Non-neoplastic Prostatic Tissue and Organ-Confined Prostate Adenocarcinoma
J Natl Cancer Inst, November 21, 2001; 93(22): 1747 - 1752.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
H. Thakkar, X. Chen, F. Tyan, S. Gim, H. Robinson, C. Lee, S. K. Pandey, C. Nwokorie, N. Onwudiwe, and R. K. Srivastava
Pro-survival Function of Akt/Protein Kinase B in Prostate Cancer Cells. RELATIONSHIP WITH TRAIL RESISTANCE
J. Biol. Chem., October 12, 2001; 276(42): 38361 - 38369.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
H. Huang, J. C. Cheville, Y. Pan, P. C. Roche, L. J. Schmidt, and D. J. Tindall
PTEN Induces Chemosensitivity in PTEN-mutated Prostate Cancer Cells by Suppression of Bcl-2 Expression
J. Biol. Chem., October 12, 2001; 276(42): 38830 - 38836.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
B. Kwabi-Addo, D. Giri, K. Schmidt, K. Podsypanina, R. Parsons, N. Greenberg, and M. Ittmann
Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progression
PNAS, September 5, 2001; (2001) 201167798.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
T. Minaguchi, H. Yoshikawa, K. Oda, T. Ishino, T. Yasugi, T. Onda, S. Nakagawa, K. Matsumoto, K. Kawana, and Y. Taketani
PTEN Mutation Located Only Outside Exons 5, 6, and 7 Is an Independent Predictor of Favorable Survival in Endometrial Carcinomas
Clin. Cancer Res., September 1, 2001; 7(9): 2636 - 2642.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
P. Cairns, M. Esteller, J. G. Herman, M. Schoenberg, C. Jeronimo, M. Sanchez-Cespedes, N.-H. Chow, M. Grasso, L. Wu, W. B. Westra, et al.
Molecular Detection of Prostate Cancer in Urine by GSTP1 Hypermethylation
Clin. Cancer Res., September 1, 2001; 7(9): 2727 - 2730.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
K. Kimura, M. Markowski, C. Bowen, and E. P. Gelmann
Androgen Blocks Apoptosis of Hormone-dependent Prostate Cancer Cells
Cancer Res., July 1, 2001; 61(14): 5611 - 5618.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Pathol.Home page
H. Sasaki, M. C. Zlatescu, R. A. Betensky, Y. Ino, J. G. Cairncross, and D. N. Louis
PTEN Is a Target of Chromosome 10q Loss in Anaplastic Oligodendrogliomas and PTEN Alterations Are Associated with Poor Prognosis
Am. J. Pathol., July 1, 2001; 159(1): 359 - 367.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
X. Zhu, C.-H. Kwon, P. W. Schlosshauer, L. H. Ellenson, and S. J. Baker
PTEN Induces G1 Cell Cycle Arrest and Decreases Cyclin D3 Levels in Endometrial Carcinoma Cells
Cancer Res., June 1, 2001; 61(11): 4569 - 4575.
[Abstract] [Full Text] [PDF]


Home page
J. Med. Genet.Home page
J. F Costello and C. Plass
Methylation matters
J. Med. Genet., May 1, 2001; 38(5): 285 - 303.
[Abstract] [Full Text]


Home page
Cancer Epidemiol. Biomarkers Prev.Home page
D. J. George, T. F. Shepard, J. Ma, E. Giovannucci, P. W. Kantoff, and M. J. Stampfer
PTEN Polymorphism (IVS4) Is Not Associated with Risk of Prostate Cancer
Cancer Epidemiol. Biomarkers Prev., April 1, 2001; 10(4): 411 - 412.
[Full Text]


Home page
Cancer Res.Home page
G. Kulik, J. P. Carson, T. Vomastek, K. Overman, B. D. Gooch, S. Srinivasula, E. Alnemri, G. Nunez, and M. J. Weber
Tumor Necrosis Factor {{alpha}} Induces BID Cleavage and Bypasses Antiapoptotic Signals in Prostate Cancer LNCaP Cells
Cancer Res., March 1, 2001; 61(6): 2713 - 2719.
[Abstract] [Full Text]


Home page
Clin. Cancer Res.Home page
J.-T. Dong, C.-L. Li, T. W. Sipe, and H. F. Frierson Jr.
Mutations of PTEN/MMAC1 in Primary Prostate Cancers from Chinese Patients
Clin. Cancer Res., February 1, 2001; 7(2): 304 - 308.
[Abstract] [Full Text]


Home page
Mol. Cell. Biol.Home page
N. Nakamura, S. Ramaswamy, F. Vazquez, S. Signoretti, M. Loda, and W. R. Sellers
Forkhead Transcription Factors Are Critical Effectors of Cell Death and Cell Cycle Arrest Downstream of PTEN
Mol. Cell. Biol., December 1, 2000; 20(23): 8969 - 8982.
[Abstract] [Full Text]


Home page
Am. J. Pathol.Home page
X.-P. Zhou, O. Gimm, H. Hampel, T. Niemann, M. J. Walker, and C. Eng
Epigenetic PTEN Silencing in Malignant Melanomas without PTEN Mutation
Am. J. Pathol., October 1, 2000; 157(4): 1123 - 1128.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
H. Kato, S. Kato, T. Kumabe, Y. Sonoda, T. Yoshimoto, S. Kato, S.-Y. Han, T. Suzuki, H. Shibata, R. Kanamaru, et al.
Functional Evaluation of p53 and PTEN Gene Mutations in Gliomas
Clin. Cancer Res., October 1, 2000; 6(10): 3937 - 3943.