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[Cancer Research 57, 5207-5212, December 1, 1997]
© 1997 American Association for Cancer Research
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Absence of Fhit Protein in Primary Lung Tumors and Cell Lines with FHIT Gene Abnormalities1

Gabriella Sozzi2, Silvana Tornielli, Elda Tagliabue, Laura Sard, Francesco Pezzella, Ugo Pastorino, Fabiola Minoletti, Silvana Pilotti, Cathy Ratcliffe, Maria Luisa Veronese, Peter Goldstraw, Kay Huebner, Carlo M. Croce and Marco A. Pierotti

Division of Experimental Oncology A [G. S., S. T., L. S., F. M., M. A. P.] and E [E. T.], Anatomical Pathology [S. P.], Istituto Nazionale Tumori, Via Venezian 1, 20133 Milan, Italy; Royal Brompton Hospital, London, United Kingdom [U. P., C. R., P. G.]; University College of London, London, United Kingdom [F. P.]; and Kimmel Cancer Center, Jefferson Medical College, Philadelphia, Pennsylvania 19107 [M. L. V., K. H., C. M. C.]

Genomic alterations and abnormal expression of the FHIT gene at 3p14.2 have been observed in cell lines and primary tumors of the lung. To correlate FHIT locus DNA and RNA lesions with effects on Fhit protein expression, we have analyzed 11 lung cancer cell lines, 15 small cell lung carcinomas, and 38 pairs of non-small cell primary tumors and bronchial mucosa specimens by molecular genetic and immunocytochemical methods. Using specific antibodies against the Fhit protein, we observed concordance between RNA abnormalities and lack of Fhit protein expression in lung tumors and cell lines. In addition, absence of Fhit protein in some precancerous dysplastic lesions suggested that FHIT inactivation may occur at an early phase of lung carcinogenesis.

1 This work was supported by grants from the Italian Association for Cancer Research, The Italian National Research Council, and by USPHS Grants CA21124 and CA56336. L. S. is an Italian Association for Cancer Research Fellow.

2 To whom requests for reprints should be addressed. Phone: 39-2-2390232; Fax: 39-2-2390764; E-mail: sozzi@istitutotumori.mi.it.

Received 9/15/97. Accepted 10/17/97.




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HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 1997 by the American Association for Cancer Research.