Cancer Research AACR Legacy  Protein Translation and Cancer
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online

[Cancer Research 57, 5328-5335, December 1, 1997]
© 1997 American Association for Cancer Research

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jiang, B.-H.
Right arrow Articles by Semenza, G. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jiang, B.-H.
Right arrow Articles by Semenza, G. L.

V-SRC Induces Expression of Hypoxia-inducible Factor 1 (HIF-1) and Transcription of Genes Encoding Vascular Endothelial Growth Factor and Enolase 1: Involvement of HIF-1 in Tumor Progression1

Bing-Hua Jiang, Faton Agani, Antonino Passaniti and Gregg L. Semenza2

Center for Medical Genetics, Departments of Pediatrics and Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-3914 [B-H. J., F. A., G. L. S.], and National Institute on Aging, NIH, Baltimore, Maryland 21224 [A. P.]

Adaptation to hypoxia represents an important aspect of tumor progression. Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that mediates essential homeostatic responses to cellular and systemic hypoxia by activating transcription of multiple genes including those encoding glycolytic enzymes and vascular endothelial growth factor (VEGF). In this report, we demonstrate that whereas C-SRC expression is not required for expression of HIF-1 or transcriptional activation of genes encoding VEGF and enolase 1 (ENO1), cells expressing the v-Src oncogene have increased expression of HIF-1, VEGF, and ENO1 under both hypoxic and nonhypoxic conditions. Expression of V-SRC was associated with increased transcription of reporter genes containing cis-acting hypoxia-response elements from the VEGF and ENO1 genes, and this transcriptional activation required an intact HIF-1 binding site. When three rat hepatoma subclones that differed with respect to the level of HIF-1 expression were injected into nude mice, tumor growth correlated with HIF-1 expression, suggesting that HIF-1 may be generally involved in tumor progression. These studies link an oncogene to the induction of HIF-1 expression, thus providing a mechanism for hypoxic adaptation by tumor cells.

1 This work was supported by grants from the American Heart Association National Center and National Institutes of Health (R01-HL55338 and R01-DK39869). G. L. S. is an Established Investigator of the American Heart Association.

2 To whom requests for reprints should be addressed, at Center for Medical Genetics, Johns Hopkins Hospital, CMSC-1004, 600 North Wolfe Street, Baltimore, MD 21287-3914. Phone: (410) 955-1619; Fax: (410) 955-0484; E-mail: gsemenza@gwgate1.jhmi.jhu.edu.

Received 6/13/97. Accepted 10/ 3/97.




This article has been cited by other articles:


Home page
Cancer Epidemiol. Biomarkers Prev.Home page
R. C.M. van Kruijsdijk, E. van der Wall, and F. L.J. Visseren
Obesity and Cancer: The Role of Dysfunctional Adipose Tissue
Cancer Epidemiol. Biomarkers Prev., October 1, 2009; 18(10): 2569 - 2578.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
L. Dalton-Griffin, S. J. Wilson, and P. Kellam
X-Box Binding Protein 1 Contributes to Induction of the Kaposi's Sarcoma-Associated Herpesvirus Lytic Cycle under Hypoxic Conditions
J. Virol., July 15, 2009; 83(14): 7202 - 7209.
[Abstract] [Full Text] [PDF]


Home page
J. Thorac. Cardiovasc. Surg.Home page
M. Wang, J. Tan, A. Coffey, J. Fehrenbacher, B. R. Weil, and D. R. Meldrum
Signal transducer and activator of transcription 3-stimulated hypoxia inducible factor-1{alpha} mediates estrogen receptor-{alpha}-induced mesenchymal stem cell vascular endothelial growth factor production
J. Thorac. Cardiovasc. Surg., July 1, 2009; 138(1): 163 - 171.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
J. Zhang, M. Sattler, G. Tonon, C. Grabher, S. Lababidi, A. Zimmerhackl, M. S. Raab, S. Vallet, Y. Zhou, M.-A. Cartron, et al.
Targeting Angiogenesis via a c-Myc/Hypoxia-Inducible Factor-1{alpha}-Dependent Pathway in Multiple Myeloma
Cancer Res., June 15, 2009; 69(12): 5082 - 5090.
[Abstract] [Full Text] [PDF]


Home page
CarcinogenesisHome page
R. Wirthner, S. Wrann, K. Balamurugan, R. H. Wenger, and D. P. Stiehl
Impaired DNA double-strand break repair contributes to chemoresistance in HIF-1{alpha}-deficient mouse embryonic fibroblasts
Carcinogenesis, December 1, 2008; 29(12): 2306 - 2316.
[Abstract] [Full Text] [PDF]


Home page
CarcinogenesisHome page
Z.-B. Han, H. Ren, H. Zhao, Y. Chi, K. Chen, B. Zhou, Y.-j. Liu, L. Zhang, B. Xu, B. Liu, et al.
Hypoxia-inducible factor (HIF)-1{alpha} directly enhances the transcriptional activity of stem cell factor (SCF) in response to hypoxia and epidermal growth factor (EGF)
Carcinogenesis, October 1, 2008; 29(10): 1853 - 1861.
[Abstract] [Full Text] [PDF]


Home page
Mol Cancer ResHome page
G. Niu, J. Briggs, J. Deng, Y. Ma, H. Lee, M. Kortylewski, M. Kujawski, H. Kay, W. D. Cress, R. Jove, et al.
Signal Transducer and Activator of Transcription 3 Is Required for Hypoxia-Inducible Factor-1{alpha} RNA Expression in Both Tumor Cells and Tumor-Associated Myeloid Cells
Mol. Cancer Res., July 1, 2008; 6(7): 1099 - 1105.
[Abstract] [Full Text] [PDF]


Home page
Molecular Cancer TherapeuticsHome page
X. Li, Y. Lu, K. Liang, T. Pan, J. Mendelsohn, and Z. Fan
Requirement of hypoxia-inducible factor-1{alpha} down-regulation in mediating the antitumor activity of the anti-epidermal growth factor receptor monoclonal antibody cetuximab
Mol. Cancer Ther., May 1, 2008; 7(5): 1207 - 1217.
[Abstract] [Full Text] [PDF]


Home page
GENES CELLSHome page
N. Shimada, T. Shinagawa, and S. Ishii
Modulation of M2-type pyruvate kinase activity by the cytoplasmic PML tumor suppressor protein.
Genes Cells, March 1, 2008; 13(3): 245 - 254.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
F.-P. Liang, C.-H. Lin, C.-D. Kuo, H.-P. Chao, and S.-L. Fu
Suppression of v-Src Transformation by Andrographolide via Degradation of the v-Src Protein and Attenuation of the Erk Signaling Pathway
J. Biol. Chem., February 22, 2008; 283(8): 5023 - 5033.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
C. Xia, Q. Meng, L.-Z. Liu, Y. Rojanasakul, X.-R. Wang, and B.-H. Jiang
Reactive Oxygen Species Regulate Angiogenesis and Tumor Growth through Vascular Endothelial Growth Factor
Cancer Res., November 15, 2007; 67(22): 10823 - 10830.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Pathol.Home page
S. Kalakonda, S. C. Nallar, P. Gong, D. J. Lindner, S. E. Goldblum, S. P. Reddy, and D. V. Kalvakolanu
Tumor Suppressive Protein Gene Associated with Retinoid-Interferon-Induced Mortality (GRIM)-19 Inhibits src-Induced Oncogenic Transformation at Multiple Levels
Am. J. Pathol., October 1, 2007; 171(4): 1352 - 1368.
[Abstract] [Full Text] [PDF]


Home page
Cancer Epidemiol. Biomarkers Prev.Home page
A. M. Niemela, P. Hynninen, J.-P. Mecklin, T. Kuopio, A. Kokko, L. Aaltonen, A.-K. Parkkila, S. Pastorekova, J. Pastorek, A. Waheed, et al.
Carbonic Anhydrase IX Is Highly Expressed in Hereditary Nonpolyposis Colorectal Cancer
Cancer Epidemiol. Biomarkers Prev., September 1, 2007; 16(9): 1760 - 1766.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
Q. Zhang, X. Tang, Z.-F. Zhang, R. Velikina, S. Shi, and A. D. Le
Nicotine Induces Hypoxia-Inducible Factor-1{alpha} Expression in Human Lung Cancer Cells via Nicotinic Acetylcholine Receptor Mediated Signaling Pathways
Clin. Cancer Res., August 15, 2007; 13(16): 4686 - 4694.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
L.-Z. Liu, X.-D. Zhou, G. Qian, X. Shi, J. Fang, and B.-H. Jiang
AKT1 Amplification Regulates Cisplatin Resistance in Human Lung Cancer Cells through the Mammalian Target of Rapamycin/p70S6K1 Pathway
Cancer Res., July 1, 2007; 67(13): 6325 - 6332.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
X. Tang, Q. Zhang, J. Nishitani, J. Brown, S. Shi, and A. D. Le
Overexpression of Human Papillomavirus Type 16 Oncoproteins Enhances Hypoxia-Inducible Factor 1{alpha} Protein Accumulation and Vascular Endothelial Growth Factor Expression in Human Cervical Carcinoma Cells
Clin. Cancer Res., May 1, 2007; 13(9): 2568 - 2576.
[Abstract] [Full Text] [PDF]


Home page
Genes Dev.Home page
J. J. Lum, T. Bui, M. Gruber, J. D. Gordan, R. J. DeBerardinis, K. L. Covello, M. C. Simon, and C. B. Thompson
The transcription factor HIF-1{alpha} plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis
Genes & Dev., May 1, 2007; 21(9): 1037 - 1049.
[Abstract] [Full Text] [PDF]


Home page
StrokeHome page
T. D. Ardizzone, X. Zhan, B. P. Ander, and F. R. Sharp
Src Kinase Inhibition Improves Acute Outcomes After Experimental Intracerebral Hemorrhage
Stroke, May 1, 2007; 38(5): 1621 - 1625.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
K. Fischer, P. Hoffmann, S. Voelkl, N. Meidenbauer, J. Ammer, M. Edinger, E. Gottfried, S. Schwarz, G. Rothe, S. Hoves, et al.
Inhibitory effect of tumor cell-derived lactic acid on human T cells
Blood, May 1, 2007; 109(9): 3812 - 3819.
[Abstract] [Full Text] [PDF]


Home page
CarcinogenesisHome page
Q. Zhou, L.-Z. Liu, B. Fu, X. Hu, X. Shi, J. Fang, and B.-H. Jiang
Reactive oxygen species regulate insulin-induced VEGF and HIF-1{alpha} expression through the activation of p70S6K1 in human prostate cancer cells
Carcinogenesis, January 1, 2007; 28(1): 28 - 37.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
H. Tanaka, M. Yamamoto, N. Hashimoto, M. Miyakoshi, S. Tamakawa, M. Yoshie, Y. Tokusashi, K. Yokoyama, Y. Yaginuma, and K. Ogawa
Hypoxia-Independent Overexpression of Hypoxia-Inducible Factor 1{alpha} as an Early Change in Mouse Hepatocarcinogenesis
Cancer Res., December 1, 2006; 66(23): 11263 - 11270.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
P. A. Carroll, H. L. Kenerson, R. S. Yeung, and M. Lagunoff
Latent Kaposi's Sarcoma-Associated Herpesvirus Infection of Endothelial Cells Activates Hypoxia-Induced Factors
J. Virol., November 1, 2006; 80(21): 10802 - 10812.
[Abstract] [Full Text] [PDF]


Home page
Mol. Pharmacol.Home page
Q. Ke and M. Costa
Hypoxia-Inducible Factor-1 (HIF-1)
Mol. Pharmacol., November 1, 2006; 70(5): 1469 - 1480.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
G.-C. Chang, K.-J. Liu, C.-L. Hsieh, T.-S. Hu, S. Charoenfuprasert, H.-K. Liu, K.-T. Luh, L.-H. Hsu, C.-W. Wu, C.-C. Ting, et al.
Identification of {alpha}-Enolase as an Autoantigen in Lung Cancer: Its Overexpression Is Associated with Clinical Outcomes.
Clin. Cancer Res., October 1, 2006; 12(19): 5746 - 5754.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
D. T. Jones, C. W. Pugh, S. Wigfield, M. F.G. Stevens, and A. L. Harris
Novel Thioredoxin Inhibitors Paradoxically Increase Hypoxia-Inducible Factor-{alpha} Expression but Decrease Functional Transcriptional Activity, DNA Binding, and Degradation.
Clin. Cancer Res., September 15, 2006; 12(18): 5384 - 5394.
[Abstract] [Full Text] [PDF]


Home page
Endocr Relat CancerHome page
K S Kimbro and J W Simons
Hypoxia-inducible factor-1 in human breast and prostate cancer.
Endocr. Relat. Cancer, September 1, 2006; 13(3): 739 - 749.
[Abstract] [Full Text] [PDF]


Home page
Molecular Cancer TherapeuticsHome page
D. T. Jones and A. L. Harris
Identification of novel small-molecule inhibitors of hypoxia-inducible factor-1 transactivation and DNA binding.
Mol. Cancer Ther., September 1, 2006; 5(9): 2193 - 2202.
[Abstract] [Full Text] [PDF]


Home page
Molecular Cancer TherapeuticsHome page
Q. Zhang, X. Tang, Q. Lu, Z. Zhang, J. Rao, and A. D. Le
Green tea extract and (-)-epigallocatechin-3-gallate inhibit hypoxia- and serum-induced HIF-1{alpha} protein accumulation and VEGF expression in human cervical carcinoma and hepatoma cells
Mol. Cancer Ther., May 1, 2006; 5(5): 1227 - 1238.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
J. Ding, J. Li, J. Chen, H. Chen, W. Ouyang, R. Zhang, C. Xue, D. Zhang, S. Amin, D. Desai, et al.
Effects of Polycyclic Aromatic Hydrocarbons (PAHs) on Vascular Endothelial Growth Factor Induction through Phosphatidylinositol 3-Kinase/AP-1-dependent, HIF-1{alpha}-independent Pathway
J. Biol. Chem., April 7, 2006; 281(14): 9093 - 9100.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
E. Gottfried, L. A. Kunz-Schughart, S. Ebner, W. Mueller-Klieser, S. Hoves, R. Andreesen, A. Mackensen, and M. Kreutz
Tumor-derived lactic acid modulates dendritic cell activation and antigen expression
Blood, March 1, 2006; 107(5): 2013 - 2021.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
C. E. Griguer, C. R. Oliva, E. E. Kelley, G. I. Giles, J. R. Lancaster Jr., and G. Y. Gillespie
Xanthine Oxidase-Dependent Regulation of Hypoxia-Inducible Factor in Cancer Cells
Cancer Res., February 15, 2006; 66(4): 2257 - 2263.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
A. Zetser, Y. Bashenko, E. Edovitsky, F. Levy-Adam, I. Vlodavsky, and N. Ilan
Heparanase Induces Vascular Endothelial Growth Factor Expression: Correlation with p38 Phosphorylation Levels and Src Activation
Cancer Res., February 1, 2006; 66(3): 1455 - 1463.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
D. T. Dang, F. Chen, L. B. Gardner, J. M. Cummins, C. Rago, F. Bunz, S. V. Kantsevoy, and L. H. Dang
Hypoxia-Inducible Factor-1{alpha} Promotes Nonhypoxia-Mediated Proliferation in Colon Cancer Cells and Xenografts
Cancer Res., February 1, 2006; 66(3): 1684 - 1693.
[Abstract] [Full Text] [PDF]


Home page
Mol. Pharmacol.Home page
L. M. Brown, R. L. Cowen, C. Debray, A. Eustace, J. T. Erler, F. C. D. Sheppard, C. A. Parker, I. J. Stratford, and K. J. Williams
Reversing Hypoxic Cell Chemoresistance in Vitro Using Genetic and Small Molecule Approaches Targeting Hypoxia Inducible Factor-1
Mol. Pharmacol., February 1, 2006; 69(2): 411 - 418.
[Abstract] [Full Text] [PDF]


Home page
Integr Cancer TherHome page
C. R. Pradeep, E. S. Sunila, and G. Kuttan
Expression of Vascular Endothelial Growth Factor (VEGF) and VEGF Receptors in Tumor Angiogenesis and Malignancies
Integr Cancer Ther, December 1, 2005; 4(4): 315 - 321.
[Abstract] [PDF]


Home page
EndocrinologyHome page
H. Y. Yeung, K. P. Lai, H. Y. Chan, N. K. Mak, G. F. Wagner, and C. K. C. Wong
Hypoxia-Inducible Factor-1-Mediated Activation of Stanniocalcin-1 in Human Cancer Cells
Endocrinology, November 1, 2005; 146(11): 4951 - 4960.
[Abstract] [Full Text] [PDF]


Home page
Mol. Pharmacol.Home page
L.-Z. Liu, J. Fang, Q. Zhou, X. Hu, X. Shi, and B.-H. Jiang
Apigenin Inhibits Expression of Vascular Endothelial Growth Factor and Angiogenesis in Human Lung Cancer Cells: Implication of Chemoprevention of Lung Cancer
Mol. Pharmacol., September 1, 2005; 68(3): 635 - 643.
[Abstract] [Full Text] [PDF]


Home page
Mol. Biol. CellHome page
D. Trisciuoglio, A. Iervolino, G. Zupi, and D. Del Bufalo
Involvement of PI3K and MAPK Signaling in bcl-2-induced Vascular Endothelial Growth Factor Expression in Melanoma Cells
Mol. Biol. Cell, September 1, 2005; 16(9): 4153 - 4162.
[Abstract] [Full Text] [PDF]


Home page
JCBHome page
R. Busca, E. Berra, C. Gaggioli, M. Khaled, K. Bille, B. Marchetti, R. Thyss, G. Fitsialos, L. Larribere, C. Bertolotto, et al.
Hypoxia-inducible factor 1{alpha} is a new target of microphthalmia-associated transcription factor (MITF) in melanoma cells
J. Cell Biol., July 4, 2005; 170(1): 49 - 59.
[Abstract] [Full Text] [PDF]


Home page
Neuro Oncol DukeHome page
E. W. Newcomb, M. A. Ali, T. Schnee, L. Lan, Y. Lukyanov, M. Fowkes, D. C. Miller, and D. Zagzag
Flavopiridol downregulates hypoxia-mediated hypoxia-inducible factor-1{alpha} expression in human glioma cells by a proteasome-independent pathway: Implications for in vivo therapy
Neuro-oncol, July 1, 2005; 7(3): 225 - 235.
[Abstract] [PDF]


Home page
Jpn J Clin OncolHome page
W.-T. Chen, C.-J. Huang, M.-T. Wu, S.-F. Yang, Y.-C. Su, and C.-Y. Chai
Hypoxia-inducible Factor-1{alpha} is Associated with Risk of Aggressive Behavior and Tumor Angiogenesis in Gastrointestinal Stromal Tumor
Jpn. J. Clin. Oncol., April 1, 2005; 35(4): 207 - 213.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
K. Hirota, R. Fukuda, S. Takabuchi, S. Kizaka-Kondoh, T. Adachi, K. Fukuda, and G. L. Semenza
Induction of Hypoxia-inducible Factor 1 Activity by Muscarinic Acetylcholine Receptor Signaling
J. Biol. Chem., October 1, 2004; 279(40): 41521 - 41528.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
H. Kato, S. Tamamizu-Kato, and F. Shibasaki
Histone Deacetylase 7 Associates with Hypoxia-inducible Factor 1{alpha} and Increases Transcriptional Activity
J. Biol. Chem., October 1, 2004; 279(40): 41966 - 41974.
[Abstract] [Full Text] [PDF]


Home page
J. Clin. Pathol.Home page
A E Greijer and E van der Wall
The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis
J. Clin. Pathol., October 1, 2004; 57(10): 1009 - 1014.
[Abstract] [Full Text] [PDF]


Home page
Mol. Pharmacol.Home page
J. Fang, Z. Cao, Y. C. Chen, E. Reed, and B.-H. Jiang
9-{beta}-D-Arabinofuranosyl-2-fluoroadenine Inhibits Expression of Vascular Endothelial Growth Factor through Hypoxia-Inducible Factor-1 in Human Ovarian Cancer Cells
Mol. Pharmacol., July 1, 2004; 66(1): 178 - 186.
[Abstract] [Full Text] [PDF]


Home page
J. Clin. Pathol.Home page
M R Morris, E Maina, N V Morgan, D Gentle, D Astuti, H Moch, T Kishida, M Yao, P Schraml, F M Richards, et al.
Molecular genetic analysis of FIH-1, FH, and SDHB candidate tumour suppressor genes in renal cell carcinoma
J. Clin. Pathol., July 1, 2004; 57(7): 706 - 711.
[Abstract] [Full Text] [PDF]


Home page
JNCI J Natl Cancer InstHome page
O. Stoeltzing, M. F. McCarty, J. S. Wey, F. Fan, W. Liu, A. Belcheva, C. D. Bucana, G. L. Semenza, and L. M. Ellis
Role of Hypoxia-Inducible Factor 1{alpha} in Gastric Cancer Cell Growth, Angiogenesis, and Vessel Maturation
J Natl Cancer Inst, June 16, 2004; 96(12): 946 - 956.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
N. Wakisaka, S. Kondo, T. Yoshizaki, S. Murono, M. Furukawa, and J. S. Pagano
Epstein-Barr Virus Latent Membrane Protein 1 Induces Synthesis of Hypoxia-Inducible Factor 1{alpha}
Mol. Cell. Biol., June 15, 2004; 24(12): 5223 - 5234.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
J. T. Erler, C. J. Cawthorne, K. J. Williams, M. Koritzinsky, B. G. Wouters, C. Wilson, C. Miller, C. Demonacos, I. J. Stratford, and C. Dive
Hypoxia-Mediated Down-Regulation of Bid and Bax in Tumors Occurs via Hypoxia-Inducible Factor 1-Dependent and -Independent Mechanisms and Contributes to Drug Resistance
Mol. Cell. Biol., April 1, 2004; 24(7): 2875 - 2889.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
G. Hopfl, O. Ogunshola, and M. Gassmann
HIFs and tumors--causes and consequences
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2004; 286(4): R608 - R623.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
C.-H. Chung, W.-B. Wu, and T.-F. Huang
Aggretin, a snake venom-derived endothelial integrin {alpha}2{beta}1 agonist, induces angiogenesis via expression of vascular endothelial growth factor
Blood, March 15, 2004; 103(6): 2105 - 2113.
[Abstract] [Full Text] [PDF]


Home page
Molecular Cancer TherapeuticsHome page
S. Welsh, R. Williams, L. Kirkpatrick, G. Paine-Murrieta, and G. Powis
Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1{alpha}
Mol. Cancer Ther., March 1, 2004; 3(3): 233 - 244.
[Abstract] [Full Text]


Home page
Clin. Cancer Res.Home page
G. E. Konecny, Y. G. Meng, M. Untch, H.-J. Wang, I. Bauerfeind, M. Epstein, P. Stieber, J.-M. Vernes, J. Gutierrez, K. Hong, et al.
Association between HER-2/neu and Vascular Endothelial Growth Factor Expression Predicts Clinical Outcome in Primary Breast Cancer Patients
Clin. Cancer Res., March 1, 2004; 10(5): 1706 - 1716.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
J. Li, G. Davidson, Y. Huang, B.-H. Jiang, X. Shi, M. Costa, and C. Huang
Nickel Compounds Act through Phosphatidylinositol-3-kinase/Akt-Dependent, p70S6k-Independent Pathway to Induce Hypoxia Inducible Factor Transactivation and Cap43 Expression in Mouse Epidermal Cl41 Cells
Cancer Res., January 1, 2004; 64(1): 94 - 101.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
N. El-Hashemite, V. Walker, H. Zhang, and D. J. Kwiatkowski
Loss of Tsc1 or Tsc2 Induces Vascular Endothelial Growth Factor Production through Mammalian Target of Rapamycin
Cancer Res., September 1, 2003; 63(17): 5173 - 5177.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
L. Zhang, N. Yang, D. Katsaros, W. Huang, J.-W. Park, S. Fracchioli, C. Vezzani, I. A. Rigault de la Longrais, W. Yao, S. C. Rubin, et al.
The Oncogene Phosphatidylinositol 3'-Kinase Catalytic Subunit {alpha} Promotes Angiogenesis via Vascular Endothelial Growth Factor in Ovarian Carcinoma
Cancer Res., July 15, 2003; 63(14): 4225 - 4231.
[Abstract] [Full Text] [PDF]


Home page
Hum Mol GenetHome page
R. D. Hawkins, S. Bashiardes, C. A. Helms, L. Hu, N. L. Saccone, M. E. Warchol, and M. Lovett
Gene expression differences in quiescent versus regenerating hair cells of avian sensory epithelia: implications for human hearing and balance disorders
Hum. Mol. Genet., June 1, 2003; 12(11): 1261 - 1272.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
L. E. Huang and H. F. Bunn
Hypoxia-inducible Factor and Its Biomedical Relevance
J. Biol. Chem., May 23, 2003; 278(22): 19575 - 19578.
[Full Text] [PDF]


Home page
Cancer Res.Home page
R. Fukuda, B. Kelly, and G. L. Semenza
Vascular Endothelial Growth Factor Gene Expression in Colon Cancer Cells Exposed to Prostaglandin E2 Is Mediated by Hypoxia-inducible Factor 1
Cancer Res., May 1, 2003; 63(9): 2330 - 2334.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
B. Krishnamachary, S. Berg-Dixon, B. Kelly, F. Agani, D. Feldser, G. Ferreira, N. Iyer, J. LaRusch, B. Pak, P. Taghavi, et al.
Regulation of Colon Carcinoma Cell Invasion by Hypoxia-Inducible Factor 1
Cancer Res., March 1, 2003; 63(5): 1138 - 1143.
[Abstract] [Full Text] [PDF]


Home page
Molecular Cancer TherapeuticsHome page
S. J. Welsh, R. R. Williams, A. Birmingham, D. J. Newman, D. L. Kirkpatrick, and G. Powis
The Thioredoxin Redox Inhibitors 1-Methylpropyl 2-Imidazolyl Disulfide and Pleurotin Inhibit Hypoxia-induced Factor 1{alpha} and Vascular Endothelial Growth Factor Formation
Mol. Cancer Ther., March 1, 2003; 2(3): 235 - 243.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
M. C. A. Duyndam, S. T. M. Hulscher, E. van der Wall, H. M. Pinedo, and E. Boven
Evidence for a Role of p38 Kinase in Hypoxia-inducible Factor 1-independent Induction of Vascular Endothelial Growth Factor Expression by Sodium Arsenite
J. Biol. Chem., February 21, 2003; 278(9): 6885 - 6895.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
N. Gao, B.-H. Jiang, S. S. Leonard, L. Corum, Z. Zhang, J. R. Roberts, J. Antonini, J. Z. Zheng, D. C. Flynn, V. Castranova, et al.
p38 Signaling-mediated Hypoxia-inducible Factor 1alpha and Vascular Endothelial Growth Factor Induction by Cr(VI) in DU145 Human Prostate Carcinoma Cells
J. Biol. Chem., November 15, 2002; 277(47): 45041 - 45048.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
M. Mayerhofer, P. Valent, W. R. Sperr, J. D. Griffin, and C. Sillaber
BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1alpha , through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin
Blood, November 15, 2002; 100(10): 3767 - 3775.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
R. Karni, Y. Dor, E. Keshet, O. Meyuhas, and A. Levitzki
Activated pp60c-Src Leads to Elevated Hypoxia-inducible Factor (HIF)-1alpha Expression under Normoxia
J. Biol. Chem., November 1, 2002; 277(45): 42919 - 42925.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
D. A. Chan, P. D. Sutphin, N. C. Denko, and A. J. Giaccia
Role of Prolyl Hydroxylation in Oncogenically Stabilized Hypoxia-inducible Factor-1alpha
J. Biol. Chem., October 11, 2002; 277(42): 40112 - 40117.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
S. J. Welsh, W. T. Bellamy, M. M. Briehl, and G. Powis
The Redox Protein Thioredoxin-1 (Trx-1) Increases Hypoxia-inducible Factor 1{alpha} Protein Expression: Trx-1 Overexpression Results in Increased Vascular Endothelial Growth Factor Production and Enhanced Tumor Angiogenesis
Cancer Res., September 1, 2002; 62(17): 5089 - 5095.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
N. Gao, M. Ding, J. Z. Zheng, Z. Zhang, S. S. Leonard, K. J. Liu, X. Shi, and B.-H. Jiang
Vanadate-induced Expression of Hypoxia-inducible Factor 1alpha and Vascular Endothelial Growth Factor through Phosphatidylinositol 3-Kinase/Akt Pathway and Reactive Oxygen Species
J. Biol. Chem., August 23, 2002; 277(35): 31963 - 31971.
[Abstract] [Full Text] [PDF]


Home page
Circ. Res.Home page
F. Jung, J. Haendeler, J. Hoffmann, A. Reissner, E. Dernbach, A. M. Zeiher, and S. Dimmeler
Hypoxic Induction of the Hypoxia-Inducible Factor Is Mediated via the Adaptor Protein Shc in Endothelial Cells
Circ. Res., July 12, 2002; 91(1): 38 - 45.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Heart Circ. Physiol.Home page
J. L. Tuttle, T. L. Hahn, B. M. Sanders, F. A. Witzmann, S. J. Miller, M. C. Dalsing, and J. L. Unthank
Impaired collateral development in mature rats
Am J Physiol Heart Circ Physiol, July 1, 2002; 283(1): H146 - H155.
[Abstract] [Full Text] [PDF]


Home page
Cardiovasc ResHome page
K.-G. Shyu, M.-T. Wang, B.-W. Wang, C.-C. Chang, J.-G. Leu, P. Kuan, and H. Chang
Intramyocardial injection of naked DNA encoding HIF-1{alpha}/VP16 hybrid to enhance angiogenesis in an acute myocardial infarction model in the rat
Cardiovasc Res, June 1, 2002; 54(3): 576 - 583.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
G. Hopfl, R. H. Wenger, U. Ziegler, T. Stallmach, O. Gardelle, R. Achermann, M. Wergin, B. Kaser-Hotz, H. M. Saunders, K. J. Williams, et al.
Rescue of Hypoxia-inducible Factor-1{alpha}-deficient Tumor Growth by Wild-Type Cells Is Independent of Vascular Endothelial Growth Factor
Cancer Res., May 1, 2002; 62(10): 2962 - 2970.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
L. Xu, D. Fukumura, and R. K. Jain
Acidic Extracellular pH Induces Vascular Endothelial Growth Factor (VEGF) in Human Glioblastoma Cells via ERK1/2 MAPK Signaling Pathway. MECHANISM OF LOW pH-INDUCED VEGF
J. Biol. Chem., March 22, 2002; 277(13): 11368 - 11374.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
J. R. Griffiths, P. M. J. McSheehy, S. P. Robinson, H. Troy, Y.-L. Chung, R. D. Leek, K. J. Williams, I. J. Stratford, A. L. Harris, and M. Stubbs
Metabolic Changes Detected by in Vivo Magnetic Resonance Studies of HEPA-1 Wild-Type Tumors and Tumors Deficient in Hypoxia-inducible Factor-1{beta} (HIF-1{beta}): Evidence of an Anabolic Role for the HIF-1 Pathway
Cancer Res., February 1, 2002; 62(3): 688 - 695.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
A. Alfranca, M. D. Gutierrez, A. Vara, J. Aragones, F. Vidal, and M. O. Landazuri
c-Jun and Hypoxia-Inducible Factor 1 Functionally Cooperate in Hypoxia-Induced Gene Transcription
Mol. Cell. Biol., January 1, 2002; 22(1): 12 - 22.
[Abstract] [Full Text] [PDF]


Home page
FASEB J.Home page
D. M. STROKA, T. BURKHARDT, I. DESBAILLETS, R. H. WENGER, D. A. H. NEIL, C. BAUER, M. GASSMANN, and D. CANDINAS
HIF-1 is expressed in normoxic tissue and displays an organ-specific regulation under systemic hypoxia
FASEB J, November 1, 2001; 15(13): 2445 - 2453.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
C. Blancher, J. W. Moore, N. Robertson, and A. L. Harris
Effects of ras and von Hippel-Lindau (VHL) Gene Mutations on Hypoxia-inducible Factor (HIF)-1{alpha}, HIF-2{alpha}, and Vascular Endothelial Growth Factor Expression and Their Regulation by the Phosphatidylinositol 3'-Kinase/Akt Signaling Pathway
Cancer Res., October 1, 2001; 61(19): 7349 - 7355.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
V. Vukovic, H. K. Haugland, T. Nicklee, A. J. Morrison, and D. W. Hedley
Hypoxia-inducible Factor-1{alpha} Is an Intrinsic Marker for Hypoxia in Cervical Cancer Xenografts
Cancer Res., October 1, 2001; 61(20): 7394 - 7398.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
A. Orimo, Y. Tomioka, Y. Shimizu, M. Sato, S. Oigawa, K. Kamata, Y. Nogi, S. Inoue, M. Takahashi, T. Hata, et al.
Cancer-associated Myofibroblasts Possess Various Factors to Promote Endometrial Tumor Progression
Clin. Cancer Res., October 1, 2001; 7(10): 3097 - 3105.
[Abstract] [Full Text] [PDF]


Home page
Cell Growth Differ.Home page
B.-H. Jiang, G. Jiang, J. Z. Zheng, Z. Lu, T. Hunter, and P. K. Vogt
Phosphatidylinositol 3-Kinase Signaling Controls Levels of Hypoxia-inducible Factor 1
Cell Growth Differ., July 1, 2001; 12(7): 363 - 369.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
M. S. Wiesener, P. M. Munchenhagen, I. Berger, N. V. Morgan, J. Roigas, A. Schwiertz, J. S. Jurgensen, G. Gruber, P. H. Maxwell, S. A. Loning, et al.
Constitutive Activation of Hypoxia-inducible Genes Related to Overexpression of Hypoxia-inducible Factor-1{{alpha}} in Clear Cell Renal Carcinomas
Cancer Res., July 1, 2001; 61(13): 5215 - 5222.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
E. Laughner, P. Taghavi, K. Chiles, P. C. Mahon, and G. L. Semenza
HER2 (neu) Signaling Increases the Rate of Hypoxia-Inducible Factor 1{alpha} (HIF-1{alpha}) Synthesis: Novel Mechanism for HIF-1-Mediated Vascular Endothelial Growth Factor Expression
Mol. Cell. Biol., June 15, 2001; 21(12): 3995 - 4004.
[Abstract] [Full Text]


Home page
Cancer Res.Home page
Q. Shi, X. Le, J. L. Abbruzzese, Z. Peng, C.-N. Qian, H. Tang, Q. Xiong, B. Wang, X.-C. Li, and K. Xie
Constitutive Sp1 Activity Is Essential for Differential Constitutive Expression of Vascular Endothelial Growth Factor in Human Pancreatic Adenocarcinoma
Cancer Res., May 1, 2001; 61(10): 4143 - 4154.
[Abstract] [Full Text]


Home page
Clin. Cancer Res.Home page
A. Jones, C. Fujiyama, C. Blanche, J. W. Moore, S. Fuggle, D. Cranston, R. Bicknell, and Adrian. L. Harris
Relation of Vascular Endothelial Growth Factor Production to Expression and Regulation of Hypoxia-inducible Factor-1{{alpha}} and Hypoxia-inducible Factor-2{{alpha}} in Human Bladder Tumors and Cell Lines
Clin. Cancer Res., May 1, 2001; 7(5): 1263 - 1272.
[Abstract] [Full Text]


Home page
Mol. Pharmacol.Home page
E. Hur, K. Y. Chang, E. Lee, S.-K. Lee, and H. Park
Mitogen-Activated Protein Kinase Kinase Inhibitor PD98059 Blocks the trans-Activation but Not the Stabilization or DNA Binding Ability of Hypoxia-Inducible Factor-1alpha
Mol. Pharmacol., April 16, 2001; 59(5): 1216 - 1224.
[Abstract] [Full Text]


Home page
Cancer Res.Home page
D. M. Aebersold, P. Burri, K. T. Beer, J. Laissue, V. Djonov, R. H. Greiner, and G. L. Semenza
Expression of Hypoxia-inducible Factor-1{{alpha}}: A Novel Predictive and Prognostic Parameter in the Radiotherapy of Oropharyngeal Cancer
Cancer Res., April 1, 2001; 61(7): 2911 - 2916.
[Abstract] [Full Text]


Home page
Cancer Res.Home page
E. Y. Chen, N. M. Mazure, J. A. Cooper, and A. J. Giaccia
Hypoxia Activates a Platelet-derived Growth Factor Receptor/Phosphatidylinositol 3-Kinase/Akt Pathway That Results in Glycogen Synthase Kinase-3 Inactivation
Cancer Res., March 1, 2001; 61(6): 2429 - 2433.
[Abstract] [Full Text]


Home page
JNCI J Natl Cancer InstHome page
R. Bos, H. Zhong, C. F. Hanrahan, E. C. M. Mommers, G. L. Semenza, H. M. Pinedo, M. D. Abeloff, J. W. Simons, P. J. van Diest, and E. van der Wall
Levels of Hypoxia-Inducible Factor-1{{alpha}} During Breast Carcinogenesis
J Natl Cancer Inst, February 21, 2001; 93(4): 309 - 314.
[Abstract] [Full Text] [PDF]


Home page
Biol. Reprod.Home page
A. Rajakumar, K. A. Whitelock, L. A. Weissfeld, A. R. Daftary, N. Markovic, and K. P. Conrad
Selective Overexpression of the Hypoxia-Inducible Transcription Factor, HIF-2{{alpha}}, in Placentas from Women with Preeclampsia
Biol Reprod, February 1, 2001; 64(2): 499 - 506.
[Abstract] [Full Text]


Home page
Cancer Res.Home page
C. C. Wykoff, N. J. P. Beasley, P. H. Watson, K. J. Turner, J. Pastorek, A. Sibtain, G. D. Wilson, H. Turley, K. L. Talks, P. H. Maxwell, et al.
Hypoxia-inducible Expression of Tumor-associated Carbonic Anhydrases
Cancer Res., December 1, 2000; 60(24): 7075 - 7083.
[Abstract] [Full Text]


Home page
Cancer Res.Home page
C. Blancher, J. W. Moore, K. L. Talks, S. Houlbrook, and A. L. Harris
Relationship of Hypoxia-inducible Factor (HIF)-1{{alpha}} and HIF-2{{alpha}} Expression to Vascular Endothelial Growth Factor Induction and Hypoxia Survival in Human Breast Cancer Cell Lines
Cancer Res., December 1, 2000; 60(24): 7106 - 7113.
[Abstract] [Full Text]


Home page
Cancer Res.Home page
D. A. Elson, H. E. Ryan, J. W. Snow, R. Johnson, and J. M. Arbeit
Coordinate Up-Regulation of Hypoxia Inducible Factor (HIF)-1{{alpha}} and HIF-1 Target Genes during Multi-Stage Epidermal Carcinogenesis and Wound Healing
Cancer Res., November 1, 2000; 60(21): 6189 - 6195.
[Abstract] [Full Text]


Home page
Cancer Res.Home page
A. Sodhi, S. Montaner, V. Patel, M. Zohar, C. Bais, E. A. Mesri, and J. S. Gutkind
The Kaposi's Sarcoma-associated Herpes Virus G Protein-coupled Receptor Up-Regulates Vascular Endothelial Growth Factor Expression and Secretion through Mitogen-activated Protein Kinase and p38 Pathways Acting on Hypoxia-inducible Factor 1{{alpha}}
Cancer Res., September 1, 2000; 60(17): 4873 - 4880.
[Abstract] [Full Text]


Home page
Genes Dev.Home page
G. L. Semenza
HIF-1 and human disease: one highly involved factor
Genes & Dev., August 15, 2000; 14(16): 1983 - 1991.
[Full Text]


Home page
Am. J. Pathol.Home page
K. L. Talks, H. Turley, K. C. Gatter, P. H. Maxwell, C. W. Pugh, P. J. Ratcliffe, and A. L. Harris
The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1{alpha} and HIF-2{alpha} in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages
Am. J. Pathol., August 1, 2000; 157(2): 411 - 421.
[Abstract] [Full Text] [PDF]


Home page
Biol. Reprod.Home page
A. Rajakumar and K. P. Conrad
Expression, Ontogeny, and Regulation of Hypoxia-Inducible Transcription Factors in the Human Placenta
Biol Reprod, August 1, 2000; 63(2): 559 - 569.
[Abstract] [Full Text]


Home page
Cancer Res.Home page
L. Zhang, D. Yu, M. Hu, S. Xiong, A. Lang, L. M. Ellis, and R. E. Pollock
Wild-Type p53 Suppresses Angiogenesis in Human Leiomyosarcoma and Synovial Sarcoma by Transcriptional Suppression of Vascular Endothelial Growth Factor Expression
Cancer Res., July 1, 2000; 60(13): 3655 - 3661.
[Abstract] [Full Text]


Home page
Clin. Cancer Res.Home page
K. R. Laderoute, R. M. Alarcon, M. D. Brody, J. M. Calaoagan, E. Y. Chen, A. M. Knapp, Z. Yun, N. C. Denko, and A. J. Giaccia
Opposing Effects of Hypoxia on Expression of the Angiogenic Inhibitor Thrombospondin 1 and the Angiogenic Inducer Vascular Endothelial Growth Factor
Clin. Cancer Res., July 1, 2000; 6(7): 2941 - 2950.
[Abstract] [Full Text]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 1997 by the American Association for Cancer Research.