| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
ABL-Basic Research Program, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702
Using double immunofluorescence staining and quantitative confocal laser scan microscopy, we show that the intensity of hepatocyte growth factor/scatter factor (HGF/SF) and Met staining in human primary brain tumors increases with the grade of malignancy and is prevalent in both the infiltrating tumor cells and endothelial hyperplastic areas. HGF/SF and Met also are expressed in vitro in glioblastoma multiforme cell lines as well as in normal human astrocyte (NHA) cells. Moreover, HGF/SF stimulates tyrosine phosphorylation of Met in both glioma cell lines and NHA cells, but only the glioma cell lines proliferate and become motile and invasive in response to HGF/SF, whereas the NHA cells are nonresponsive. These results implicate autocrine/paracrine Met-HGF/SF signaling in glioma tumorigenesis and suggest that HGF/SF signaling through Met is negatively regulated in NHA cells.
1 Sponsored by the National Cancer Institute, Department of Health and Human Services, under contract with ABL.
2 To whom requests for reprints should be addressed, at ABL-Basic Research Program, National Cancer Institute, Frederick Cancer Research and Development Center, P. O. Box B, Frederick, MD 21702.
Received 7/14/97. Accepted 10/ 3/97.
This article has been cited by other articles:
|
|
 |
|
  Y. Li, F. Guessous, Y. Zhang, C. DiPierro, B. Kefas, E. Johnson, L. Marcinkiewicz, J. Jiang, Y. Yang, T. D. Schmittgen, et al. MicroRNA-34a Inhibits Glioblastoma Growth by Targeting Multiple Oncogenes Cancer Res., October 1, 2009; 69(19): 7569 - 7576. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Lou, Q. Zhou, Y. Yin, C. Zhou, and Y. Shen Inhibition of the met receptor tyrosine kinase signaling enhances the chemosensitivity of glioma cell lines to CDDP through activation of p38 MAPK pathway Mol. Cancer Ther., May 1, 2009; 8(5): 1126 - 1136. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Li, F. Guessous, C. DiPierro, Y. Zhang, T. Mudrick, L. Fuller, E. Johnson, L. Marcinkiewicz, M. Engelhardt, B. Kefas, et al. Interactions between PTEN and the c-Met pathway in glioblastoma and implications for therapy Mol. Cancer Ther., February 1, 2009; 8(2): 376 - 385. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Binning, T. Niazi, C. A. Pedone, B. Lal, C. G. Eberhart, K. J. Kim, J. Laterra, and D. W. Fults Hepatocyte Growth Factor and Sonic Hedgehog Expression in Cerebellar Neural Progenitor Cells Costimulate Medulloblastoma Initiation and Growth Cancer Res., October 1, 2008; 68(19): 7838 - 7845. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Choquette, L. Liu, T.-S. Kim, M. Norman, A. Siegmund, N. Xi, S. F Bellon, A. Chen, P. Kaplan-Lefko, M. Lee, et al. Discovery of AMG 458: A Potent, Selective, and Orally Bioavailable c-Met Inhibitor Am. Assoc. Cancer Res. Educ. Book, April 12, 2008; 2008(1): 713 - 718. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. T. Jun, J. Sun, K. Rex, R. Radinsky, R. Kendall, A. Coxon, and T. L. Burgess AMG 102, A Fully Human Anti-Hepatocyte Growth Factor/Scatter Factor Neutralizing Antibody, Enhances the Efficacy of Temozolomide or Docetaxel in U-87 MG Cells and Xenografts Clin. Cancer Res., November 15, 2007; 13(22): 6735 - 6742. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. B. Hoelzinger, T. Demuth, and M. E. Berens Autocrine Factors That Sustain Glioma Invasion and Paracrine Biology in the Brain Microenvironment J Natl Cancer Inst, November 7, 2007; 99(21): 1583 - 1593. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. H. Huang, A. Mukasa, R. Bonavia, R. A. Flynn, Z. E. Brewer, W. K. Cavenee, F. B. Furnari, and F. M. White Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma PNAS, July 31, 2007; 104(31): 12867 - 12872. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Gao, K. Furge, J. Koeman, K. Dykema, Y. Su, M. L. Cutler, A. Werts, P. Haak, and G. F. Vande Woude Chromosome instability, chromosome transcriptome, and clonal evolution of tumor cell populations PNAS, May 22, 2007; 104(21): 8995 - 9000. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Martens, N.-O. Schmidt, C. Eckerich, R. Fillbrandt, M. Merchant, R. Schwall, M. Westphal, and K. Lamszus A Novel One-Armed Anti-c-Met Antibody Inhibits Glioblastoma Growth In vivo. Clin. Cancer Res., October 15, 2006; 12(20): 6144 - 6152. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Athauda, A. Giubellino, J. A. Coleman, C. Horak, P. S. Steeg, M.-J. Lee, J. Trepel, J. Wimberly, J. Sun, A. Coxon, et al. c-Met Ectodomain Shedding Rate Correlates with Malignant Potential. Clin. Cancer Res., July 15, 2006; 12(14): 4154 - 4162. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Watanabe, M. Tsuda, Y. Makino, S. Ichihara, H. Sawa, A. Minami, N. Mochizuki, K. Nagashima, and S. Tanaka Adaptor Molecule Crk Is Required for Sustained Phosphorylation of Grb2-Associated Binder 1 and Hepatocyte Growth Factor-Induced Cell Motility of Human Synovial Sarcoma Cell Lines Mol. Cancer Res., July 1, 2006; 4(7): 499 - 510. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J. Kim, L. Wang, Y.-C. Su, G. Y. Gillespie, A. Salhotra, B. Lal, and J. Laterra Systemic Anti-Hepatocyte Growth Factor Monoclonal Antibody Therapy Induces the Regression of Intracranial Glioma Xenografts Clin. Cancer Res., February 15, 2006; 12(4): 1292 - 1298. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Burgess, A. Coxon, S. Meyer, J. Sun, K. Rex, T. Tsuruda, Q. Chen, S.-Y. Ho, L. Li, S. Kaufman, et al. Fully Human Monoclonal Antibodies to Hepatocyte Growth Factor with Therapeutic Potential against Hepatocyte Growth Factor/c-Met-Dependent Human Tumors Cancer Res., February 1, 2006; 66(3): 1721 - 1729. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Abounader and J. Laterra Scatter factor/hepatocyte growth factor in brain tumor growth and angiogenesis Neuro-oncol, October 1, 2005; 7(4): 436 - 451. [Abstract] [PDF]
|
|
|
|
|
|
C.-F. Gao, Q. Xie, Y.-L. Su, J. Koeman, S. K. Khoo, M. Gustafson, B. S. Knudsen, R. Hay, N. Shinomiya, and G. F. V. Woude Proliferation and invasion: Plasticity in tumor cells PNAS, July 26, 2005; 102(30): 10528 - 10533. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Lal, S. Xia, R. Abounader, and J. Laterra Targeting the c-Met Pathway Potentiates Glioblastoma Responses to {gamma}-Radiation Clin. Cancer Res., June 15, 2005; 11(12): 4479 - 4486. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Schag, S. M. Schmidt, M. R. Muller, T. Weinschenk, S. Appel, M. M. Weck, F. Grunebach, S. Stevanovic, H.-G. Rammensee, and P. Brossart Identification of C-Met Oncogene as a Broadly Expressed Tumor-Associated Antigen Recognized by Cytotoxic T-Lymphocytes Clin. Cancer Res., June 1, 2004; 10(11): 3658 - 3666. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Brockmann, A. Papadimitriou, M. Brandt, R. Fillbrandt, M. Westphal, and K. Lamszus Inhibition of Intracerebral Glioblastoma Growth by Local Treatment with the Scatter Factor/Hepatocyte Growth Factor-Antagonist NK4 Clin. Cancer Res., October 1, 2003; 9(12): 4578 - 4585. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Yu and G. Merlino Constitutive c-Met Signaling through a Nonautocrine Mechanism Promotes Metastasis in a Transgenic Transplantation Model Cancer Res., May 1, 2002; 62(10): 2951 - 2956. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Lamorte, I. Royal, M. Naujokas, and M. Park Crk Adapter Proteins Promote an Epithelial-Mesenchymal-like Transition and Are Required for HGF-mediated Cell Spreading and Breakdown of Epithelial Adherens Junctions Mol. Biol. Cell, May 1, 2002; 13(5): 1449 - 1461. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. Walter, M. A. Hossain, C. Luddy, N. Goel, T. E. Reznik, and J. Laterra Scatter Factor/Hepatocyte Growth Factor Stimulation of Glioblastoma Cell Cycle Progression through G1 Is c-Myc Dependent and Independent of p27 Suppression, Cdk2 Activation, or E2F1-Dependent Transcription Mol. Cell. Biol., April 15, 2002; 22(8): 2703 - 2715. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. C. Hu, K. Y. Lam, S. Law, J. Wong, and G. Srivastava Profiling of Differentially Expressed Cancer-related Genes in Esophageal Squamous Cell Carcinoma (ESCC) Using Human Cancer cDNA Arrays: Overexpression of Oncogene MET Correlates with Tumor Differentiation in ESCC Clin. Cancer Res., November 1, 2001; 7(11): 3519 - 3525. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. A. Gmyrek, M. Walburg, C. P. Webb, H.-M. Yu, X. You, E. D. Vaughan, G. F. Vande Woude, and B. S. Knudsen Normal and Malignant Prostate Epithelial Cells Differ in Their Response to Hepatocyte Growth Factor/Scatter Factor Am. J. Pathol., August 1, 2001; 159(2): 579 - 590. [Abstract] [Full Text]
|
|
|
|
|
|
B. Cao, Y. Su, M. Oskarsson, P. Zhao, E. J. Kort, R. J. Fisher, L.-M. Wang, and G. F. Vande Woude Neutralizing monoclonal antibodies to hepatocyte growth factor/scatter factor (HGF/SF) display antitumor activity in animal models PNAS, June 19, 2001; 98(13): 7443 - 7448. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Kunkel, S. Muller, P. Schirmacher, D. Stavrou, R. Fillbrandt, M. Westphal, and K. Lamszus Expression and localization of scatter factor/hepatocyte growth factor in human astrocytomas Neuro-oncol, April 1, 2001; 3(2): 82 - 88. [Abstract] [PDF]
|
|
|
|
|
|
D. C. Bowers, S. Fan, K. A. Walter, R. Abounader, J. A. Williams, E. M. Rosen, and J. Laterra Scatter Factor/Hepatocyte Growth Factor Protects against Cytotoxic Death in Human Glioblastoma via Phosphatidylinositol 3-Kinase- and AKT-dependent Pathways Cancer Res., August 1, 2000; 60(15): 4277 - 4283. [Abstract] [Full Text]
|
|
|
|
|
|
K. Lashkari, T. Hirose, J. Yazdany, J. W. McMeel, A. Kazlauskas, and N. Rahimi Vascular Endothelial Growth Factor and Hepatocyte Growth Factor Levels Are Differentially Elevated in Patients with Advanced Retinopathy of Prematurity Am. J. Pathol., April 1, 2000; 156(4): 1337 - 1344. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. A. Taylor, E. Hudson, J. H. Resau, and G. F. Vande Woude Regulation of P311 Expression by Met-Hepatocyte Growth Factor/Scatter Factor and the Ubiquitin/Proteasome System J. Biol. Chem., February 11, 2000; 275(6): 4215 - 4219. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Reis, D. Konu-Lebleblicioglu, J. M. Lopes, P. Kleihues, and H. Ohgaki Genetic Profile of Gliosarcomas Am. J. Pathol., February 1, 2000; 156(2): 425 - 432. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. P. Webb, C. D. Hose, S. Koochekpour, M. Jeffers, M. Oskarsson, E. Sausville, A. Monks, and G. F. Vande Woude The Geldanamycins Are Potent Inhibitors of the Hepatocyte Growth Factor/Scatter Factor-Met-Urokinase Plasminogen Activator-Plasmin Proteolytic Network Cancer Res., January 1, 2000; 60(2): 342 - 349. [Abstract] [Full Text]
|
|
|
|
|
|
S. Koochekpour, M. Jeffers, P. H. Wang, C. Gong, G. A. Taylor, L. M. Roessler, R. Stearman, J. R. Vasselli, W. G. Stetler-Stevenson, W. G. Kaelin Jr., et al. The von Hippel-Lindau Tumor Suppressor Gene Inhibits Hepatocyte Growth Factor/Scatter Factor-Induced Invasion and Branching Morphogenesis in Renal Carcinoma Cells Mol. Cell. Biol., September 1, 1999; 19(9): 5902 - 5912. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
